Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBPβ

Blood

Volumn 90, Issue 1, 1997, Pages 156-164

  Chen, Xueni ^b   Liu, Weimin ^b   Ambrosino, Concetta ^b   Ruocco, Maria R ^b   Poli, Valeria ^b   Romani, Luigina ^b   Quinto, Ileana ^b   Barbieri, Susan ^b   Holmes, Kevin L ^b   Venuta, Salvatore ^b   Scala, Giuseppe ^a  

^a Dipto Biochim Biotecnologie M   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOBLAST; B LYMPHOCYTE DIFFERENTIATION; CELL SPECIFICITY; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMORAL IMMUNE DEFICIENCY; IMMUNOREGULATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; B-LYMPHOCYTES; BONE MARROW; CCAAT-ENHANCER-BINDING PROTEINS; CELL COUNT; CELLS, CULTURED; DNA-BINDING PROTEINS; FLOW CYTOMETRY; INTERLEUKIN-7; MICE; MICE, MUTANT STRAINS; NUCLEAR PROTEINS;

EID: 0030917937     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Isshik H, Akira S, Tanabe O, Nakajima T, Shimamoto T, Hirano T, Kishimoto T: Constitutive and IL-1 inducible factors interact with the IL-1 responsive element in the IL-6 gene. Mol Cell Biol 10:2757, 1990
2. Zhang Y, Ron WN: Regulation of the interleukin-1β (IL-1β) gene by mycobacterial components and lipopolysaccharide mediated by two nuclear factor-IL-6 motifs. Mol Cell Biol 13:3831, 1993
3. Ramji DP, Vitelli A, Tronche F, Cortese R, Ciliberto G: The two C/EBP isoforms, IL-6 DBP/NF-IL6 and C/EBPδ/NF-IL6β, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res 21:289, 1993
4. Chang C, Chen T, Lei H, Chen D, Lee S: Molecular cloning of a transcription factor, AGP/EBP that belong to members of the C/EBP family. Mol Cell Biol 10:6642, 1990
5. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibler U: LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev 4:1541, 1990
6. Poli V, Mancini FP, Cortese R: IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643, 1990
7. Akira S, Kishimoto T: IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 127:25, 1992
8. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T: A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9:1897, 1990
9. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T: Macrophage differentiation specific expression of NF-IL6, a transcription factor for IL-6. Blood 79:460, 1992
10. Scott LM, Civin CI, Rorth P, Friedman AD: A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725, 1992
11. Cooper C, Johnson D, Roman C, Avitahl N, Tucker P, Calame K: The C/EBP family of transcriptional activators is functionally important for Ig VH promoter activity in vivo and in vitro. J Immunol 149:3225, 1992
12. Ron D, Habener JF: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6:439, 1992
13. Williams SC, Cantwell CA, Johnson PF: A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 5:1553, 1991
14. Kinoshita S, Akira S, Kishimoto T: A member of the C/ EBP family, NF-IL6/β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci USA 89:1473, 1992
15. Cooper C, Johnson D, Roman C, Avithal N, Ticker P, Calame K: The C/EBP family of transcriptional activators is functionally important for Ig VH promoter activity in vivo and in vitro. J Immunol 149:3225, 1992
16. Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D, Sellitto C, Scarpa S, Bellavia D, Lattanzio G, Bistoni F, Frati L, Cortese R, Gulino A, Ciliberto G, Coslantini F, Poli V: Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice. EMBO J 14:1932, 1995
17. Ryan DH, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN: Cytokine regulation of early human lymphopoiesis. J Immunol 152:5250, 1994
18. Whitlock CA, Witte ON: Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci USA 79:3608, 1982
19. Griffiths SD, Goodhead DT, Marsden SJ, Wright EG, Krajewski S, Reed JC, Korsmeyer SJ, Greaves M: Interleukin-7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis. J Exp Med 179:1789, 1994
20. Holmes KL, Lantz LM, Lee JS, Bedigia HG, Taubenberger JK: Characterization of a new antigen expressed by B and myeloid lineage cells identified by the monoclonal antibody LIP-6. Cell Immunol 166:131, 1995
21. Willcocks J. L, Hales A, Page TH, Foxwell BMJ: The murine T cell line CT6 provides a novel bioassay for interleukin-7. Eur J Immunol 23:716, 1993
22. Dorshkind K, Johnson A, Collins L, Keller GM, Phillips RA: Generation of purified stromal cell culture that supports lymphoid and myeloid precursors. J Immunol Methods 89: 37, 1986
23. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biochemistry 162:156, 1987
24. Scala G, Ruocco MR, Ambrosino C, Mallardo M, Giordano V, Baldassarre F, Dragonetti E, Quinto I, Venuta S: The expression of interleukin 6 is induced by the human immunodeficiency virus 1 TAT protein. J Exp Med 179:961, 1994
25. Potocnik A, Nielsen PJ, Eichmann K: In vitro generation of lymphoid precursors from embryonic stem cells. EMBO J 13:5274, 1994
26. Christ M, McCartney-Francis NL, Kulkarni AB, Ward JM, Mizel DE, Mackall CL, Gress RE, Hines KL, Tian H, Karlsson S, Wahl SM: Immune dysregulation in TGF-β1-deficient mice. J Immunol 153:1936, 1994
27. Gorman CM, Moffat LF, Howard BH: Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044, 1982
28. Ruocco MR, Chen X, Ambrosino C, Dragonetti E, Liu W, Mallardo M, De Falco G, Palmieri C, Franzoso G, Quinto I, Venuta S, Scala G: Regulation of HIV-1 long terminal repeats by interaction of C/EBP (NF-IL6 and NF-kB/rel transcription factors. J Biol Chem 271:22479, 1996
29. Park Y, Osmond DG: Phenotype and proliferation of early B lymphocyte precursor cells in mouse bone marrow. J Exp Med 165:444, 1987
30. Funk PE, Varas A, Witte PL: Activity of stem cell factor and IL-7 in combination on normal bone marrow B lineage cells. J Immunol 150:748, 1993
31. Cushley W, Harnett MM: Cellular signalling mechanisms in B lymphocytes. Biochem J 292:313, 1993
32. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S: Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571, 1988
33. Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S: Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 170:333, 1989
34. Grabstein HH, Waldschmidt TJ, Finkelman FD, Hess BW, Alpert AR, Boiani NE, Namen AE, Morrissey PJ: Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med 178:257, 1993
35. Mukaida N, Mahe Y, Matsushima K: Cooperative interaction of NF-κB-and C/EBP-like factor binding elements in activating the interleukin-8 gene by proinflammatory cytokines. J Biol Chem 265:21128, 1990
36. Rolink A, Melchers F: Molecular and cellular origin of lymphocyte diversity. Cell 66:1081, 1991
37. Jelinek DF, Splawski JB, Lipsky PE: The roles of interleukin 2 and interferon-γ in human B cell activation, growth and differentiation. Eur J Immunol 16:925, 1986
38. Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW: Mitogen-and IL-4-regulated expression of germ line IgG 2b transcripts: Evidence for directed heavy chain class switching. Cell 53:177, 1988
39. Stavnezer J, Radcliffe G, Lin Y, Nietupski J, Berggren L, Sitia R, Severinson E: Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci USA 85:7704, 1988
40. Robb RJ, Rusk CM, Yodoi J, Greene WC: Interleukin 2 binding molecule distinct from the Tac protein: Analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci USA 84:2002, 1987
41. Jelinek DF, Lipsky PE: Inhibitory influence of IL-4 on human B cell responsiveness. J Immunol 141:164, 1988
42. Lorente LL, Mitjavila F, Crevon M, Galanaud P: Dual effects of interleukin 4 on antigen-activated human B cells: Induction of proliferation and inhibition of interleukin 2-dependent differentiation. Eur J Immunol 20:1887, 1990
43. Susan, BS: 1995. Disorders of the spleen, in Handin RB, Samuel EL, Stossel TT (eds): Blood: Principles and Practice. Philadelphia, PA, Lippincott, 1995, p 1359
44. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ: Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc Natl Acad Sci USA 90:9730,1993
45. Johnston JA, Bacon CM, Riedy MC, O'Shea JJ: Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J Leukoc Biol 60:441, 1996
46. Kishimoto T, Taga T, Akira S: Cytokine signal transduction. Cell 76:253, 1994
47. Miyake K, Underhill CB, Lesley J, Kincade PW: Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 172:69, 1990
48. Rolink A, Streb M, Nishikawa SI, Melchers F: The C-kit encoded tyrosine kinase regulates the proliferation of early pre-B cell. Eur J Immunol 21:2609, 1991
49. Landreth KS, Narayanan R, Dorshkind K: Insulin-like growth factor (IGF-1) regulates pro-B cell differentiation. Blood 80:1207, 1992
50. Nagasawa T, Kikutani H, Kishimoto T: Molecular cloning and structure of a pre-B-cell growth stimulating factor. Proc Natl Acad Sci USA 91:2305, 1995
51. Wakatsuki Y, Neurath MF, Max EE, Strober W: The B cell-specific transcription factor BSAP regulates B cell proliferation. J Exp Med 179:1099, 1994
52. Domen J, Lugt NMT, Acton D, Laird PW, Linders K, Berns A: Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J Exp Med 178:1665, 1993
53. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S: Phosphorylation at threonine-235 by a rasdependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 90:2207, 1993
54. Lin J, Migone T, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common STAT proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331, 1995
55. Freeden-Jeffry UV, Vieira P, Lucian LA, McNeil T, Burdach SG, Murray R: Lymphopenia in interleukin(IL)-7 gene-deleted mice identifies IL-7 as a non redundant cytokine. J Exp Med 181:1519, 1995
56. Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, Davison BL. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 180:1955, 1994
57. Di Santo JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K: Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. Proc Natl Acad Sci USA 92:377, 1995
58. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794, 1995
59. Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckeley RH, O'Shea JJ, Leonard JW: Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development. Science 270:797, 1995
60. Nosaka T, van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMicckle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science 270:800, 1995
61. Tanaka T, Akira S, Yoshid K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353, 1995