Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D

FEBS Journal

Volumn 272, Issue 14, 2005, Pages 3733-3742

  Welin, Martin ^a   Skovgaard, Tine ^b   Knecht, Wolfgang ^c,d   Zhu, Chunying ^b   Berenstein, Dvora ^b   Munch Petersen, Birgitte ^b   Piškur, Jure ^c,e   Eklund, Hans ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b ROSKILDE UNIVERSITY   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d ASTRAZENECA R AND D   (Sweden)

^e LUND UNIVERSITY   (Sweden)

Author keywords

Crystal structure; Feedback inhibition; Gene therapy; Pro drug activation

Indexed keywords

ASPARTIC ACID; DEOXYRIBONUCLEOSIDE KINASE; GLUTAMIC ACID; MUTANT PROTEIN; THYMIDINE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; FEEDBACK SYSTEM; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MUTATION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ASPARAGINE; ASPARTIC ACID; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; KINETICS; MODELS, MOLECULAR; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES;

DROSOPHILA MELANOGASTER;

EID: 22544476496     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04803.x     Document Type: Article

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