Inhibition of glycogen synthase kinase-3 reduces l-DOPA-induced neurotoxicity

Toxicology

Volumn 247, Issue 2-3, 2008, Pages 112-118

  Koh, Seong Ho ^a   Song, Chiwon ^b   Noh, Min Young ^a   Kim, Hyun Young ^a   Lee, Kyu Yong ^a   Lee, Young Joo ^a   Kim, Juhan ^a   Kim, Seung Hyun ^a   Kim, Hee Tae ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

Glycogen synthase kinase 3; l DOPA; Neurotoxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; HEAT SHOCK TRANSCRIPTION FACTOR 1; LEVODOPA; LITHIUM CHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRYPAN BLUE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; STAINING;

ANIMALS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FREE RADICALS; GLYCOGEN SYNTHASE KINASE 3; LEVODOPA; NEURONS; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 42749091984     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.02.007     Document Type: Article

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