Spatiotemporal patterns of postsynaptic density (PSD)-95 expression after rat spinal cord injury

Neuropathology and Applied Neurobiology

Volumn 34, Issue 3, 2008, Pages 340-356

  Cheng, C ^a   Gao, S ^a   Zhao, J ^a   Niu, S ^a   Chen, M ^a   Li, X ^a   Qin, J ^a   Shi, S ^a   Guo, Z ^a   Shen, A ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Neuronal nitric oxide synthase; Postsynaptic density 95; Rat; Real time polymerase chain reaction; Spinal cord

Indexed keywords

MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; POSTSYNAPTIC DENSITY PROTEIN 95; TAU PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CASPASE 3; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD INJURIES;

EID: 42549141592     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2007.00917.x     Document Type: Article

References (56)

1. Dumont RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala DB, Dumont AS. Acute spinal cord injury, Part I: pathophysiologic mechanisms. Clin Neuropharmacol 2001 24 : 254 64
2. Demopoulos HB, Flamm ES, Seligman ML, Mitamura JA, Ransohoff J. Membrane perturbations in central nervous system injury: theoretical basis for free radical damage and a review of the experimental data. In Neural Trauma. AJ Popp. New York : Raven Press, 1979 63 78
3. Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 2004 21 : 754 74
4. Lu J, Ashwell KW, Waite P. Advances in secondary spinal cord injury: role of apoptosis. Spine 2000 25 : 1859 66
5. Giannakopoulou M, Mansour M, Kazanis E, Bozas E, Philpipidis H, Stylianopoulou F. NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide. Neuropathol Appl Neurobiol 2000 26 : 513 21
6. Matsuyama Y, Sato K, Kamiya M, Yano J, Iwata H, Isobe KI. Nitric oxide: a possible etiologic factor in spinal cord cavitation. J Spinal Disord 1998 11 : 248 52
7. Griffith OW, Stuehr DJ. Nitric oxide synthases: properities and catalytic mechanism. Annu Rev Physiol 1995 57 : 707 36
8. Miscusi M. The role of constitutive nitric oxide synthase in pathogenesis of secondary lesion after spinal cord injury. Preliminary results. J Neurosurg Sci 2002 46 : 55 9
9. Sharma HS, Wiklund L, Badgaiyan RD, Mohanty S, Alm P. Intracerebral administration of neuronal nitric oxide synthase antiserum attenuates traumatic brain injury-induced blood-brain barrier permeability, brain edema formation, and sensory motor disturbances in the rat. Acta Neurochir Suppl 2006 96 : 288 94
10. Bizzoco E, Vannucchi MG, Faussone-Pellegrini MS. Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Exp Neurol 2007 204 : 252 9
11. Carroll RC, Zukin RS. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 2002 25 : 571 7
12. Yanase M, Sakou T, Fukuda T. Role of N-methyl-D-aspartate receptor in acute spinal cord injury. J Neurosurg 1995 83 : 884 8
13. Rameau GA, Chiu LY, Ziff EB. Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-Methyl-D-aspartate receptor. J Biol Chem 2004 279 : 14307 14
14. Shen M, Pak DT. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu Rev Physiol 2000 62 : 755 78
15. Kornau HC, Schenker LT, Kennedy MB, Seeburg PH. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 1995 269 : 1737 40
16. Niethammer M, Kim E, Sheng M. Interaction between the C-terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 1996 16 : 2157 63
17. Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 1999 274 : 27467 73
18. Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 1999 284 : 1845 8
19. Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, Tymianski M. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 2002 298 : 846 50
20. Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML, Courtney MJ. The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol 2005 168 : 117 26
21. 2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus. Neurosci Lett 2004 355 : 197 200
22. Black P, Markowitz RS, Damjanov I, Finkelstein SD, Kushner H, Gillespie J, Feldman M. Models of spinal cord injury: part 3. Dynamic load technique. Neurosurgery 1988 22 : 51 60
23. Diaz-Ruiz A, Rios C, Duarte I, Correa D, Guizar-Sahagun G, Grijalva I, Ibarra A. Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats. Neurosci Lett 1999 266 : 61 4
24. Wu X, Yoo S, Wrathall JR. Real-time quantitative PCR analysis of temporal-spatial alterations in gene expression after spinal cord contusion. J Neurochem 2005 93 : 943 52
25. Cheng C, Chen M, Shi S, Gao S, Niu S, Li X, Liu H, Qin Y, Shen A. Effect of peripheral axotomy on gene expression of NIDD in rat neural tissues. J Mol Neurosci 2007 32 : 199 206
26. Zhu B, Luo L, Wayne-Moore GR, Paty DW, Cynader MS. Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis. Am J Pathol 2003 162 : 1639 50
27. Fukaya M, Watanabe M. Improved immunohistochemical detection of postsynaptically located PSD-95/SAP90 protein family by protease section pretreatment: a study in the adult mouse brain. J Comp Neurol 2000 426 : 572 86
28. Liu XZ, Xu XM, Hu R, Du C, Zhang SX, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin MF, Hsu CY, Choi DW. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 1997 17 : 5395 406
29. Yong C, Arnold PM, Zoubine MN, Citron BA, Watanabe I, Berman NE, Festoff BW. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury. J Neurotrauma 1998 15 : 459 72
30. Springer JE, Azbill RD, Knapp PE. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med 1999 5 : 943 6
31. Citron BA, Arnold PM, Sebastian C, Qin F, Malladi S, Ameenuddin S, Landis ME, Festoff BW. Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlate with apoptotic cell death. Exp Neurol 2000 166 : 213 26
32. Gresle MM, Jarrott B, Jones NM, Callaway JK. Injury to axons and oligodendrocytes following endothelin-1-induced middle cerebral artery occlusion in conscious rats. Brain Res 2006 1110 : 13 22
33. 1- Syntrophin mediated by PDZ domains. Cell 1996 84 : 757 67
34. Gao S, Cheng C, Zhao J, Chen M, Li X, Shi S, Niu S, Qin J, Lu M, Shen A. Developmental regulation of PSD-95 and nNOS expression in lumbar spinal cord of rats. Neurochem Int 2007 doi 10.1016/j.neuint. 2007.08.009
35. Cho KO, Hunt CS, Kennedy MB. The rat brain postsynaptic density fraction contains a homolog of the drosophila disc-large tumor suppressor protein. Neuron 1992 9 : 929 42
36. Liu C, Jin A, Zhou C, Min S. Gene expression of two kinds of constitutive nitric oxide synthase in injured spinal cord tissue. Chin J Traumatol 2002 5 : 3 6
37. Liu C, Jin A, Zhou C, Chen B. Nitric oxide synthase gene expression in injured spinal cord tissue. Chin Med J (Engl) 2002 115 : 740 2
38. Diaz-Ruiz A, Ibarrab A, Perez-Severianoa F, Guizar-Sahagun G, Grijalva I, Rios C. Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats. Neurosci Lett 2002 319 : 129 32
39. Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 1998 21 : 727 39
40. Vaziri ND, Lee YS, Lin CY, Lin VW, Sindhu RK. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Brain Res 2004 995 : 76 83
41. Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 2001 24 : 107 29
42. Savinainen A, Garcia EP, Dorow D, Marshall J, Liu YF. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J Biol Chem 2001 276 : 11382 6
43. Wada S, Yone K, Ishidou Y, Nagamine T, Nakahara S, Niiyama T, Sakou T. Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist. J Neurosurg 1999 91 : 98 104
44. Zhu C, Wang X, Qiu L, Peeters-Scholte C, Hagberg H, Blomgren K. Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia. J Neurochem 2004 90 : 462 71
45. Marrs GS, Green SH, Dailey ME. Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nat Neurosci 2001 4 : 1006 13
46. Okabe S, Kim HD, Miwa A, Kuriu T, Okado H. Continual remodeling of postsynaptic density and its regulation by synaptic activity. Nat Neurosci 1999 2 : 804 11
47. Kim BG, Dai HN, McAtee M, Vicini S, Bregman BS. Remodeling of synaptic structures in the motor cortex following spinal cord injury. Exp Neurol 2006 198 : 401 15
48. Rutter AR, Stephenson FA. Coexpression of postsynaptic density-95 protein with NMDA receptors results in enhanced receptor expression together with a decreased sensitivity to 1-glutamate. J Neurochem 2000 75 : 2501 10
49. Tao YX, Huang YZ, Me L, Johns RA. Expression of PSD-95/SAP90 is critical for NMDA receptor-mediated thermal hyperalgesia in the spinal cord. Neuroscience 2000 98 : 201 6
50. Morin-Richaud C, Feldblum S, Privat A. Astrocytes and oligodendrocytes reactions after a total section of the rat spinal cord. Brain Res 1998 783 : 85 101
51. Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 2001 32 : 2149 54
52. McCracken E, Fowler JH, Dewar D, Morrison S, McCulloch J. Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist SPD 502. J Cereb Blood Flow Metab 2002 22 : 1090 7
53. Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ. Concentrations of glutamate released following SCI kill oligodendrocytes in the spinal cord. Exp Neurol 2004 187 : 329 36
54. Vannucchia MG, Bizzocoa E, Corsania L, Gianfriddob M, Pedatac F, Faussone-Pellegrinia MS. Relationships between neurons expressing neuronal nitric oxide synthase, degree of microglia activation and animal survival. A study in the rat cortex after transient ischemia. Brain Res 2006 1113 : 218 27
55. Streit WJ. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Rev 2005 48 : 234 9
56. Dougherty KD, Dreyfus CF, Black IB. Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiol Dis 2000 7 : 574 85