Inhibitory effect of simvastatin on the TNF-α- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation

Archives of Pharmacal Research

Volumn 31, Issue 2, 2008, Pages 195-204

  Park, Su Young ^a   Lee, Jong Suk ^a   Ko, Yu Jin ^a   Kim, Ah Ra ^a   Choi, Mi Kyoung ^a   Kwak, Mi Kyoung ^a   Choi, Han Gon ^a   Yong, Chul Soon ^a   Kim, Jung Ae ^a  

^a Yeungnam University   (South Korea)

Author keywords

Angiotensin II; Mevalonate; Monocyte endothelial cell adhesion; Reactive oxygen species; Simvastatin; Tumor necrosis factor

Indexed keywords

ANGIOTENSIN II; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID PHOSPHATE; MEVALONIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ADHESION; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; METABOLISM; MONOCYTE; PROTEIN PROCESSING; UMBILICAL VEIN;

ANGIOTENSIN II; CELL ADHESION; CELL LINE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MONOCYTES; NADPH OXIDASE; POLYISOPRENYL PHOSPHATES; PROTEIN PRENYLATION; REACTIVE OXYGEN SPECIES; SIMVASTATIN; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 42949159897     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1141-2     Document Type: Article

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