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Volumn 10, Issue 2, 2008, Pages 195-203

Studies towards the synthesis of methionine aminopeptidase inhibitors: Diversification utilizing a ROMP-derived coupling reagent

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; METHIONYL AMINOPEPTIDASE; PROTEINASE INHIBITOR;

EID: 42449141546     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc7000869     Document Type: Article
Times cited : (15)

References (49)
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    • Although considerable improvements have been made in this area in recent years (e.g, FTIR, MALDI-MS, Gelphase, and MAS NMR, etc, these techniques still do not provide analysis comparable to that of conventional solution-phase techniques e.g, TLC, GC-MS, LC-MS, SFC-MS, NMR, etc
    • Although considerable improvements have been made in this area in recent years (e.g., FTIR, MALDI-MS, Gelphase, and MAS NMR, etc.), these techniques still do not provide analysis comparable to that of conventional solution-phase techniques (e.g., TLC, GC-MS, LC-MS, SFC-MS, NMR, etc.).
  • 11
    • 0542421518 scopus 로고    scopus 로고
    • For references on monitoring solid-phase reactions, see
    • (a) For references on monitoring solid-phase reactions, see: Bing, Y. Acc. Chem. Res. 1998, 31, 621-630.
    • (1998) Acc. Chem. Res , vol.31 , pp. 621-630
    • Bing, Y.1
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    • 0037835827 scopus 로고    scopus 로고
    • (b) Zhang, W. Tetrahedron 2003, 59, 4475-4489.
    • (2003) Tetrahedron , vol.59 , pp. 4475-4489
    • Zhang, W.1
  • 30
    • 4544219680 scopus 로고    scopus 로고
    • Metathesis Polymerization: A Versatile Tool for the Synthesis of Surface-Functionalized Supports and Monolithic Materials
    • Grubbs, R. H, Ed, Wiley-VCH: Weinheim, Germany
    • (c) Buchmeiser, M. R. Metathesis Polymerization: A Versatile Tool for the Synthesis of Surface-Functionalized Supports and Monolithic Materials. In Handbook of Metathesis; Grubbs, R. H., Ed.; Wiley-VCH: Weinheim, Germany, 2003; Vol. 3, pp 226-254.
    • (2003) Handbook of Metathesis , vol.3 , pp. 226-254
    • Buchmeiser, M.R.1
  • 37
    • 42449135665 scopus 로고    scopus 로고
    • 2GOACC., implies that the oligomers were prepared by ROM polymerization using the second generation Grubbs catalyst and could be of varying length including n = 50, 75, or 100.
    • 2GOACC., implies that the oligomers were prepared by ROM polymerization using the second generation Grubbs catalyst and could be of varying length including n = 50, 75, or 100.
  • 40
    • 0033581550 scopus 로고    scopus 로고
    • While various protocols to remove the excess boronic acids with scavengers were attempted, none of these methods gave us significantly cleaner products. While most of the boronic acid could be scavenged by treatment with aqueous NaOH, as evident by TLC, NMR indicated unreacted boronic anhydride was present necessitating the use of high-throughput chromatographic purification, a For use of a polystryene diethanolamine-derived scavenger, see: Hall, D. G, Tailor, J, Gravel, M. Angew. Chem, Int. Ed. 1999, 38, 3064-3067
    • While various protocols to remove the excess boronic acids with scavengers were attempted, none of these methods gave us significantly cleaner products. While most of the boronic acid could be scavenged by treatment with aqueous NaOH, as evident by TLC, NMR indicated unreacted boronic anhydride was present necessitating the use of high-throughput chromatographic purification, (a) For use of a polystryene diethanolamine-derived scavenger, see: Hall, D. G.; Tailor, J.; Gravel, M. Angew. Chem., Int. Ed. 1999, 38, 3064-3067.
  • 41
    • 0038362703 scopus 로고    scopus 로고
    • 2, see: Molander, G. A.; Biolatto, B. J. Org. Chem. 2003, 68, 4302-4314.
    • 2, see: Molander, G. A.; Biolatto, B. J. Org. Chem. 2003, 68, 4302-4314.
  • 46
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    • The Tripos Associates: St. Louis, MO
    • SYBYL 6.9.2; The Tripos Associates: St. Louis, MO, 2004.
    • (2004) SYBYL 6.9.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.