Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5277-5284

  Vasdev, Neil ^a,b   LaRonde, Frank J ^c   Woodgett, James R ^d,e   Garcia, Armando ^a   Rubie, Elizabeth A ^e   Meyer, Jeffrey H ^a,b   Houle, Sylvain ^a,b   Wilson, Alan A ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Laro Chemicals   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Carbon 11; H 89; H 9; PET; Protein kinase A; Signal transduction

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DIAMINE DERIVATIVE; ISOQUINOLINE 5 SULFONYL CHLORIDE; N (2 AMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N (2 AMINOETHYL) N METHYL ISOQUINOLINE 5 SULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL]N METHYL ISOQUINOLINE 5 SULFONAMIDE C 11; N [2 [BIS(4 BROMOCINNAMYL)AMINO]ETHYL] N METHYL ISOQUINOLINE 5 SULFONAMIDE; N METHYLETHYLENEDIAMINE; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; MALE; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOACTIVITY; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; BRAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TIME FACTORS; TISSUE DISTRIBUTION;

RATTUS;

EID: 43049097156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.013     Document Type: Article

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