Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: Suppression of inducible nitric oxide synthase in arthritic rats

Physical Therapy

Volumn 86, Issue 1, 2006, Pages 39-49

  Hsieh, Yueh Ling ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Adjuvant induced inflammation; Diclofenac phonophoresis; Inducible nitric oxide synthase; Nociception; Spinal cord; Ultrasound

Indexed keywords

DICLOFENAC; FREUND ADJUVANT; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; EDEMA; ENZYME REPRESSION; HINDLIMB; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LUMBAR SPINAL CORD; MALE; NOCICEPTION; NONHUMAN; PAIN; RAT; REARING; ULTRASOUND;

EID: 29744453541     PISSN: 00319023     EISSN: None     Source Type: Journal    
DOI: 10.1093/ptj/86.1.39     Document Type: Article

References (66)

1. ter Haar G. Therapeutic ultrasound. Eur J Ultrasound. 1999;9:3-9.
2. Dyson M. Non-thermal cellular effects of ultrasound. Br J Cancer Suppl. 1982;45:165-171.
3. Dyson M. Mechanisms involved in therapeutic ultrasound. Physiotherapy. 1987;73:116-120.
4. Guffey JS, Knaust ML. The use and efficacy of ultrasound. Rehab Manag. 1997;10:44, 48-50, 115.
5. Currier DP, Greathouse D, Swift T. Sensory nerve conduction: effect of ultrasound. Arch Phys Med Rehabil. 1978;59:181-185.
6. Tyle P, Agrawala P. Drug delivery by phonophoresis. Pharm Res. 1989;6:355-361.
7. Wells PN. Ultrasonics in medicine and biology. Phys Med Biol. 1977;22:629-669.
8. Byl NN. The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. Phys Ther. 1995;75:539-553.
9. Gelgor L, Phillips S, Butkow N, Mitchell D. Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats. Pain. 1986;26:353-359.
10. Gelgor L, Butkow N, Mitchell D. Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats. Br J Pharmacol. 1992;105:412-416.
11. Gelgor L, Cartmell S, Mitchell D. Intracerebroventricular microinjections of non-steroidal anti-inflammatory drugs abolish reperfusion hyperalgesia in the rat's tail. Pain. 1992;50:323-329.
12. Gelgor L, Ford DM, Mitchell D. Behavioral and thalamic nociceptive responses in rats following noxious ischaemia of the tail. Pain. 1988;34:205-211.
13. Todd PA, Sorkin EM. Diclofenac sodium: a reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1988;35:244-285.
14. Snyder SH, Bredt DS. Biological roles of nitric oxide. Sci Am. 1992;266:68-71, 74-77.
15. Forstermann U, Kleinert H. Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch Pharmacol. 1995;352:351-364.
16. Maihöfner C, Euchenhofer C, Tegeder I, et al. Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation. Neurosci Lett. 2000;290:71-75.
17. Coleman JW. Nitric oxide in immunity and inflammation. Int Immunopharmacol. 2001;1:1397-1406.
18. Tedesco LS, Fuseler J, Grisham M, et al. Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. Pain. 2002;95:215-223.
19. Miyasaka N, Hirata Y. Nitric oxide and inflammatory arthritides. Life Sci. 1997;61:2073-2081.
20. Cannon GW, Openshaw SJ, Hibbs JB Jr, et al. Nitric oxide production during adjuvant-induced and collagen-induced arthritis. Arthritis Rheum. 1996;39:1677-1684.
21. Guhring H, Gorig M, Ates M, et al. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J Neurosci. 2000;20:6714-6720.
22. Guhring H, Tegeder I, Lotsch J, et al. Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia. Inflamm Res. 2001;50:83-88.
23. Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994;78:915-918.
24. Southan GJ, Szabo C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol. 1996;51:383-394.
25. Heales SJ, Bolanos JP, Stewart VC, et al. Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta. 1999;1410:215-228.
26. Willenborg DO, Fordham SA, Staykova MA, et al. IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol. 1999;163:5278-5286.
27. Attal N, Kayser V, Eschalier A, et al. Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, sodium diclofenac. Pain. 1988;35:341-348.
28. Schott E, Berge OG, Angeby-Moller K, et al. Weight bearing as an objective measure of arthritic pain in the rat. J Pharmacol Toxicol Methods. 1994;31:79-83.
29. Bendele A, McComb J, Gould T, et al. Animal models of arthritis: relevance to human disease. Toxicol Pathol. 1999;27:134-142.
30. Ialenti A, Moncada S, Di Rosa M. Modulation of adjuvant arthritis by endogenous nitric oxide. Br J Pharmacol. 1993;110:701-706.
31. Butler SH, Godefroy F, Besson JM, et al. A limited arthritic model for chronic pain studies in the rat. Pain. 1992;48:73-81.
32. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.
33. Hsieh YL, Chen SS, Huang CW. Peripheral ultrasound stimulation reorganized the distribution of spinal c-Fos immunoreactivity induced by early or late phase of inflammation. Abstract presented at: 50th Scientific Conference of the Physical Therapy Association of The Republic of China; March 20, 2005; Kaohsiung, Taiwan.
34. Hsieh YL, Chen TJ, Lin CH, Chen SS. Effect of olivocochlear bundle lesion on locomotor activity in rats. Physiol Behav. 1998;64:179-184.
35. Hsieh YL, Yang CC, Kuo HW. Comparison of temperature rise with ultrasound in rat calf muscles after the application of five non-steroidal anti-inflammatory drugs. Taiwan J Phys Med Rehabil. In press.
36. Asano J, Suisha F, Takada M, et al. Effect of pulsed output ultrasound on the transdermal absorption of indomethacin from an ointment in rats. Biol Pharm Bull. 1997;20:288-291.
37. Molander C, Xu Q, Grant G. The cytoarchitectonic organization of the spinal cord in the rat, I: the lower thoracic and lumbosacral cord. J Comp Neurol. 1984;30:133-141.
38. Woolf CJ. Recent advances in the pathophysiology of acute pain. Br J Anaesth. 1989;63:139-146.
39. Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res Bull. 1999;48:129-141.
40. Kamisaki Y, Nakamoto K, Wada K, Itoh T. Nitric oxide regulates substance P release from rat spinal cord synaptosomes. J Neurochem. 1995;65:2050-2056.
41. Rybarova S, Kluchova D, Lovasova K, et al. Expression of peptidergic and nitrergic structures in dorsal root ganglia of the rabbit. Eur J Histochem. 2000;44:377-384.
42. Moore PK, Oluyomi AO, Babbedge RC, et al. L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol. 1991;102:198-202.
43. Kuo PC, Abe KY. Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity. FEBS Lett. 1995;360:10-14.
44. Meller ST, Dykstra C, Grzybycki D, et al. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology. 1994;33:1471-1478.
45. Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 1993;54:291-300.
46. Heneka MT, Klockgether T, Feinstein DL. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J Neurosci. 2000;20:6862-6867.
47. Murrell GA, Doland MM, Jang D, et al. Nitric oxide: an important articular free radical. J Bone Joint Surg Am. 1996;78:265-274.
48. Mao J, Price DD, Coghill RC, et al. Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy. Pain. 1992;50:89-100.
49. Schadrack J, Neto FL, Ableitner A, et al. Metabolic activity changes in the rat spinal cord during adjuvant monoarthritis. Neuroscience. 1999;94:595-605.
50. Traub RJ, Solodkin A, Gebhart GF. NADPH-diaphorase histochemistry provides evidence for a bilateral, somatotopically inappropriate response to unilateral hindpaw inflammation in the rat. Brain Res. 1994;647:113-123.
51. Bredt DS, Glatt CE, Hwang PM, et al. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 1991;7:615-624.
52. Wu J, Lin Q, Lu Y, et al. Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis. Exp Brain Res. 1998;118:457-465.
53. Murphy S, Simmons ML, Agullo L, et al. Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 1993;16:323-328.
54. Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain. 2001;93:201-205.
55. Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol. 2003;521:1-21.
56. Hsieh YL. Reduction in induced pain by ultrasound may be caused by altered expression of spinal neuronal nitric oxide synthase-producing neurons. Arch Phys Med Rehabil. 2005;86:1311-1317.
57. Klaiman MD, Shrader JA, Danoff JV, et al. Phonophoresis versus ultrasound in the treatment of common musculoskeletal conditions. Med Sci Sports Exerc. 1998;30:1349-1355.
58. Kozanoglu E, Basaran S, Guzel R, Guler-Uysal F. Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis. Swiss Med Wkly. 2003;133:333-338.
59. Heneka MT, Feinstein DL. Expression and function of inducible nitric oxide synthase in neurons. J Neuroimmunol. 2001;114:8-18.
60. McCormack K. Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain. 1994;59:9-43.
61. Sanberg PR, Moran TH, Kubos KL, Coyle JT. Automated measurement of rearing behavior in adult and neonatal rats. Behav Neurosci. 1984;98:743-746.
62. Aloisi AM, Albonetti ME, Carli G. Behavioural effects of different intensities of formalin pain in rats. Physiol Behav. 1995;58:603-610.
63. Aloisi AM, Lupo C, Carli G. Effects of formalin-induced pain on exploratory behaviour in rabbits. Neuroreport. 1993;4:739-742.
64. Gam AN, Johannsen F. Ultrasound therapy in musculoskeletal disorders: a meta-analysis. Pain. 1995;63:85-91.
65. van der Windt DA, van der Heijden GJ, van den Berg SG, et al. Ultrasound therapy for musculoskeletal disorders: a systematic review. Pain. 1999;81:257-271.
66. Colpaert FC. Evidence that adjuvant arthritis in the rat is associated with chronic pain. Pain. 1987;28:201-222.