-
1
-
-
42449107428
-
-
The FDA's Critical Path Initiative: US Food & Drug Administration, Rockville, MD, USA. www.fda.gov/oc/initiatives/criticalpath •• Includes an important position statement by the FDA demonstrating the positive view that the FDA leadership holds of genomic approaches to drug discovery.
-
The FDA's Critical Path Initiative: US Food & Drug Administration, Rockville, MD, USA. www.fda.gov/oc/initiatives/criticalpath •• Includes an important position statement by the FDA demonstrating the positive view that the FDA leadership holds of genomic approaches to drug discovery.
-
-
-
-
2
-
-
42449137093
-
-
Bethesda, MD, USA
-
Biotechnology Entrez Genome Project: National Center for Biotechnology Information, Bethesda, MD, USA. www.ncbi.nlm.nih.gov/genomes/ leuks.cgi
-
Biotechnology Entrez Genome Project
-
-
-
3
-
-
35348928161
-
A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load
-
Dickinson H, Moritz K, Wintour EM, Walker DW, Kett MM: A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load. Am J Physiol - Renal Physiol (2007) 293(4):F1093-F1098.
-
(2007)
Am J Physiol - Renal Physiol
, vol.293
, Issue.4
-
-
Dickinson, H.1
Moritz, K.2
Wintour, E.M.3
Walker, D.W.4
Kett, M.M.5
-
4
-
-
33750953227
-
Whole-genome re-sequencing
-
• Provides an excellent background review of short-read sequencing technologies
-
Bentley DR: Whole-genome re-sequencing. Curr Opin Genet Dev (2006) 16(6):545-552. • Provides an excellent background review of short-read sequencing technologies.
-
(2006)
Curr Opin Genet Dev
, vol.16
, Issue.6
, pp. 545-552
-
-
Bentley, D.R.1
-
6
-
-
56149112104
-
Whole-genome sequencing and assembly with high-throughput, short-read technologies
-
Sundquist A, Ronaghi M, Tang H, Pevzner P, Batzoglou S: Whole-genome sequencing and assembly with high-throughput, short-read technologies. PLoS ONE (2007) 2(5):e484.
-
(2007)
PLoS ONE
, vol.2
, Issue.5
-
-
Sundquist, A.1
Ronaghi, M.2
Tang, H.3
Pevzner, P.4
Batzoglou, S.5
-
7
-
-
34548734299
-
Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing
-
Taylor KH, Kramer RS, Davis JW, Guo J, Duff DJ, Xu D, Caldwell CW, Shi H: Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Res (2007) 67(18):8511-8518.
-
(2007)
Cancer Res
, vol.67
, Issue.18
, pp. 8511-8518
-
-
Taylor, K.H.1
Kramer, R.S.2
Davis, J.W.3
Guo, J.4
Duff, D.J.5
Xu, D.6
Caldwell, C.W.7
Shi, H.8
-
8
-
-
37049001640
-
Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
-
Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JP: Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Cancer Res (2007) 67(23):11335-11343.
-
(2007)
Cancer Res
, vol.67
, Issue.23
, pp. 11335-11343
-
-
Shen, L.1
Kondo, Y.2
Ahmed, S.3
Boumber, Y.4
Konishi, K.5
Guo, Y.6
Chen, X.7
Vilaythong, J.N.8
Issa, J.P.9
-
9
-
-
42449099589
-
-
James Watson's personal genome sequence: Human Genome Sequencing Center, Houston, TX, USA. jimwatsonsequence.cshl.edu/
-
James Watson's personal genome sequence: Human Genome Sequencing Center, Houston, TX, USA. jimwatsonsequence.cshl.edu/
-
-
-
-
10
-
-
35648976118
-
The diploid genome sequence of an individual human
-
Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, Walenz BP, Axelrod N, Huang J, Kirkness EF, Denisov G, Lin Y et al: The diploid genome sequence of an individual human. PLoS Biol (2007) 5(10):e254.
-
(2007)
PLoS Biol
, vol.5
, Issue.10
-
-
Levy, S.1
Sutton, G.2
Ng, P.C.3
Feuk, L.4
Halpern, A.L.5
Walenz, B.P.6
Axelrod, N.7
Huang, J.8
Kirkness, E.F.9
Denisov, G.10
Lin, Y.11
-
11
-
-
38449109315
-
Breakthrough of the year. It's all about me
-
Kaiser J: Breakthrough of the year. It's all about me. Science (2007) 318(5858):1843.
-
(2007)
Science
, vol.318
, Issue.5858
, pp. 1843
-
-
Kaiser, J.1
-
12
-
-
38049130261
-
Letting the genome out of the bottle - Will we get our wish?
-
Hunter DJ, Khoury MJ, Drazen JM: Letting the genome out of the bottle - Will we get our wish? N Engl J Med (2008) 358(2):105-107.
-
(2008)
N Engl J Med
, vol.358
, Issue.2
, pp. 105-107
-
-
Hunter, D.J.1
Khoury, M.J.2
Drazen, J.M.3
-
13
-
-
35348983887
-
-
Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S et al: A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 449(7164):851-861. •• Provides a key publication which comprehensively characterizes the patterns of genetic variation in four human population samples.
-
Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S et al: A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 449(7164):851-861. •• Provides a key publication which comprehensively characterizes the patterns of genetic variation in four human population samples.
-
-
-
-
14
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Describes a landmark study in the field of human disease genetics. Patient collections for seven common diseases were scanned for common variants that predispose to disease susceptibility, ••
-
Bentley D, Brown MA, Cardon LR, Caulfield M, Clayton DG, Compston A, Craddock N, Deloukas P, Donnelly P, Farrall M, Gough SCL et al: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 447(7145):661-678. •• Describes a landmark study in the field of human disease genetics. Patient collections for seven common diseases were scanned for common variants that predispose to disease susceptibility.
-
(2007)
Nature
, vol.447
, Issue.7145
, pp. 661-678
-
-
Bentley, D.1
Brown, M.A.2
Cardon, L.R.3
Caulfield, M.4
Clayton, D.G.5
Compston, A.6
Craddock, N.7
Deloukas, P.8
Donnelly, P.9
Farrall, M.10
Gough, S.C.L.11
-
15
-
-
31544449191
-
Using linkage genome scans to improve power of association in genome scans
-
Roeder K, Bacanu SA, Wasserman L, Devlin B: Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet (2006) 78(2):243-252.
-
(2006)
Am J Hum Genet
, vol.78
, Issue.2
, pp. 243-252
-
-
Roeder, K.1
Bacanu, S.A.2
Wasserman, L.3
Devlin, B.4
-
16
-
-
33745279392
-
Evaluating and improving power in whole-genome association studies using fixed marker sets
-
• Provides an excellent evaluation of the potential pitfalls and benefits of fixed SNP marker panels for genome-wide association studies
-
Pe'er I, de Bakker PI, Maller J, Yelensky R, Altshuler D, Daly MJ: Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet (2006) 38(6): 663-667. • Provides an excellent evaluation of the potential pitfalls and benefits of fixed SNP marker panels for genome-wide association studies.
-
(2006)
Nat Genet
, vol.38
, Issue.6
, pp. 663-667
-
-
Pe'er, I.1
de Bakker, P.I.2
Maller, J.3
Yelensky, R.4
Altshuler, D.5
Daly, M.J.6
-
17
-
-
34547788766
-
Enriching the analysis of genomewide association studies with hierarchical modeling
-
Chen GK, Witte JS: Enriching the analysis of genomewide association studies with hierarchical modeling. Am J Hum Genet (2007) 81(2):397-404.
-
(2007)
Am J Hum Genet
, vol.81
, Issue.2
, pp. 397-404
-
-
Chen, G.K.1
Witte, J.S.2
-
18
-
-
36249029788
-
Pathway-based approaches for analysis of genomewide association studies
-
Wang K, Li M, Bucan M: Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet (2007) 81(6):1278-1283.
-
(2007)
Am J Hum Genet
, vol.81
, Issue.6
, pp. 1278-1283
-
-
Wang, K.1
Li, M.2
Bucan, M.3
-
19
-
-
34347338690
-
-
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H et al: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 39(7):830-832.
-
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H et al: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 39(7):830-832.
-
-
-
-
20
-
-
33947719279
-
Potential therapeutic applications of autophagy
-
Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ: Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 6(4):304-312.
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.4
, pp. 304-312
-
-
Rubinsztein, D.C.1
Gestwicki, J.E.2
Murphy, L.O.3
Klionsky, D.J.4
-
21
-
-
35148878237
-
Drug discovery and computational evolutionary analysis
-
Provides a drug discovery-centric view of Darwinian selection analysis, •
-
Holbrook JD, Sanseau P: Drug discovery and computational evolutionary analysis. Drug Disc Today (2007) 12(19-20):826-832. • Provides a drug discovery-centric view of Darwinian selection analysis.
-
(2007)
Drug Disc Today
, vol.12
, Issue.19-20
, pp. 826-832
-
-
Holbrook, J.D.1
Sanseau, P.2
-
22
-
-
85152974579
-
-
Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF et al: Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 449(7164):913-918. •• Describes a study that demonstrates the power of the HapMap as a research dataset. Taking information on variation in four study populations, signatures of Darwinian selection were successfully detected.
-
Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF et al: Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 449(7164):913-918. •• Describes a study that demonstrates the power of the HapMap as a research dataset. Taking information on variation in four study populations, signatures of Darwinian selection were successfully detected.
-
-
-
-
23
-
-
35848933704
-
Adaptive evolution of genes underlying schizophrenia
-
Crespi B, Summers K, Dorus S: Adaptive evolution of genes underlying schizophrenia. Proc Biol Sci (2007) 274(1627):2801-2810.
-
(2007)
Proc Biol Sci
, vol.274
, Issue.1627
, pp. 2801-2810
-
-
Crespi, B.1
Summers, K.2
Dorus, S.3
-
25
-
-
42449121060
-
-
The Jackson Laboratory, Bar Harbor, ME, USA
-
Mouse Genome Informatics: The Jackson Laboratory, Bar Harbor, ME, USA (2008). www.informatics.jax.org
-
(2008)
-
-
-
26
-
-
34347391035
-
Utilizing RNA interference to enhance cancer drug discovery
-
Iorns E, Lord CJ, Turner N, Ashworth A: Utilizing RNA interference to enhance cancer drug discovery. Nat Rev Drug Discov (2007) 6(7):556-568.
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.7
, pp. 556-568
-
-
Iorns, E.1
Lord, C.J.2
Turner, N.3
Ashworth, A.4
-
27
-
-
32144452103
-
Lentiviral delivery of RNAi in hippocampal neurons
-
Janas J, Skowronski J, Van Aelst L: Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol (2006) 406:593-605.
-
(2006)
Methods Enzymol
, vol.406
, pp. 593-605
-
-
Janas, J.1
Skowronski, J.2
Van Aelst, L.3
-
28
-
-
40749091246
-
An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity
-
Klinghoffer RA, Roberts B, Annis J, Frazier J, Lewis P, Linsley PS, Cleary MA: An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity. Assay Drug Dev Technologies (2008) 6(1):105-119.
-
(2008)
Assay Drug Dev Technologies
, vol.6
, Issue.1
, pp. 105-119
-
-
Klinghoffer, R.A.1
Roberts, B.2
Annis, J.3
Frazier, J.4
Lewis, P.5
Linsley, P.S.6
Cleary, M.A.7
-
29
-
-
0037177625
-
Genetic dissection of transcriptional regulation in budding yeast
-
Brem RB, Yvert G, Clinton R, Kruglyak L: Genetic dissection of transcriptional regulation in budding yeast. Science (2002) 296(5568):752-755.
-
(2002)
Science
, vol.296
, Issue.5568
, pp. 752-755
-
-
Brem, R.B.1
Yvert, G.2
Clinton, R.3
Kruglyak, L.4
-
30
-
-
20144386111
-
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
-
Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin NE, Langston MA, Threadgill DW et al: Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet (2005) 37(3):233-242.
-
(2005)
Nat Genet
, vol.37
, Issue.3
, pp. 233-242
-
-
Chesler, E.J.1
Lu, L.2
Shou, S.3
Qu, Y.4
Gu, J.5
Wang, J.6
Hsu, H.C.7
Mountz, J.D.8
Baldwin, N.E.9
Langston, M.A.10
Threadgill, D.W.11
-
31
-
-
34548805282
-
A genome-wide association study of global gene expression
-
•• Describes an excellent study of the impact of variation on gene expression in lymphoblast cell lines. All the data in the study are available to download and analyze using a stand-alone tool
-
Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KC, Taylor J, Burnett E, Gut I, Farrall M, Lathrop GM et al: A genome-wide association study of global gene expression. Nat Genet (2007) 39(10):1202-1207. •• Describes an excellent study of the impact of variation on gene expression in lymphoblast cell lines. All the data in the study are available to download and analyze using a stand-alone tool.
-
(2007)
Nat Genet
, vol.39
, Issue.10
, pp. 1202-1207
-
-
Dixon, A.L.1
Liang, L.2
Moffatt, M.F.3
Chen, W.4
Heath, S.5
Wong, K.C.6
Taylor, J.7
Burnett, E.8
Gut, I.9
Farrall, M.10
Lathrop, G.M.11
-
32
-
-
34548738566
-
Population genomics of human gene expression
-
Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S et al: Population genomics of human gene expression. Nat Genet (2007) 39(10):1217-1224.
-
(2007)
Nat Genet
, vol.39
, Issue.10
, pp. 1217-1224
-
-
Stranger, B.E.1
Nica, A.C.2
Forrest, M.S.3
Dimas, A.4
Bird, C.P.5
Beazley, C.6
Ingle, C.E.7
Dunning, M.8
Flicek, P.9
Koller, D.10
Montgomery, S.11
-
33
-
-
36549053104
-
A survey of genetic human cortical gene expression
-
Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL et al: A survey of genetic human cortical gene expression. Nat Genet (2007) 39(12):1494-1499.
-
(2007)
Nat Genet
, vol.39
, Issue.12
, pp. 1494-1499
-
-
Myers, A.J.1
Gibbs, J.R.2
Webster, J.A.3
Rohrer, K.4
Zhao, A.5
Marlowe, L.6
Kaleem, M.7
Leung, D.8
Bryden, L.9
Nath, P.10
Zismann, V.L.11
-
34
-
-
34247579326
-
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
-
Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B et al: Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 3(4):e58.
-
(2007)
PLoS Genet
, vol.3
, Issue.4
-
-
Libioulle, C.1
Louis, E.2
Hansoul, S.3
Sandor, C.4
Farnir, F.5
Franchimont, D.6
Vermeire, S.7
Dewit, O.8
de Vos, M.9
Dixon, A.10
Demarche, B.11
-
35
-
-
38649137338
-
Sequence polymorphisms cause many false cis eQTLs
-
Alberts R, Terpstra P, Li Y, Breitling R, Nap JP, Jansen RC: Sequence polymorphisms cause many false cis eQTLs. PLoS ONE (2007) 2(7):e622.
-
(2007)
PLoS ONE
, vol.2
, Issue.7
-
-
Alberts, R.1
Terpstra, P.2
Li, Y.3
Breitling, R.4
Nap, J.P.5
Jansen, R.C.6
-
36
-
-
34548427938
-
Moving toward a system genetics view of disease
-
Sieberts SK, Schadt EE: Moving toward a system genetics view of disease. Mamm Genome (2007) 18(6-7):389-401.
-
(2007)
Mamm Genome
, vol.18
, Issue.6-7
, pp. 389-401
-
-
Sieberts, S.K.1
Schadt, E.E.2
-
37
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD, Venkatesan N, Finn R, Yang G, Rahmeh M, Untch M, Rusnak DW, Spehar G, Mullin RJ, Keith BR et al: Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res (2006) 66(3):1630-1639.
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
Finn, R.4
Yang, G.5
Rahmeh, M.6
Untch, M.7
Rusnak, D.W.8
Spehar, G.9
Mullin, R.J.10
Keith, B.R.11
-
38
-
-
34548385836
-
Translating pharmacogenomics: Challenges on the road to the clinic
-
Swen JJ, Huizinga TW, Gelderblom H, de Vries EG, Assendelft WJ, Kirchheiner J, Guchelaar HJ: Translating pharmacogenomics: Challenges on the road to the clinic. PLoS Med (2007) 4(8):e209.
-
(2007)
PLoS Med
, vol.4
, Issue.8
-
-
Swen, J.J.1
Huizinga, T.W.2
Gelderblom, H.3
de Vries, E.G.4
Assendelft, W.J.5
Kirchheiner, J.6
Guchelaar, H.J.7
-
39
-
-
33645082244
-
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
-
Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF et al: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenetics Genomics (2006) 16(4):297-306.
-
(2006)
Pharmacogenetics Genomics
, vol.16
, Issue.4
, pp. 297-306
-
-
Hung, S.I.1
Chung, W.H.2
Jee, S.H.3
Chen, W.C.4
Chang, Y.T.5
Lee, W.R.6
Hu, S.L.7
Wu, M.T.8
Chen, G.S.9
Wong, T.W.10
Hsiao, P.F.11
-
40
-
-
39649084919
-
The FDA Critical Path Initiative and its influence on new drug development
-
Provides a review of the FDA Critical Path Initiative and also highlights some of the progress to date toward achieving the goals of the Initiative, ••
-
Woodcock J, Woosley R: The FDA Critical Path Initiative and its influence on new drug development. Annu Rev Med (2008) 59: 1-12. •• Provides a review of the FDA Critical Path Initiative and also highlights some of the progress to date toward achieving the goals of the Initiative.
-
(2008)
Annu Rev Med
, vol.59
, pp. 1-12
-
-
Woodcock, J.1
Woosley, R.2
|