Resting microglial motility is independent of synaptic plasticity in mammalian brain

Journal of Neurophysiology

Volumn 99, Issue 4, 2008, Pages 2026-2032

  Wu, Long Jun ^a   Zhuo, Min ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL MOTILITY; CHEMOTAXIS; CONFOCAL MICROSCOPY; ELECTROPHYSIOLOGY; FEMALE; LONG TERM POTENTIATION; MALE; MAMMAL; MICROGLIA; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; CELL MOVEMENT; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; LONG-TERM POTENTIATION; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; MICROSCOPY, CONFOCAL; NEURONAL PLASTICITY; RECEPTORS, CHEMOKINE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 42249105396     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01210.2007     Document Type: Article

References (36)

1. Beach TG, Woodhurst WB, MacDonald DB, Jones MW. Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 191: 27-30, 1995.
2. Bessis A, Bechade C, Bernard D, Roumier A. Microglial control of neuronal death and synaptic properties. Glia 55: 233-238, 2007.
3. Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39, 1993.
4. Bruce-Keller AJ. Microglial-neuronal interactions in synaptic damage and recovery. J Neurosci Res 58: 191-201, 1999.
5. Burnstock G. Historical review: ATP as a neurotransmitter. Trends Pharmacol Sci 27: 166-176, 2006.
6. Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8: 752-758, 2005.
7. Farber K, Kettenmann H. Physiology of microglial cells. Brain Res Brain Res Rev 48: 133-143, 2005.
8. Fields RD, Burnstock G. Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7: 423-436, 2006.
9. Gonzalez-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22: 219-240, 1999.
10. Gottlieb M, Matute C. Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia. J Cereb Blood Flow Metab 17: 290-300, 1997.
11. Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA. The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 99: 1263-1272, 2006.
12. Hagino Y, Kariura Y, Manago Y, Amano T, Wang B, Sekiguchi M, Nishikawa K, Aoki S, Wada K, Noda M. Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia. Glia 47: 68-77, 2004.
13. Hauss-Wegrzyniak B, Lynch MA, Vraniak PD, Wenk GL. Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses. Exp Neurol 176: 336-341, 2002.
14. Hickey WF. Basic principles of immunological surveillance of the normal central nervous system. Glia 36: 118-124, 2001.
15. Hughes PE, Alexi T, Walton M, Williams CE, Dragunow M, Clark RG, Gluckman PD. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Prog Neurobiol 57: 421-450, 1999.
16. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20: 4106-4114, 2000.
17. Kandel ER. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294: 1030-1038, 2001.
18. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312-318, 1996.
19. Kuhn SA, van Landeghem FK, Zacharias R, Farber K, Rappert A, Pavlovic S, Hoffmann A, Nolte C, Kettenmann H. Microglia express GABA(B) receptors to modulate interleukin release. Mol Cell Neurosci 25: 312-322, 2004.
20. Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69: 341-374, 2003.
21. Malenka RC, Bear MF. LTP and LTD: an embarrassment of riches. Neuron 44: 5-21, 2004.
22. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318, 2005.
23. Noda M, Nakanishi H, Nabekura J, Akaike N. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J Neurosci 20: 251-258, 2000.
24. Pang PT, Lu B. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Res Rev 3: 407-430, 2004.
25. Pankratov Y, Castro E, Miras-Portugal MT, Krishtal O. A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. Eur J Neurosci 10: 3898-3902, 1998.
26. Silva AJ. Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J Neurobiol 54: 224-237, 2003.
27. Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33: 256-266, 2001.
28. Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1: 14, 2004.
29. Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 28: 101-107, 2005.
30. Wang Q, Rowan MJ, Anwyl R. Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. J Neurosci 24: 6049-6056, 2004.
31. Wieraszko A. Facilitation of hippocampal potentials by suramin. J Neurochem 64: 1097-1101, 1995.
32. Wu LJ, Ko SW, Toyoda H, Zhao MG, Xu H, Vadakkan KI, Ren M, Knifed E, Shum F, Quan J, Zhang XH, Zhuo M. Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS ONE 2: e167, 2007a.
33. Wu LJ, Vadakkan KI, Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55: 810-821, 2007b.
34. Xiong H, Zeng YC, Zheng J, Thylin M, Gendelman HE. Soluble HIV-1 infected macrophage secretory products mediate blockade of long-term potentiation: a mechanism for cognitive dysfunction in HIV-1-associated dementia. J Neurovirol 5: 519-528, 1999.
35. Zhang X, Chen Y, Wang C, Huang LY. Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci USA 104: 9864-9869, 2007.
36. Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. J Neurosci 20: 542-549, 2000.