The regulatory T-cell phenotype in progressive mycosis fungoides

Giornale Italiano di Dermatologia e Venereologia

Volumn 143, Issue 1, 2008, Pages 15-19

  Hallermann, C ^a,d   Schulze, H J ^a   Neumann, C ^b   Klemke, C D ^c  

^a Department of Dermatology Fachklinik Hornheide ^*  (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Disease progression; Lymphoma, T cell, cutaneous; Mycosis fungoides; S zary syndrome

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA;

ANTIGEN EXPRESSION; CELL SIZE; CELL TRANSFORMATION; CUTANEOUS T CELL LYMPHOMA; DISEASE COURSE; FATALITY; HUMAN; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMA CELL; MYCOSIS FUNGOIDES; PHENOTYPE; REGULATORY T LYMPHOCYTE; REVIEW; T CELL LEUKEMIA;

EID: 42249095061     PISSN: 03920488     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005;105:3768-85.
2. Klemke CD, Mansmann U, Poenitz N, Dippel E, Goerdt S. Prognostic factors and prediction of prognosis by the CTCL Severity Index in mycosis fungoides and Sézary syndrome. Br J Dermatol 2005;153:118-24.
3. Vergier B, de Muret A, Beylot-Barry M, Vaillant L, Ekouevi D, Chene G et al. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneious Lymphomas. Blood 2000;95:2212-8.
4. Vonderheid EC, Bernengo MG, Burg G, Duvic M, Heald P, Laroche L et al. Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol 2002;46:95-106.
5. Klemke CD, Dippel E, Dembinski A, Pönitz N, Assaf C, Hummel M et al. Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides. J Pathol 2002;197:348-54.
6. Salhany KE, Cousar JB, Greer JP, Casey TT, Fields JP, Collins RD. Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study. Am J Pathol 1988;132:265-77.
7. Greer JP, Salhany KE, Cousar JB, Fields JP, King LE, Graber SE et al. Clinical features associated with transformation of cerebriform T-cell lymphoma to a large cell process. Hematol Oncol. 1990;8:215-27.
8. Cerroni L, Rieger E, Hödl S, Kerl H. Clinicopathologic and immunologic features associated with transformation of mycosis fungoides to large-cell lymphoma. Am J Surg Pathol 1992;16:543-52.
9. Barberio E, Thomas L, Skowron F, Balme B, Dalle S. Transformed mycosis fungoides: clinicopathological features and outcome. Br J Dermatol 2007;157:284-9.
10. Stefanato CM, Tallini G, Crotty PL. Histologic and immunophenotypic features prior to transformation in patients with transformed cutaneous T-cell lymphoma: is CD25 expression in skin biopsy samples predictive of large cell transformation in cutaneous T-cell lymphoma? Am J Dermatopathol 1998;20:1-6.
11. Hallermann C, Kaune KM, Gesk S, Martin-Subero JI, Gunawan B, Griesinger F et al. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. J Invest Dermatol 2004;123:213-9.
12. Prochazkova M, Chevret E, Beylot-Barry M, Vergier B, Sobotka J, Merlio JP. Large cell transformation of mycosis fungoides: tetraploidization within skin tumor large cells. Cancer Genet Cytogenet 2005;163:1-6.
13. Prochazkova M, Chevret E, Mainhaguiet G, Sobotka J, Vergier B, Belaud-Rotureau MA et al. Common chromosomal abnormalities in mycosis fungoides transformation. Genes Chromosomes Cancer 2007;46:828-38.
14. Yawalkar N, Ferenczi K, Jones DA, Yamanaka K, Suh KY, Sadat S et al. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 2003;102:4059-66.
15. Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 2004;351:2159-69.
16. Hoppe RT, Medeiros LJ, Warnke RA, Wood GS. CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides. J Am Acad Dermatol 1995;32:448-53.
17. Vermeer MH, van Doorn R, Dukers D, Bekkenk MW, Meijer CJ, Willemze R. CD8+ T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas Ligand, and killing inhibitory receptors and their relationship with clinical behavior. J Clin Oncol 2001;19:4322-9.
18. Luftl M, Feng A, Licha E, Schuler G. Dendritic cells and apoptosis in mycosis fungoides. Br J Dermatol 2002;147:1171-9.
19. Gershon RK, Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes.Immunology. 1970;18:723-37.
20. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
21. Suri-Payer E, Amar AZ, Thornton AM, Shevach EM. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998;160:1212-8.
22. Sakaguchi S.Regulatory T cells: key controllers of immunologic self-tolerance.Cell. 2000;101:455-8.
23. Green DR, Flood PM, Gershon RK. Immunoregulatory T-cell pathways. Annu Rev Immunol 1983;1:439-63.
24. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001;27:68-73.
25. Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001;27:18-20.
26. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6.
27. Roncador G, Brown PJ, Maestre L, Hue S, Martinez-Torrecuadrada JL, Ling KL et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur 3 Immunol 2005;35:1681-91.
28. Wang J, Ioan-Facsinay A, van der Voort EI, Huizinga TW, Toes RE. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007;37:129-38.
29. Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. Trends Immunol 2006;27:541-4.
30. Fritzsching B, Oberle N, Eberhardt N, Quick S, Haas J, Wildemann B et al. In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol 2005;175:32-6.
31. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective. Eur J Immunol 2007;37(Suppl 1):S116-23.
32. Talpur R, Jones DM, Alencar AJ, Apisarnthanarax N, Herne KL, Yang Y et al. CD25 expression is correlated with histological grade and response to denileukin diftitox in cutaneous T-cell lymphoma. J Invest Dermatol 2006;126:575-83.
33. Shirono K, Hattori T, Hata H, Nishimura H, Takatsuki K. Profiles of expression of activated cell antigens on peripheral blood and lymph node cells from different clinical stages of adult T-cell leukemia. Blood 1989;73:1664-71.
34. Yano H, Ishida T, Inagaki A, Ishii T, Kusumoto S, Komatsu H et al. Regulatory T-cell function of adult T-cell leukemia/lymphoma cells. Int J Cancer 2007;120:2052-7.
35. Roncador G, Garcia JF, Garcia JF, Maestre L, Lucas E, Menarguez J et al. FOXP3, a selective marker for a subset of adult T-cell leukaemia/lyrnphoma. Leukemia 2005;19:2247-53.
36. Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J et al. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol 2004;126:81-4.
37. Berger CL, Tigelaar R, Cohen J, Mariwalla K, Trinh J, Wang N et al. Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. Blood 2005;105:1640-7.
38. Klemke CD, Fritzsching B, Franz B, Kleinmann EV, Oberle N, Poenitz N et al. Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas. Leukemia 2006;20:1123-9.
39. Hallermann C, Niermann C, Schulze HJ. Regulatory T-cell phenotype in association with large cell transformation of mycosis fungoides. Eur J Haematol 2007;78:260-3.
40. Banham AH, Brown PJ, Lyne L, Schulze HJ, Hallermann C. Is FOXP3 expressed in cutaneous T-cell lymphomas? Eur J Haematol 2008;80:90-1.
41. Gjerdrum LM, Woetmann A, Odum N, Burton CM, Rossen K, Skovgaard GL et al. FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. Leukemia 2007;21:2512-8.