HDAC activity is required for p65/RelA-dependent repression of PPARδ-mediated transactivation in human keratinocytes

Journal of Investigative Dermatology

Volumn 128, Issue 5, 2008, Pages 1095-1106

  Aarenstrup, Lene ^a   Flindt, Esben Noerregaard ^a   Otkjaer, Kristian ^b   Kirkegaard, Morten ^a   Andersen, Jens Skorstensgaard ^a   Kristiansen, Karsten ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN SUBUNIT; SYNAPTOTAGMIN I;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

EID: 42149102003     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701146     Document Type: Article

References (52)

1. Ashburner BP, Westerheide SD, Baldwin AS Jr (2001) The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21:7065-77
2. Birbach A, Gold P, Binder BR, Hofer E, Martin De R, Schmid JA (2002) Signaling molecules of the NF-κB pathway shuttle constitutively between cytoplasm and nucleus. J Biol Chem 277:10842-51
3. Blanchard F, Chipoy C (2005) Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases? Drug Discov Today 10:197-204
4. Burdick AD, Kim DJ, Peraza MA, Gonzales FJ, Peters JM (2006) The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation. Cell Signal 18:9-20
5. Carlotti F, Dower SK, Qwarnstrom EE (2000) Dynamic shuttling of nuclear factor κB between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J Biol Chem 275:41024-8
6. Cervoni N, Szyf M (2001) Demethylase activity is directed by histone acetylation. J Biol Chem 276:40778-87
7. Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ et al. (1999) Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J Biol Chem 274:32048-54
8. Dong X, Lutz W, Schroeder TM, Bachman LA, Westendorf JJ, Kumar R et al. (2005) Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter. Proc Natl Acad Sci USA 102:16007-12
9. Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril M-B et al. (2002) The retinoblastoma-histone deacetylase 3 complex inhibits PPARγ and adipocyte differentiation. Dev Cell 3:903-10
10. Fuks F, Burgers WA, Brehm A, Hughes-Daviea L, Kouzarides T (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24:88-91
11. Gao Z, He Q, Peng B, Chiao PJ, Ye J (2006) Regulation of nuclear translocation of HDAC2 by IκBα is required for tumor necrosis factor inhibition of peroxisome proliferators-activated receptor γ function. J Biol Chem 281:4540-7
12. Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R (1999) Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18:6888-95
13. Guenther MG, Barak O, Lazar MA (2001) The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 18:6091-101
14. Hansen JB, Petersen RK, Larsen BM, Bartkova J, Alsner J, Kristiansen K (1999) Activation of peroxisome proliferator-activated receptor bypasses the function of the retinoblastoma protein in adipocyte differentiation. J Biol Chem 274:2386-93
15. Hinata K, Gervin AM, Jennifer Zhang Y, Khavari PA (2003) Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skin. Oncogene 22:1955-64
16. Johansen C, Flindt E, Kragballe K, Henningsen J, Westergaard M, Kristiansen K et al. (2005) Inverse regulation of the nuclear factor-κB binding to the p53 and interleukin-8 κB response elements in lesional psoriatic skin. J Invest Dermatol 124:1284-92
17. 3 induced differentiation of cultured human keratinocytes is accompanied by a PKC-independent regulation of AP-1 DNA binding activity. J Invest Dermatol 114:1174-9
18. Jové M, Laguna JC, Vázquez-Carrera M (2005) Agonist-induced activation releases peroxisome proliferators-activated receptor β/δ from its inhibition by palmitate-induced nuclear factor-κB in skeletal muscle cells. Biochim Biophys Acta 1734:52-61
19. Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AGP et al. (2003) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA. Nat Immunol 5:104-12
20. Kim DJ, Bility MT, Billin AN, Willson TM, Gonzales FJ, Peters JM (2006) PPARα/δ selectively induces differentiation and inhibits cell proliferation. Cell Death Differ 13:53-60
21. Krämer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA et al. (2003) The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 22:3411-20
22. Kussmann-Gerber S, Kratchmarova I, Mandrup S, Kristiansen K (1999) Microaffinity columns for analysis of protein-protein interactions. Anal Biochem 271:102-5
23. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA (2001) Possible new role for NF-κB in the resolution of inflammation. Nat Med 7:1291-7
24. Li M, Pascual G, Glass CK (2000) Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol 20:4699-707
25. Lindemann RK, Gabrielli B, Johnstone RW (2004) Histone-deacetylase inhibitors for treatment of cancer. Cell Cycle 6:779-88
26. McLaughlin F, La Thangue NB (2004) Histone deacetylase inhibitors in psoriasis therapy. Curr Drug Targets Inflamm Allergy 3:213-9
27. Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J et al. (2001) Impaired skin wound healing in peroxisome proliferatoractivated receptor (PPAR) α and PPAR β mutant mice. J Cell Biol 154:799-814
28. Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (1999) HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J 15:5099-107
29. Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V et al. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437:759-63
30. Planavila A, Laguna JC, Vázquez-Carrera M (2005) Nuclear factor-kB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. J Biol Chem 280:17464-71
31. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82
32. Rivier M, Safonova I, Lebrun P, Griffiths CEM, Ailhaud G, Michel S (1998) Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-21
33. Ruan H, Pownall HJ, Lodish HF (2003) Troglitazone antagonizes tumor necrosis factor-α-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-κB. J Biol Chem 278:28181-92
34. Saunders N, Dicker A, Popa C, Jones S, Dahler A (1999) Histone deacetylase inhibitors as potential anti-skin cancer agents. Cancer Res 59:399-404
35. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S et al. (2004) Peroxisome proliferator-activated receptor (PPAR)-βδ stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-83
36. Seitz CS, Lin Q, Deng H, Khavari PA (1998) Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB. Proc Natl Acad Sci USA 95:2307-12
37. Smith CL, Hager GL (1997) Transcriptional regulation of mammalian genes in vivo: a tale of two templates. J Biol Chem 272:27493-6
38. Staels B, Koenig W, Habib A, Merval R, Lebret M, Torra IP et al. (1998) Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393:790-3
39. Stein B, Baldwin AS, Ballard DW, Greene WC, Angel P, Herrlich P (1993) Cross-coupling of the NF-kB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12:3879-91
40. Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH et al. (2000) 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway. Proc Natl Acad Sci USA 97:4844-9
41. Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA et al. (1999) A novel therapy for colitis utilizing PPARγ ligands to inhibit the epithelial inflammatory response. J Clin Invest 104:383-9
42. Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T et al. (2003) Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol 3:224-30
43. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T et al. (2005) Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducible expressing different PPAR isoforms. Nucl Recept 3:3
44. Takao J, Yudate T, Das A, Shikano S, Bonkobara M, Ariizumi K et al. (2003) Expression of NF-κB in epidermis and the relationship between NF-κB activation and inhibition of keratinocyte growth. Br J Dermatol 148:680-8
45. Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, Heim M et al. (2001) Critical roles of PPAR β/δ in keratinocyte response to inflammation. Genes Dev 15:3263-77
46. Targett-Adams P, McElwee MJ, Ehrenborg E, Gustafsson MC, Palmer CN, McLauchlan J (2005) A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein. Biochim Biophys Acta 1728:95-104
47. Viatour P, Legrand-Poels S, van Lint C, Warnier M, Merville M-P, Gielen J et al. (2003) Cytoplasmic IkBa increases NF-kB-independent transcription through binding to histone deacetylase (HDAC)1 and HDAC3. J Biol Chem 278:46541-8
48. Westergaard M, Henningsen J, Johansen C, Rasmussen S, Svendsen ML, Jensen UB et al. (2003) Expression and localization of peroxisome proliferator-activated receptors and nuclear factor κB in normal and lesional psoriatic skin. J Invest Dermatol 121:1104-17
49. Westergaard M, Henningsen J, Svendsen ML, Johansen C, Jensen UB, Schroder HD et al. (2001) Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-12
50. Xiao G, Harhaj EW, Sun S-C (2001) NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol Cell 7:401-9
51. Xiao S, Ghosh S (2005) NF-κB, an evolutionarily conserved mediator of immune and inflammatory responses. Adv Exp Med Biol 560:41-5
52. Zamir I, Zhang J, Lazar MA (1997) Stoichiometric and steric principles governing repression by nuclear hormone receptors. Genes Dev 11:835-46