Hypoxic tissue in ischaemic stroke: Persistence and clinical consequences of spontaneous survival

Brain

Volumn 127, Issue 6, 2004, Pages 1427-1436

  Markus, R ^a,b   Reutens, D C ^a,b   Kazui, S ^a,b   Read, S ^a,b   Wright, P ^a,b   Pearce, D C ^b   Tochon Danguy, H J ^b   Sachinidis, J I ^b   Donnan, Geoffrey A ^a,b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

18F fluoromisonidazole; Hypoxia; Ischaemic stroke; Penumbra; PET

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; MISONIDAZOLE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STROKE; SURVIVAL; VOLUMETRY;

ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MALE; MIDDLE AGED; MISONIDAZOLE; PROGNOSIS; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 2942538277     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh162     Document Type: Article

References (36)

1. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 1981; 12: 723-5.
2. Baird AE, Benfield A, Schlaug G, Siewert B, Lovblad KO, Edelman RR, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 1997; 41: 581-9.
3. Bamford JM, Sandercock PA, Warlow CP, Slattery J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1989; 20: 828.
4. Baron JC. Mapping the ischaemic penumbra with PET: implications for acute stroke treatment. Cerebrovasc Dis 1999; 9: 193-201.
5. Baron JC. Mapping the ischaemic penumbra with PET: a new approach. Brain 2001; 124: 2-4.
6. Chapman JD, Baer K, Lee J. Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells. Cancer Res 1983; 43: 1523-8.
7. DiRocco RJ, Kuczynski BL, Pirro JP, Bauer A, Linder KE, Ramalingam K, et al. Imaging ischemic tissue at risk of infarction during stroke. J Cereb Blood Flow Metab 1993; 13: 755-62.
8. Donnan GA, Davis SM. Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy. Lancet Neurol 2002; 1: 417-25.
9. Fisher M. Characterizing the target of acute stroke therapy. Stroke 1997; 28: 866-72.
10. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 1996; 40: 216-26.
11. Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000; 20: 1276-93.
12. Heiss WD, Huber M, Fink GR, Herholz K, Pietrzyk U, Wagner R, et al. Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 1992; 12: 193-203.
13. Heiss WD, Graf R, Wienhard K, Lottgen J, Saito R, Fujita T, et al. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 1994; 14: 892-902.
14. 3H]misonidazole in cerebral ischemia. Stroke 1987; 18: 168-76.
15. Hossmann KA. Viability thresholds and the penumbra of focal ischemia. Ann Neurol 1994; 36: 557-65.
16. Lyden P, Brott T, Tilley B, Welch KM, Mascha EJ, Levine S, et al. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke 1994; 25: 2220-6.
17. Lythgoe MF, Williams SR, Wiebe LI, McEwan AJ, Gordon I. Autoradiographic imaging of cerebral ischaemia using a combination of blood flow and hypoxic markers in an animal model. Eur J Nucl Med 1997; 24: 16-20.
18. Lythgoe MF, Williams SR, Busza AL, Wiebe L, McEwan AJ, Gadian DG, et al. The relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow and hypoxia in an animal stroke model. Magn Reson Med 1999; 41: 706-14.
19. Mahoney FI, Barthel FW. Functional evaluation: the Barthel Index. MD State Med J 1965; 14: 61-5.
20. Marchal G, Rioux P, Petit-Taboue MC, Sette G, Travere JM, Le Poec C, et al. Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. Arch Neurol 1992; 49: 1013-20.
21. 18F]fluoromisonidazole and positron emission tomography following acute ischemic stroke. Neuroimage 2002; 16: 425-33.
22. Markus R, Reutens DC, Kazui S, Read S, Wright P, Chambers BR, et al. Topography and temporal evolution of hypoxic viable tissue identified by 18F-fluoromisonidazole positron emission tomography in humans after ischemic stroke. Stroke 2003; 34: 2646-52.
23. Nunn A, Linder K, Strauss HW. Nitroimidazoles and imaging hypoxia. Eur J Nucl Med 1995; 22: 265-80.
24. Quast MJ, Huang NC, Hillman GR, Kent TA. The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Reson Imaging 1993; 11: 465-71.
25. Rankin J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 1957; 2: 200-15.
26. Rasey JS, Grunbaum Z, Magee S, Nelson NJ, Olive PL, Durand RE, et al. Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res 1987; 111: 292-304.
27. 18F-fluoromisonidazole. Neurology 1998; 51: 1617-21.
28. 18F-fluoromisonidazole positron emission tomography after ischemic stroke. Ann Neurol 2000; 48: 228-35.
29. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. Stuttgart: Thieme; 1988.
30. Touzani O, Young AR, Derlon JM, Beaudouin V, Marchal G, Rioux P, et al. Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion. A positron emission tomographic investigation in anesthetized baboons. Stroke 1995; 26: 2112-9.
31. Touzani O, Roussel S, MacKenzie ET. The ischaemic penumbra. Curr Opin Neurol 2001; 14: 83-8.
32. vanderWorp HB, Claus SP, Bar PR, Ramos LM, Algra A, van Gijn J, et al. Reproducibility of measurements of cerebral infarct volume on CT scans. Stroke 2001; 32: 424-30.
33. Wintermark M, Reichhart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, et al. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002; 51: 417-32.
34. Wityk RJ, Pessin MS, Kaplan RF, Caplan LR. Serial assessment of acute stroke using the NIH Stroke Scale. Stroke 1994; 25: 362-5.
35. Woods RP, Grafton ST, Watson JD, Sicotte NL, Mazziotta JC. Automated image registration: II. Intersubject validation of linear and nonlinear models. J Comput Assist Tomogr 1998; 22: 153-65.
36. Worsley KJ, Marrett S, Neelin P, Vandal S, Friston KJ, Evans AC. A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 1996; 4: 58-73.