Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBP 2-deficient hematopoietic cells

Blood

Volumn 111, Issue 6, 2008, Pages 2999-3004

  Akagi, Tadayuki ^a,c   Saitoh, Takayuki ^a   O'Kelly, James ^a   Akira, Shizuo ^b   Gombart, Adrian F ^a   Koeffler, H Phillip ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STAT3 PROTEIN; FLUOROURACIL; MEMBRANE ANTIGEN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RESPONSE; GENE EXPRESSION; GRANULOPOIESIS; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; LEUKOCYTE DIFFERENTIAL COUNT; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL LINEAGE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIESIS; IMMUNOLOGY; LEUKOCYTE; METABOLISM; MOUSE MUTANT;

ANIMALS; ANTIGENS, SURFACE; APOPTOSIS; BONE MARROW CELLS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINEAGE; CYTOKINES; FLUOROURACIL; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; LEUKOCYTES; MICE; MICE, KNOCKOUT; RNA, MESSENGER;

EID: 42449099998     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-04-087213     Document Type: Article

References (37)

1. Ramji DP, Foka P. CGAAT/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002;365:561-575.
2. McKnight SL. McBindall: a better name for CCAAT/enhancer binding proteins? Cell. 2001;107:259-261.
3. Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene. 2002;21:3377-3390.
4. Lekstrom-Himes JA. The role of C/EBP(epsilon) in the terminal stages of granulocyte differentiation. Stem Cells. 2001;19:125-133.
5. Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A. 1997;94:569-574.
6. Heath V, Suh HC, Holman M, et al. C/EBP deficiency results in hyperproliteration of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood. 2004; 104:1639-1647.
7. Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor G/EBP alpha. Immunity. 2004;21:853-863.
8. PabstT, Mueller BU, Zhang P, et al. Dominantnegative mutations of CEBPA. encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27:263-270.
9. Gombart AF, Hofmann WK, Kawano S, et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood. 2002;99:1332-1340.
10. Yamanaka R, Barlow C, Lekstrom-Himes J. et al. Impaired granulopoiesis, myelodysplasia, and early lethality in GGAAT/enhancer binding protein epsilon-deficient mice. Proc Natl Acad Sci U S A. 1997;94:13187-13192.
11. TanakaT, Akira S, Yoshida K. et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell. 1995;80:353-361.
12. Pizarro-Cerda J, Desjardins M, Moreno E, Akira S, Gorvel JP. Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection. J Immunol. 1999;162:3519-3526.
13. Screpanti I, Romani L, Musiani P, et al. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J. 1995;14:1932-1941.
14. Chen X, Liu W. Ambrosino C, et al. Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBPbeta. Blood. 1997;90:156-164.
15. Sterneck E, Tessarollo L, Johnson PR An essential role for C/EBPbeta in female reproduction. Genes Dev. 1997;11:2153-2162.
16. Matsusaka T Fujikawa K, NishioY, et al. Transcription factors N F-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A. 1993;90:10193-10197.
17. Brenner S, Prosch S, Schenke-Layland K, Riese U. Gausmann U, Platzer C. cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer- binding protein expression and monocytic differentiation. J Biol Chem. 2003;278:5597-5604.
18. Gorgoni B, Maritano D, Marthyn P, Righi M, Poli V. C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages. J Immunol. 2002;168:4055-4062.
19. Pope RM, Leutz A, Ness SA. C/EBP beta regulation of the tumor necrosis factor alpha gene. J Clin Invest. 1994;94:1449-1455.
20. Dunn SM, Coles LS, Lang RK, Gerondakis S, Vadas MA, Shannon MF Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colonystimulating factor promoter. Blood. 1994;83:2469-2479.
21. Bradley MN, Zhou L Smale ST. C/EBPbeta regulation in lipopolysaccharide- stimulated macrophages. Mol Cell Biol. 2003;23:4841-4858.
22. Bainton DF, Ullyot JL, Farquhar MG. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med. 1971;134:907-934.
23. Bjerregaard MD, Jurlander J, Klausen P Borregaard N. Cowland JB. The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow. Blood. 2003;101:4322-4332.
24. Natsuka S, Akira S, Nishio Y et al. Macrophage differentiation-specific expression of N F-IL6. a transcription factor for interleukin-6. Blood. 1992;79:460-466.
25. Scott LM, Civin CI, Rorth P, Friedman AD. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood. 1992:80:1725-1735.
26. Duprez E, Wagner K, Koch H, Tenen DG. C/EBP-beta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J. 2003;22:5806-5816.
27. Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP. Elevated levels of connective tissue growth factor WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res. 2001;61:8917-8923.
28. O'Kelly J, Hisatake J, HisatakeY Bishop J, Norman A, Koeffler HP. Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice. J Clin Invest. 2002;109:1091-1099.
29. Scheel-Toellner D, Wang KQ, Webb PR, et al. Early events in spontaneous neutrophil apoptosis. Biochem Soc Trans. 2004;32:461-464.
30. Edwards SW, Derouet M, Howse M, Moots RJ. Regulation of neutrophil apoptosis by Mcl-1. Biochem Soc Trans. 2004;32:489-492.
31. Hirai H, Zhang P, DayaramT et al. C/EBPbeta is required for "emergency" granulopoiesis. Nat Immunol. 2006:7:732-739.
32. Panopoulos AD, Zhang L, Snow JW, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 2006;108: 3682-3690.
33. Tang X, Metzger D, Leeman S, Amar S. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A. 2006;103:13777-13782.
34. Zhu S, Yoon K, Sterneck E, Johnson PF, Smart RC. CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin turnorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A. 2002;99:207-212.
35. Buck M, Poli V, Hunter T, Chojkier M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell. 2001;8:807-816.
36. Wessells J, Yakar S, Johnson PF. Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells. Mol Cell Biol. 2004;24:3238-3250.
37. Vegesna V Takeuchi S, Hofmann WK, et al. C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies. Leuk Res. 2002;26:451-457.