-
1
-
-
42649095464
-
-
World Health Report - 2007, from the World Health Organization. International Cardiovascular Disease Statistics (2007 Update), a publication from the American Heart Association.
-
World Health Report - 2007, from the World Health Organization. International Cardiovascular Disease Statistics (2007 Update), a publication from the American Heart Association.
-
-
-
-
2
-
-
26444446961
-
Estrogen receptor alpha gene variation and the risk of stroke
-
Shearman AM, Cooper JA, Kotwinski PJ, et al. Estrogen receptor alpha gene variation and the risk of stroke. Stroke 2005;36(10):2281-2
-
(2005)
Stroke
, vol.36
, Issue.10
, pp. 2281-2282
-
-
Shearman, A.M.1
Cooper, J.A.2
Kotwinski, P.J.3
-
3
-
-
0037153037
-
Transient ischemic attack - proposal for a new definition
-
Albers GW, Caplan LR, Easton JD, et al. Transient ischemic attack - proposal for a new definition. N Engl J Med 2002;347(21):1713-6
-
(2002)
N Engl J Med
, vol.347
, Issue.21
, pp. 1713-1716
-
-
Albers, G.W.1
Caplan, L.R.2
Easton, J.D.3
-
4
-
-
84984763363
-
Mechanisms, challenges and opportunities in stroke
-
Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003;4(5):399-415
-
(2003)
Nat Rev Neurosci
, vol.4
, Issue.5
, pp. 399-415
-
-
Lo, E.H.1
Dalkara, T.2
Moskowitz, M.A.3
-
5
-
-
33846857559
-
Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics - 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007;115(5):e69-171
-
(2007)
Circulation
, vol.115
, Issue.5
-
-
Rosamond, W.1
Flegal, K.2
Friday, G.3
-
6
-
-
0035937129
-
Prevalence of disabilities and associated health conditions among adults - United States, 1999
-
McNeil JM, Binette J. Prevalence of disabilities and associated health conditions among adults - United States, 1999. MMWR Morb Mortal Wkly Rep 2001;50(7):120-5
-
(2001)
MMWR Morb Mortal Wkly Rep
, vol.50
, Issue.7
, pp. 120-125
-
-
McNeil, J.M.1
Binette, J.2
-
7
-
-
33644849222
-
Heart disease and stroke statistics - 2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics - 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113(6):e85-151
-
(2006)
Circulation
, vol.113
, Issue.6
-
-
Thom, T.1
Haase, N.2
Rosamond, W.3
-
9
-
-
34548238171
-
Safety and tolerability of NXY-059 for acute intracerebral hemorrhage. The CHANT Trial
-
Lyden PD, Shuaib A, Lees KR, et al. Safety and tolerability of NXY-059 for acute intracerebral hemorrhage. The CHANT Trial Stroke 2007;38(8):2262-69
-
(2007)
Stroke
, vol.38
, Issue.8
, pp. 2262-2269
-
-
Lyden, P.D.1
Shuaib, A.2
Lees, K.R.3
-
10
-
-
0028064265
-
Spectrum of primary intracerebral haemorrhage in Perth, Western Australia, 1989-90: Incidence and outcome
-
Anderson CS, Chakera TM, Stewart-Wynne EG, Jamrozik KD. Spectrum of primary intracerebral haemorrhage in Perth, Western Australia, 1989-90: incidence and outcome. J Neurol Neurosurg Psychiatry 1994;57(8):936-40
-
(1994)
J Neurol Neurosurg Psychiatry
, vol.57
, Issue.8
, pp. 936-940
-
-
Anderson, C.S.1
Chakera, T.M.2
Stewart-Wynne, E.G.3
Jamrozik, K.D.4
-
12
-
-
0034983276
-
Trends in acute ischemic stroke trials through the 20th century
-
Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in acute ischemic stroke trials through the 20th century. Stroke 2001;32(6):1349-59
-
(2001)
Stroke
, vol.32
, Issue.6
, pp. 1349-1359
-
-
Kidwell, C.S.1
Liebeskind, D.S.2
Starkman, S.3
Saver, J.L.4
-
13
-
-
33646411233
-
Reasons why few patients with acute stroke receive tissue plasminogen activator
-
Bambauer KZ, Johnston SC, Bambauer DE, Zivin JA. Reasons why few patients with acute stroke receive tissue plasminogen activator. Arch Neurol 2006;63(5):661-4
-
(2006)
Arch Neurol
, vol.63
, Issue.5
, pp. 661-664
-
-
Bambauer, K.Z.1
Johnston, S.C.2
Bambauer, D.E.3
Zivin, J.A.4
-
14
-
-
34548278923
-
Statin treatment withdrawal in ischemic stroke: A controlled randomized study
-
Blanco M, Nombela F, Castellanos M, et al. Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology 2007;69(9):904-10
-
(2007)
Neurology
, vol.69
, Issue.9
, pp. 904-910
-
-
Blanco, M.1
Nombela, F.2
Castellanos, M.3
-
15
-
-
0028783948
-
Tissue plasminogen activator for acute ischemic stroke
-
The National Institute of Neurological Disorders and Stroke RT-PA Stroke Study Group
-
The National Institute of Neurological Disorders and Stroke RT-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333(24):1581-7
-
(1995)
N Engl J Med
, vol.333
, Issue.24
, pp. 1581-1587
-
-
-
16
-
-
0030911057
-
The International Stroke Trial (IST): A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke
-
and International Stroke Trial Collaborative Group
-
Sandercock PAG and International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997;349(9065):1569-81
-
(1997)
Lancet
, vol.349
, Issue.9065
, pp. 1569-1581
-
-
Sandercock, P.A.G.1
-
17
-
-
34247843020
-
Mechanical thrombectomy of intracranial internal carotid occlusion: Pooled results of the MERCI and Multi MERCI Part I trials
-
Flint AC, Duckwiler GR, Budzik RF, et al. Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and Multi MERCI Part I trials. Stroke 2007;38(4):1274-80
-
(2007)
Stroke
, vol.38
, Issue.4
, pp. 1274-1280
-
-
Flint, A.C.1
Duckwiler, G.R.2
Budzik, R.F.3
-
18
-
-
42649085532
-
-
Available from
-
Health Topics A-Z: Stroke. Available from: http://www.healthywomen.org/ healthtopics/stroke/treatment
-
Health Topics A-Z: Stroke
-
-
-
19
-
-
0025180213
-
Efficacy and safety of vapor-heated anti-inhibitor coagulant complex in hemophilia patients. FEIBA Study Group
-
Hilgartner M, Aledort L, Andes A, Gill J. Efficacy and safety of vapor-heated anti-inhibitor coagulant complex in hemophilia patients. FEIBA Study Group. Transfusion 1990;30(7):626-30
-
(1990)
Transfusion
, vol.30
, Issue.7
, pp. 626-630
-
-
Hilgartner, M.1
Aledort, L.2
Andes, A.3
Gill, J.4
-
20
-
-
0027985567
-
Inhibitors in hemophilia patients: Current status and management
-
Aledort L. Inhibitors in hemophilia patients: current status and management. Am J Hematol 1994;47(3):208-17
-
(1994)
Am J Hematol
, vol.47
, Issue.3
, pp. 208-217
-
-
Aledort, L.1
-
21
-
-
0030837755
-
Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity
-
Negrier C, Goudemand J, Sultan Y, et al. Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity. Thromb Haemost 1997;77(6):1113-9
-
(1997)
Thromb Haemost
, vol.77
, Issue.6
, pp. 1113-1119
-
-
Negrier, C.1
Goudemand, J.2
Sultan, Y.3
-
22
-
-
33644960230
-
-
Available from
-
Subarachnoid Hemorrhage. Available from: http://www.emedicine.com/med/ topic2883.htm
-
Subarachnoid Hemorrhage
-
-
-
24
-
-
2942538277
-
Hypoxic tissue in ischaemic stroke: Persistence and clinical consequences of spontaneous survival
-
Markus R, Reutens DC, Kazui S, et al. Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival. Brain 2004;127(Pt 6):1427-36
-
(2004)
Brain
, vol.127
, Issue.PART 6
, pp. 1427-1436
-
-
Markus, R.1
Reutens, D.C.2
Kazui, S.3
-
25
-
-
13844258517
-
Clinical trials for cytoprotection in stroke
-
Labiche LA, Grotta JC. Clinical trials for cytoprotection in stroke. NeuroRx 2004;1(1):46-70
-
(2004)
NeuroRx
, vol.1
, Issue.1
, pp. 46-70
-
-
Labiche, L.A.1
Grotta, J.C.2
-
26
-
-
19544376511
-
Neuroprotection for ischemic stroke: Two decades of success and failure
-
Cheng YD, Al-Khoury L, Zivin JA, Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 2004;1(1):36-45
-
(2004)
NeuroRx
, vol.1
, Issue.1
, pp. 36-45
-
-
Cheng, Y.D.1
Al-Khoury, L.2
Zivin, J.A.3
-
27
-
-
0343527329
-
Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: A possible involvement of a highly voltage-dependent blockade of Ca(2+) channel
-
Oka M, Itoh Y, Ukai Y. Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: a possible involvement of a highly voltage-dependent blockade of Ca(2+) channel. J Pharmacol Exp Ther 2000;293(2):522-9
-
(2000)
J Pharmacol Exp Ther
, vol.293
, Issue.2
, pp. 522-529
-
-
Oka, M.1
Itoh, Y.2
Ukai, Y.3
-
28
-
-
12844259424
-
2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits
-
2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 2005;129(2):364-71
-
(2005)
J Thorac Cardiovasc Surg
, vol.129
, Issue.2
, pp. 364-371
-
-
Shi, E.1
Kazui, T.2
Jiang, X.3
-
29
-
-
0035052573
-
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
-
Gribkoff VK, Starrett JE Jr, Dworetzky SI, et al. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat Med 2001;7(4):471-7
-
(2001)
Nat Med
, vol.7
, Issue.4
, pp. 471-477
-
-
Gribkoff, V.K.1
Starrett Jr, J.E.2
Dworetzky, S.I.3
-
30
-
-
35748952677
-
-
Available from
-
Stroke Trials Registry. Available from: http://www.strokecenter.org/ trials
-
Stroke Trials Registry
-
-
-
31
-
-
0035895728
-
Real-time measurement of glutamate release from the ischemic penumbra of the rat cerebral cortex using a focal middle cerebral artery occlusion model
-
Guyot LL, Diaz FG, O'Regan MH, et al. Real-time measurement of glutamate release from the ischemic penumbra of the rat cerebral cortex using a focal middle cerebral artery occlusion model. Neurosci Lett 2001;299(1/ 2):37-40
-
(2001)
Neurosci Lett
, vol.299
, Issue.1-2
, pp. 37-40
-
-
Guyot, L.L.1
Diaz, F.G.2
O'Regan, M.H.3
-
32
-
-
0028897733
-
Clinical experience with excitatory amino acid antagonist drugs
-
Muir KW, Lees KR. Clinical experience with excitatory amino acid antagonist drugs. Stroke 1995;26(3):503-13
-
(1995)
Stroke
, vol.26
, Issue.3
, pp. 503-513
-
-
Muir, K.W.1
Lees, K.R.2
-
33
-
-
0033387727
-
An open-label study of CP-101,606 in subjects with a severe traumatic head injury or spontaneous intracerebral hemorrhage
-
Bullock MR, Merchant RE, Carmack CA, et al. An open-label study of CP-101,606 in subjects with a severe traumatic head injury or spontaneous intracerebral hemorrhage. Ann NY Acad Sci 1999;890:51-8
-
(1999)
Ann NY Acad Sci
, vol.890
, pp. 51-58
-
-
Bullock, M.R.1
Merchant, R.E.2
Carmack, C.A.3
-
34
-
-
0033392424
-
A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury
-
Merchant RE, Bullock MR, Carmack CA, et al. A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury Ann NY Acad Sci 1999;890:42-50
-
(1999)
Ann NY Acad Sci
, vol.890
, pp. 42-50
-
-
Merchant, R.E.1
Bullock, M.R.2
Carmack, C.A.3
-
35
-
-
0032543159
-
A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats
-
Kawasaki-Yatsugi S, Yatsugi S, Takahashi M, et al. A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats. Brain Res 1998;793(1/2):39-46
-
(1998)
Brain Res
, vol.793
, Issue.1-2
, pp. 39-46
-
-
Kawasaki-Yatsugi, S.1
Yatsugi, S.2
Takahashi, M.3
-
36
-
-
0031667548
-
YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats
-
Shimizu-Sasamata M, Kano T, Rogowska J, et al. YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats. Stroke 1998;29(10):2141-8
-
(1998)
Stroke
, vol.29
, Issue.10
, pp. 2141-2148
-
-
Shimizu-Sasamata, M.1
Kano, T.2
Rogowska, J.3
-
37
-
-
0033988426
-
Neuroprotective effects of an AMPA receptor antagonist YM872 in a rat transient middle cerebral artery occlusion model
-
Kawasaki-Yatsugi S, Ichiki C, Yatsugi S, et al. Neuroprotective effects of an AMPA receptor antagonist YM872 in a rat transient middle cerebral artery occlusion model. Neuropharmacology 2000;39(2):211-7
-
(2000)
Neuropharmacology
, vol.39
, Issue.2
, pp. 211-217
-
-
Kawasaki-Yatsugi, S.1
Ichiki, C.2
Yatsugi, S.3
-
38
-
-
0036871758
-
Magnesium in stroke treatment
-
Muir KW. Magnesium in stroke treatment. Postgrad Med J 2002;78(925):641-5
-
(2002)
Postgrad Med J
, vol.78
, Issue.925
, pp. 641-645
-
-
Muir, K.W.1
-
40
-
-
0025039488
-
Effects of magnesium sulfate and nifedipine on regional cerebral blood flow during middle cerebral artery ligation in the rat
-
Chi OZ, Pollak P, Weiss HR. Effects of magnesium sulfate and nifedipine on regional cerebral blood flow during middle cerebral artery ligation in the rat. Arch Int Pharmacodyn Ther 1990;304:196-205
-
(1990)
Arch Int Pharmacodyn Ther
, vol.304
, pp. 196-205
-
-
Chi, O.Z.1
Pollak, P.2
Weiss, H.R.3
-
41
-
-
0029991515
-
Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia
-
Marinov MB, Harbaugh KS, Hoopes PJ, et al. Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia. J Neurosurg 1996;85(1):117-24
-
(1996)
J Neurosurg
, vol.85
, Issue.1
, pp. 117-124
-
-
Marinov, M.B.1
Harbaugh, K.S.2
Hoopes, P.J.3
-
42
-
-
0034640147
-
Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat
-
Yang Y, Li Q, Ahmad F, Shuaib A. Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat. Neurosci Lett 2000;285(2):119-22
-
(2000)
Neurosci Lett
, vol.285
, Issue.2
, pp. 119-122
-
-
Yang, Y.1
Li, Q.2
Ahmad, F.3
Shuaib, A.4
-
43
-
-
0029067191
-
A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke
-
Muir KW, Lees KR. A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke 1995;26(7):1183-8
-
(1995)
Stroke
, vol.26
, Issue.7
, pp. 1183-1188
-
-
Muir, K.W.1
Lees, K.R.2
-
44
-
-
2942700683
-
Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke Trial): Randomised controlled trial
-
Muir KW, Lees KR, Ford I, Davis S. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke Trial): randomised controlled trial. Lancet 2004;363(9407):439-45
-
(2004)
Lancet
, vol.363
, Issue.9407
, pp. 439-445
-
-
Muir, K.W.1
Lees, K.R.2
Ford, I.3
Davis, S.4
-
45
-
-
0023887866
-
Oxygen free radical involvement in ischemia and reperfusion injury to brain
-
Cao W, Carney JM, Duchon A, et al. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 1988;88(2):233-8
-
(1988)
Neurosci Lett
, vol.88
, Issue.2
, pp. 233-238
-
-
Cao, W.1
Carney, J.M.2
Duchon, A.3
-
47
-
-
0142139346
-
Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia
-
Sugawara T, Chan PH. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 2003;5(5):597-607
-
(2003)
Antioxid Redox Signal
, vol.5
, Issue.5
, pp. 597-607
-
-
Sugawara, T.1
Chan, P.H.2
-
48
-
-
0029433307
-
Inhibition of lipid peroxidation in central nervous system trauma and ischemia
-
Hall ED. Inhibition of lipid peroxidation in central nervous system trauma and ischemia. J Neurol Sci 1995;134(Suppl):79-83
-
(1995)
J Neurol Sci
, vol.134
, Issue.SUPPL.
, pp. 79-83
-
-
Hall, E.D.1
-
49
-
-
0035148402
-
-
Lapchak PA, Chapman DF, Zivin JA. Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 2001;32(1):147-53
-
Lapchak PA, Chapman DF, Zivin JA. Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 2001;32(1):147-53
-
-
-
-
50
-
-
0033816426
-
Tirilazad mesylate in acute ischemic stroke: A systematic review
-
Tirilazad International Steering Committee
-
Tirilazad International Steering Committee. Tirilazad mesylate in acute ischemic stroke: a systematic review. Stroke 2000;31(9):2257-65
-
(2000)
Stroke
, vol.31
, Issue.9
, pp. 2257-2265
-
-
-
51
-
-
0033772990
-
Role of neuroprotective drugs in acute ischemic stroke
-
Venti M, Parnetti L, Silvestrelli G, Gallai V. Role of neuroprotective drugs in acute ischemic stroke. Cerebrovasc Dis 2000;10(Suppl 4):24-6
-
(2000)
Cerebrovasc Dis
, vol.10
, Issue.SUPPL. 4
, pp. 24-26
-
-
Venti, M.1
Parnetti, L.2
Silvestrelli, G.3
Gallai, V.4
-
52
-
-
0035800578
-
NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat
-
Zhao Z, Cheng M, Maples KR, et al. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat. Brain Res 2001;909(1/2):46-50
-
(2001)
Brain Res
, vol.909
, Issue.1-2
, pp. 46-50
-
-
Zhao, Z.1
Cheng, M.2
Maples, K.R.3
-
53
-
-
0036152938
-
Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window
-
Sydserff SG, Borelli AR, Green AR, Cross AJ. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br J Pharmacol 2002;135(1):103-12
-
(2002)
Br J Pharmacol
, vol.135
, Issue.1
, pp. 103-112
-
-
Sydserff, S.G.1
Borelli, A.R.2
Green, A.R.3
Cross, A.J.4
-
54
-
-
0035154631
-
NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
-
Marshall JW, Duffin KJ, Green AR, Ridley RM. NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001;32(1):190-8
-
(2001)
Stroke
, vol.32
, Issue.1
, pp. 190-198
-
-
Marshall, J.W.1
Duffin, K.J.2
Green, A.R.3
Ridley, R.M.4
-
55
-
-
0036152938
-
Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window
-
Sydserff SG, Borelli AR, Green AR, Cross AJ. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br J Pharmacol 2002;135(1):103-12
-
(2002)
Br J Pharmacol
, vol.135
, Issue.1
, pp. 103-112
-
-
Sydserff, S.G.1
Borelli, A.R.2
Green, A.R.3
Cross, A.J.4
-
56
-
-
32144453826
-
NXY-059 for acute ischemic stroke
-
Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med 2006;354(6):588-600
-
(2006)
N Engl J Med
, vol.354
, Issue.6
, pp. 588-600
-
-
Lees, K.R.1
Zivin, J.A.2
Ashwood, T.3
-
57
-
-
34547795720
-
NXY-059 for the treatment of acute ischemic stroke
-
Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 2007;357(6):562-71
-
(2007)
N Engl J Med
, vol.357
, Issue.6
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
-
59
-
-
0036281518
-
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
-
Jin YJ, Mima T, Raicu V, et al. Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neurosci Res 2002;43(1):75-9
-
(2002)
Neurosci Res
, vol.43
, Issue.1
, pp. 75-79
-
-
Jin, Y.J.1
Mima, T.2
Raicu, V.3
-
60
-
-
39349091206
-
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
-
Nakamura T, Kuroda Y, Yamashita S, et al. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke 2008;39(2):463-9
-
(2008)
Stroke
, vol.39
, Issue.2
, pp. 463-469
-
-
Nakamura, T.1
Kuroda, Y.2
Yamashita, S.3
-
61
-
-
2642551352
-
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion
-
Toyoda K, Fujii K, Kamouchi M, et al. Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci 2004;221(1/2):11-7
-
(2004)
J Neurol Sci
, vol.221
, Issue.1-2
, pp. 11-17
-
-
Toyoda, K.1
Fujii, K.2
Kamouchi, M.3
-
62
-
-
0037229213
-
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
-
The Edaravone Acute Brain Infarction Study Group
-
The Edaravone Acute Brain Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003;15(3):222-9
-
(2003)
Cerebrovasc Dis
, vol.15
, Issue.3
, pp. 222-229
-
-
-
63
-
-
34250760916
-
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
-
Higashi Y, Jitsuikia D, Chayamab K, Yoshizumia M. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Patents Cardiovasc Drug Discovery 2006;1:85-93
-
(2006)
Recent Patents Cardiovasc Drug Discovery
, vol.1
, pp. 85-93
-
-
Higashi, Y.1
Jitsuikia, D.2
Chayamab, K.3
Yoshizumia, M.4
-
64
-
-
0022449111
-
Opiate-antagonist reversal of neurological deficits - experimental and clinical studies
-
Namba S, Nishigaki S, Fujiwara N, et al. Opiate-antagonist reversal of neurological deficits - experimental and clinical studies. Jpn J Psychiatry Neurol 1986;40(1):61-79
-
(1986)
Jpn J Psychiatry Neurol
, vol.40
, Issue.1
, pp. 61-79
-
-
Namba, S.1
Nishigaki, S.2
Fujiwara, N.3
-
65
-
-
0027749487
-
Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia
-
Graham SH, Shimizu H, Newman A, et al. Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia. Brain Res 1993;632(1/2):346-50
-
(1993)
Brain Res
, vol.632
, Issue.1-2
, pp. 346-350
-
-
Graham, S.H.1
Shimizu, H.2
Newman, A.3
-
66
-
-
0034034434
-
Cervene (nalmefene) in acute ischemic stroke: Final results of a Phase III efficacy study. The Cervene Stroke Study Investigators
-
Clark WM, Raps EC, Tong DC, Kelly RE. Cervene (nalmefene) in acute ischemic stroke: final results of a Phase III efficacy study. The Cervene Stroke Study Investigators. Stroke 2000;31(6):1234-9
-
(2000)
Stroke
, vol.31
, Issue.6
, pp. 1234-1239
-
-
Clark, W.M.1
Raps, E.C.2
Tong, D.C.3
Kelly, R.E.4
-
67
-
-
0034078117
-
GABA potentiation: A logical pharmacological approach for the treatment of acute ischaemic stroke
-
Green AR, Hainsworth AH, Jackson DM. GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology 2000;39(9):1483-94
-
(2000)
Neuropharmacology
, vol.39
, Issue.9
, pp. 1483-1494
-
-
Green, A.R.1
Hainsworth, A.H.2
Jackson, D.M.3
-
68
-
-
0024517681
-
Chlormethiazole: Neurochemical actions at the gamma-aminobutyric acid receptor complex
-
Moody EJ, Skolnick P. Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex. Eur J Pharmacol 1989;164(1):153-8
-
(1989)
Eur J Pharmacol
, vol.164
, Issue.1
, pp. 153-158
-
-
Moody, E.J.1
Skolnick, P.2
-
69
-
-
0026094214
-
Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil
-
Cross AJ, Jones JA, Baldwin HA, Green AR. Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil. Br J Pharmacol 1991;104(2):406-11
-
(1991)
Br J Pharmacol
, vol.104
, Issue.2
, pp. 406-411
-
-
Cross, A.J.1
Jones, J.A.2
Baldwin, H.A.3
Green, A.R.4
-
70
-
-
18244392468
-
Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): Final results
-
Lyden P, Shuaib A, Ng K, et al. Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results. Stroke 2002;33(1):122-8
-
(2002)
Stroke
, vol.33
, Issue.1
, pp. 122-128
-
-
Lyden, P.1
Shuaib, A.2
Ng, K.3
-
71
-
-
0033773007
-
Diazepam treatment to increase the cerebral GABAergic activity in acute stroke: A feasibility study in 104 patients
-
Lodder J, Luijckx G, Van Raak L, Kessels F. Diazepam treatment to increase the cerebral GABAergic activity in acute stroke: a feasibility study in 104 patients. Cerebrovasc Dis 2000;10(6):437-40
-
(2000)
Cerebrovasc Dis
, vol.10
, Issue.6
, pp. 437-440
-
-
Lodder, J.1
Luijckx, G.2
Van Raak, L.3
Kessels, F.4
-
72
-
-
30944463969
-
Diazepam to improve acute stroke outcome: Results of the early GABA-Ergic activation study in stroke trial. A randomized double-blind placebo-controlled trial
-
Lodder J, Van Raak L, Hilton A, et al. Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. A randomized double-blind placebo-controlled trial. Cerebrovasc Dis 2006;21(1/2):120-7
-
(2006)
Cerebrovasc Dis
, vol.21
, Issue.1-2
, pp. 120-127
-
-
Lodder, J.1
Van Raak, L.2
Hilton, A.3
-
73
-
-
0028896412
-
Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline
-
Weiss GB. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci 1995;56(9):637-60
-
(1995)
Life Sci
, vol.56
, Issue.9
, pp. 637-660
-
-
Weiss, G.B.1
-
74
-
-
0342936464
-
The effects of prolonged treatment with citicoline in temporary experimental focal ischemia
-
Schabitz WR, Weber J, Takano K, et al. The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J Neurol Sci 1996;138(1/2):21-5
-
(1996)
J Neurol Sci
, vol.138
, Issue.1-2
, pp. 21-25
-
-
Schabitz, W.R.1
Weber, J.2
Takano, K.3
-
75
-
-
0035856456
-
A Phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients
-
Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE. A Phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 2001;57(9):1595-602
-
(2001)
Neurology
, vol.57
, Issue.9
, pp. 1595-1602
-
-
Clark, W.M.1
Wechsler, L.R.2
Sabounjian, L.A.3
Schwiderski, U.E.4
-
76
-
-
0030991736
-
Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury
-
Cheng Y, Gidday JM, Yan Q, et al. Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann Neurol 1997;41(4):521-9
-
(1997)
Ann Neurol
, vol.41
, Issue.4
, pp. 521-529
-
-
Cheng, Y.1
Gidday, J.M.2
Yan, Q.3
-
77
-
-
0030053351
-
Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury
-
Holtzman DM, Sheldon RA, Jaffe W, et al. Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 1996;39(1):114-22
-
(1996)
Ann Neurol
, vol.39
, Issue.1
, pp. 114-122
-
-
Holtzman, D.M.1
Sheldon, R.A.2
Jaffe, W.3
-
78
-
-
0036968150
-
Fiblast (trafermin) in acute stroke: Results of the European-Australian Phase II/III safety and efficacy trial
-
Bogousslavsky J, Victor SJ, Salinas EO, et al. Fiblast (trafermin) in acute stroke: results of the European-Australian Phase II/III safety and efficacy trial. Cerebrovasc Dis 2002;14(3-4):239-51
-
(2002)
Cerebrovasc Dis
, vol.14
, Issue.3-4
, pp. 239-251
-
-
Bogousslavsky, J.1
Victor, S.J.2
Salinas, E.O.3
-
79
-
-
42649127211
-
-
Available from
-
Available from: http://clinicaltrials.gov/ct/show/NCT00229177
-
-
-
-
80
-
-
0035133027
-
Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window
-
Belayev L, Liu Y, Zhao W, et al. Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke 2001;32(2):553-60
-
(2001)
Stroke
, vol.32
, Issue.2
, pp. 553-560
-
-
Belayev, L.1
Liu, Y.2
Zhao, W.3
-
81
-
-
10344266010
-
Serum albumin is a specific inhibitor of apoptosis in human endothelial cells
-
Zoellner H, Hofler M, Beckmann R, et al. Serum albumin is a specific inhibitor of apoptosis in human endothelial cells. J Cell Sci 1996;109(Pt 10):2571-80
-
(1996)
J Cell Sci
, vol.109
, Issue.PART 10
, pp. 2571-2580
-
-
Zoellner, H.1
Hofler, M.2
Beckmann, R.3
-
82
-
-
0036828345
-
Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin
-
Rodriguez De Turco EB, Belayev L, Liu Y, et al. Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. J Neurochem 2002;83(3):515-24
-
(2002)
J Neurochem
, vol.83
, Issue.3
, pp. 515-524
-
-
Rodriguez De Turco, E.B.1
Belayev, L.2
Liu, Y.3
-
83
-
-
24644455227
-
High dose human serum albumin for the treatment of acute ischemic stroke: A safety study
-
Koch S, Concha M, Wazzan T, et al. High dose human serum albumin for the treatment of acute ischemic stroke: a safety study. Neurocrit Care 2004;1(3):335-41
-
(2004)
Neurocrit Care
, vol.1
, Issue.3
, pp. 335-341
-
-
Koch, S.1
Concha, M.2
Wazzan, T.3
-
84
-
-
33747195315
-
The ALIAS Pilot Trial: A dose-escalation and safety study of albumin therapy for acute ischemic stroke - I: physiological responses and safety results
-
Ginsberg MD, Hill MD, Palesch YY, et al. The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke - I: physiological responses and safety results. Stroke 2006;37(8):2100-6
-
(2006)
Stroke
, vol.37
, Issue.8
, pp. 2100-2106
-
-
Ginsberg, M.D.1
Hill, M.D.2
Palesch, Y.Y.3
-
85
-
-
34248639061
-
The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: Design and progress report
-
Ginsberg MD, Palesch YY, Hill MD. The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report. Biochem Soc Trans 2006;34(Pt 6):1323-6
-
(2006)
Biochem Soc Trans
, vol.34
, Issue.PART 6
, pp. 1323-1326
-
-
Ginsberg, M.D.1
Palesch, Y.Y.2
Hill, M.D.3
-
86
-
-
33747155340
-
The ALIAS Pilot Trial: A dose-escalation and safety study of albumin therapy for acute ischemic stroke - II: neurologic outcome and efficacy analysis
-
Palesch YY, Hill MD, Ryckborst KJ, et al. The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke - II: neurologic outcome and efficacy analysis. Stroke 2006;37(8):2107-14
-
(2006)
Stroke
, vol.37
, Issue.8
, pp. 2107-2114
-
-
Palesch, Y.Y.1
Hill, M.D.2
Ryckborst, K.J.3
-
87
-
-
33847321604
-
Therapeutic hypothermia in acute ischemic stroke
-
Den Hertog H, Van Der Worp B, Van Gemert M, Dippel D. Therapeutic hypothermia in acute ischemic stroke. Expert Rev Neurother 2007;7(2):155-64
-
(2007)
Expert Rev Neurother
, vol.7
, Issue.2
, pp. 155-164
-
-
Den Hertog, H.1
Van Der Worp, B.2
Van Gemert, M.3
Dippel, D.4
-
88
-
-
42649107631
-
-
at stroke prevention and treatment. Available from
-
Brain attack: a look at stroke prevention and treatment. Available from: http://www.fda.gov/fdac/features/2005/205_stroke.html
-
Brain attack: A look
-
-
-
89
-
-
34548491610
-
Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis
-
Van Der Worp HB, Sena ES, Donnan GA, et al. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 2007;130(Pt 12):3063-74
-
(2007)
Brain
, vol.130
, Issue.PART 12
, pp. 3063-3074
-
-
Van Der Worp, H.B.1
Sena, E.S.2
Donnan, G.A.3
-
90
-
-
33846565426
-
Induced hypothermia for acute stroke
-
Hemmen TM, Lyden PD. Induced hypothermia for acute stroke. Stroke 2007;38(2 Suppl):794-9
-
(2007)
Stroke
, vol.38
, Issue.2 SUPPL.
, pp. 794-799
-
-
Hemmen, T.M.1
Lyden, P.D.2
-
91
-
-
40749149164
-
Effect of endovascular hypothermia on acute ischemic edema: Morphometric analysis of the ICTuS Trial
-
Guluma KZ, Oh H, Yu SW, et al. Effect of endovascular hypothermia on acute ischemic edema: morphometric analysis of the ICTuS Trial. Neurocrit Care 2008;8(1):42-7
-
(2008)
Neurocrit Care
, vol.8
, Issue.1
, pp. 42-47
-
-
Guluma, K.Z.1
Oh, H.2
Yu, S.W.3
-
93
-
-
34848820366
-
SAINT-I worked, but the neuroprotectant is not NXY-059
-
author reply e 110
-
Proctor PH, Tamborello LP. SAINT-I worked, but the neuroprotectant is not NXY-059. Stroke 2007;38(10):e109. (author reply e 110)
-
(2007)
Stroke
, vol.38
, Issue.10
-
-
Proctor, P.H.1
Tamborello, L.P.2
-
94
-
-
33846572391
-
Clinical trials of neuroprotective therapies
-
Zivin JA. Clinical trials of neuroprotective therapies. Stroke 2007;38(2 Suppl):791-3
-
(2007)
Stroke
, vol.38
, Issue.2 SUPPL.
, pp. 791-793
-
-
Zivin, J.A.1
-
95
-
-
35448967751
-
Neuroprotection and stroke: Time for a compromise
-
Young AR, Ali C, Duretete A, Vivien D. Neuroprotection and stroke: time for a compromise. J Neurochem 2007;103(4):1302-9
-
(2007)
J Neurochem
, vol.103
, Issue.4
, pp. 1302-1309
-
-
Young, A.R.1
Ali, C.2
Duretete, A.3
Vivien, D.4
-
96
-
-
36349016114
-
NXY-059 for the treatment of stroke
-
author reply 2198-2199
-
Savitz SI, Fisher M. NXY-059 for the treatment of stroke. N Engl J Med 2007;357(21):2198 (author reply 2198-2199)
-
(2007)
N Engl J Med
, vol.357
, Issue.21
, pp. 2198
-
-
Savitz, S.I.1
Fisher, M.2
-
97
-
-
34249942190
-
Future of neuroprotection for acute stroke: In the aftermath of the SAINT trials
-
Savitz SI, Fisher M. Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol 2007;61(5):396-402
-
(2007)
Ann Neurol
, vol.61
, Issue.5
, pp. 396-402
-
-
Savitz, S.I.1
Fisher, M.2
-
98
-
-
34247263212
-
A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke
-
Savitz SI. A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke. Exp Neurol 2007;205(1):20-5
-
(2007)
Exp Neurol
, vol.205
, Issue.1
, pp. 20-25
-
-
Savitz, S.I.1
-
99
-
-
35649012715
-
-
Ginsberg MD. Response to letter by Fisher, et al. Stroke 2007;38(11):e128
-
Ginsberg MD. Response to letter by Fisher, et al. Stroke 2007;38(11):e128
-
-
-
-
100
-
-
41249102422
-
MicroRNA expression in blood and brain of rats subjected to transient focal ischemia
-
Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in blood and brain of rats subjected to transient focal ischemia. Stroke 2008;39(3):959-66
-
(2008)
Stroke
, vol.39
, Issue.3
, pp. 959-966
-
-
Jeyaseelan, K.1
Lim, K.Y.2
Armugam, A.3
|