Do intra-tumor alkaline micro-regions represent additional therapeutically privileged sites?

Medical Hypotheses

Volumn 70, Issue 6, 2008, Pages 1193-1196

  Anderson, K M ^a   Jajeh, A ^a   Guinan, P ^a   Tsui, P ^a   Rubenstein, M ^a  

^a HEKTOEN INSTITUTE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ALKALINITY; ANOXIA; ARTICLE; CANCER RESISTANCE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; HUMAN; HYPOXIA; MITOCHONDRION; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANOXIA; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL HYPOXIA; CELL PROLIFERATION; CELL RESPIRATION; CLONE CELLS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLYCOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE PROTEINS; MITOCHONDRIA; MODELS, BIOLOGICAL; NEOPLASMS; NEOPLASTIC STEM CELLS;

EID: 42749093135     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.09.016     Document Type: Article

References (19)

1. Graeber T.G., Osmanian C., Jacks T., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379 (1996) 88-91
2. Jones R.J., Matsui W.H., and Smith B.D. Cancer stem cells: an old idea - A paradigm shift. Am Assoc Cancer Res 66 (2006) 1883-1890
3. Anderson K.M., Tsui P., Guinan P., and Rubenstein M. To what extent are the sets of biologic properties expressed by hypoxic cancer cells and by cancer stem cells equivalent, intersecting, disjoint or complementary? Some implications for the design of cancer therapies. Med Hypo 68 (2007) 166-168
4. Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat Rev Can 4 (2004) 891-899
5. Airley R.E., Monaghan J.E., and Stratford I.J. Hypoxia and disease: opportunities for novel diagnostic and therapeutic prodrug strategies. Pharmacol J 264 (2000) 666-673
6. Schumacker P.T. Hypoxia, anoxia and O2 sensing: the search continues. Am J Lung Cell Mol Physiol 283 (2002) L918-L921
7. Altman P.L., and Katz D.D. Cell biology I (1976), FASEB, Bethesda, MD p. 59-61 [Effects of carbon dioxide concentrations on vertebrate cell tissue culture]
8. Tannock I.F., and Rotin D. Acid pH in tumors and its potential for therapeutic exploitation. Can Res 49 (1989) 4373-4384
9. Schmaltz C., Harrigan Hardenbergh P., Wells A., and Fisher D.E. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol Cell Biol 18 (1998) 2845-2854
10. 2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation. Nat Med 3 (1997) 177-182
11. Cho G.L., and Dewey W.C. The role of low intracellular or extracellular pH in sensitization to hyperthermia. Rad Res 114 (1988) 154-167
12. Peak M., al-Habori M., and Agius L. Regulation of glycogen synthesis and glycolysis by insulin, pH and cell volume. Interactions between swelling and alkaline pH in mediating the effects of insulin. Bio J 282 (1992) 797-805
13. Putney L.K., and Barber D.L. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. JBC 278 (2003) 44645-44649
14. Freshney R.I. Culture of Animal Cells. 4th ed. (2000), Springer, NY, Chichester pp. 90-91, chapter 8, Media
15. Kim J.-w., Tchernnyshyov I., Semenza G., and Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cell hypoxia. Cell Metab 3 (2006) 177-185
16. Papandreou I., Cairns R.A., Fontana L., et al. HIF-1 mediates adaptation to hypoxia by actively down-regulating mitochondrial oxygen consumption. Cancer Cell 3 (2007) 187-197
17. Bonnet S., Archer S.L., Allalunis-Turner J., et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 (2007) 37-51
18. Chen Z., Odstrcil E.A., Tu B.P., and McKnight S.L. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science 316 (2007) 1916-1919
19. Landry C.R., Lemos B., Rifkin S.A., et al. Genetic properties influencing the evolvability of gene expression. Science 317 (2007) 118-121