To what extent are the "sets" of biologic properties expressed by hypoxic cancer cells and by cancer "stem" cells equivalent, intersecting, disjoint or complementary? Some implications for the design of cancer therapies

Medical Hypotheses

Volumn 68, Issue 1, 2007, Pages 166-168

  Anderson, K M ^a   Tsui, P ^a,b   Guinan, P ^a,b   Rubenstein, M ^a,b  

^a Hektoen Research Institute   (United States)

^b Jr Hospital of Cook County   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ANTIBODY;

ARTICLE; BIOCHEMICAL COMPOSITION; BIOLOGICAL ACTIVITY; CANCER CELL; CANCER STEM CELL; CANCER THERAPY; HUMAN; HYPOXIC CELL; PRIORITY JOURNAL; TREATMENT PLANNING;

EID: 33750633941     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.05.061     Document Type: Article

References (13)

1. DeVita V.T., Hellman S., and Rosenberg S.A. Cancer, principles and practice of oncology vols. 1 and 2 (2005), Williams and Wilkins, Lippincott Numerous discussions of resistance to cancer therapies are included in these volumes, best searched by specific topic.
2. Jones R.J., Matsui W.H., and Smith B.D. Cancer stem cells: are we missing the target?. J N C I 96 (2004) 583-585
3. Wicha M.S., Liu S., and Dontu G. Cancer stem cells: an old idea - A paradigm shift. Am Assoc Can Res 66 (2006) 1883-1890
4. Kung A.L., Wang S., Klco J.M., Kaelin W.G., and Livingston D.M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat. Med 6 (2000) 1335-1340
5. Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8 Suppl. 4 (2002) S62-S67
6. Appendix E: Stem cell markers - How do researchers use markers to identify stem cells? Stem cell information. NIH resources for stem cell research. Available from http://stemcells.nih.gov/info/scireport/appendixe.asp.
7. Huang L.E., and Bunn H.F. Hypoxia-inducible factor and its biomedical relevance. J B C 278 (2003) 19575-19578
8. Koong A.C., Denko N.C., Hudson K.M., et al. Candidate genes for the hypoxic tumor phenotype. Can Res 60 (2000) 883-887
9. Graeber T.G., Osmanian C., Jacks T., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379 (1996) 88-91
10. Macpherson G.R., and Figg W.D. Small molecule-mediated anti-cancer therapy of hypoxia-inducible factor-1 blockade. Can Biol Ther 3 (2004) 503-504
11. Kemeny J.G., Snell J.L., and Thompson G.L. Introduction to finite mathematics (1966), Prentice Hall
12. Fink T., Abildtrup L., Fogd K., et al. Induction of adipocyte-like phenotype in human mesenchymal cells by hypoxia. Stem Cells 22 (2004) 1346-1355
13. DiCarlo A., De Mori R., Martelli F., et al. Hypoxia inhibits myopgenic differentiation through accelerated MyoD degradation. J B C 279 (2004) 16332-16338