The role of C/EBPε in the terminal stages of granulocyte differentiation

Stem Cells

Volumn 19, Issue 2, 2001, Pages 125-133

  Lekstrom Himes, Julie A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Granulopoiesis; Hematopoiesis; Myelopoiesis; Neutrophil; Transcription

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN;

ADIPOCYTE; ANIMAL TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; FETUS; GRANULOCYTE; GRANULOPOIESIS; LIVER CELL; MOUSE; NEUTROPENIA; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN ISOLATION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0035102650     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.19-2-125     Document Type: Review

References (64)

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3. CCAAT/ enhancer binding proteins are critical components of the transcriptional regulation of hematopoiesis
4. The fusion gene Cbfb-MYH 11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia
5. AML-1, the target of multiple chromosomal translocations in human leukemia, is essential for normal murine fetal hematopoiesis
6. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
7. Absence of fetal liver hematopoiesis in mice deficient in the transcriptional coactivator core binding protein b
8. Hematopoiesis in the fetal liver is impaired by the targeted mutagenesis of the gene encoding a non-DNA binding subunit of the transcription factor, PEBP2/CBF
9. The CBFβ subunit is essential for CBFα2 (AML 1) function in vivo
10. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
11. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
12. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
13. C/EBP, c-Myb, and PU. 1 cooperate to regulate the neutrophil elastase promoter
14. Regulation of the myeloperoxidase enhancer binding proteins PU.1, C/EBPα, β, and δ during granulocyte-lineage specification
15. A functional c-Myb gene is required for normal murine fetal hepatic hematopoiesis
16. Only late, nonmitotic stages of granulocyte differentiation in 32Dc13 cells are blocked by ectopic expression of murine c-Myb and its truncated forms
17. Antisense oligonucleotides from the stage-specific myeloid zinc finger MZF-1 inhibit granulopoiesis in vitro
18. Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1
19. Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent
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21. Human CCAAT displacement protein is homologous to Drosophila homeoprotein, cut
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23. CCAAT displacement protein (CDP/cut) recognizes a silencer element within the lactoferrin gene promoter
24. Isolation and characterization of the cDNA for mouse neutrophil collagenase: Demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression
25. Mice beating targeted interruptions of the homeobox gene hoxa9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
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33. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite
34. Inhibition of CCAAT/enhancer-binding protein α and β translation by upstream open reading frames
35. Translational control of C/EBPα and C/EBPβ isoform expression
36. Impaired energy homeostasis in C/EBP alpha knockout mice
37. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha
38. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
39. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis
40. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro
41. A novel human CCAAT/enhancer binding protein gene, C/EBPε, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus
42. Cloning of the novel human myeloid-cell-specific C/EBP-ε transcription factor
43. CCAAT/enhancer binding protein ε is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing
44. Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein ε
45. C/EBPε directly interacts with the DNA binding domain of c-Myb and cooperatively activates transcription of myeloid promoters
46. Myeloid transcription factor C/EBP epsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils
47. C/EBPε is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes
48. A short conserved motif is required for repressor domain function in the myeloid-specific transcription factor CCAAT/enhancer-binding protein ε
49. Representational difference analysis using myeloid cells from C/EBPε deletional mice
50. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice
51. CCAAT/enhancer binding protein ε is critical for effective neutrophil-mediated response to inflammatory challenge
52. The p47phox mouse knock-out model of chronic granulomatous disease
53. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
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55. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi Syndrome and "specifc" granule deficiency
56. Neutrophil-specific granule deficiency includes eosinophils
57. Absence of the largest platelet-von Willebrand multimers in a patient with lactoferrin deficiency and a bleeding tendency
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60. Neutrophil specific granule deficiency: Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor C/EBPε
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62. C/EBPα by-passes GCSF signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D c13 myeloblasts
63. A novel, myeloid transcription factor, C/EBPε, is upregulated during granulocytic, but not monocytic, differentiation
64. CCAAT/enhancer binding protein ε is a potiental retinoid target gene in acute promyelocytic leukemia treatment