Activin A: Autocrine regulator of kidney development and repair

Endocrine Journal

Volumn 55, Issue 1, 2008, Pages 1-9

  Maeshima, Akito ^a,b   Miya, Masaaki ^a   Mishima, Keiichiro ^a   Yamashita, Shin ^a   Kojima, Itaru ^a   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Activin; Follistatin; Kidney regeneration; Renal organogenesis

Indexed keywords

ACTIVIN A; ACTIVIN RECEPTOR 2; BONE MORPHOGENETIC PROTEIN; FOLLISTATIN; SMAD PROTEIN; ACTIVIN; ACTIVIN RECEPTOR;

AUTOCRINE EFFECT; CELL PROLIFERATION; ENDOCYTOSIS; GENE TARGETING; GLOMERULONEPHRITIS; HUMAN; KIDNEY CARCINOMA; KIDNEY DEVELOPMENT; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY ISCHEMIA; KIDNEY POLYCYSTIC DISEASE; KNOCKOUT MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; URETER; UROGENITAL TRACT MALFORMATION; ANIMAL; BIOLOGICAL MODEL; EMBRYONIC STRUCTURES; GENETICS; KIDNEY; ORGANOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT; REGENERATION;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; AUTOCRINE COMMUNICATION; FOLLISTATIN; HUMANS; KIDNEY; KIDNEY DISEASES; MODELS, BIOLOGICAL; ORGANOGENESIS; REGENERATION; URETER; WOLFFIAN DUCTS;

EID: 42049121477     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.KR-113     Document Type: Review

References (67)

1. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986) Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature 321: 779-782.
2. Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J (1986) Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321: 776-779.
3. Murata M, Eto Y, Shibai H, Sakai M, Muramatsu M (1988) Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc Natl Acad Sci USA 85: 2434-2438.
4. Schubert D, Kimura H, LaCorbiere M, Vaughan J, Karr D, Fischer WH (1990) Activin is a nerve cell survival molecule. Nature 344: 868-870.
5. Smith JC, Price BM, Van Nimmen K, Huylebroeck D (1990) Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 345: 729-731.
6. van den Eijnden-Van Raaij AJ, van Zoelent EJ, van Nimmen K, Koster CH, Snoek GT, Durston AJ, Huylebroeck D (1990) Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction. Nature 345: 732-734.
7. Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA (1990) Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63: 485-493.
8. Mashima H, Ohnishi H, Wakabayashi K, Mine T, Miyagawa J, Hanafusa T, Seno M, Yamada H, Kojima I (1996) Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest 97: 1647-1654.
9. Zhang YQ, Zhang H, Maeshima A, Kurihara H, Miyagawa J, Takeuchi T, Kojima I (2002) Up-regulation of the expression of activins in the pancreatic duct by reduction of the beta-cell mass. Endocrinology 143: 3540-3547.
10. Kogure K, Omata W, Kanzaki M, Zhang YQ, Yasuda H, Mine T, Kojima I (1995) A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Gastroenterology 108: 1136-1142.
11. Kogure K, Zhang YQ, Maeshima A, Suzuki K, Kuwano H, Kojima I (2000) The role of activin and transforming growth factor-beta in the regulation of organ mass in the rat liver. Hepatology 31: 916-921.
12. Maeshima K, Maeshima A, Hayashi Y, Kishi S, Kojima I (2004) Crucial role of activin a in tubulogenesis of endothelial cells induced by vascular endothelial growth factor. Endocrinology 145: 3739-3745.
13. Poulaki V, Mitsiades N, Kruse FE, Radetzky S, Iliaki E, Kirchhof B, Joussen AM (2004) Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression. Am J Pathol 164: 1293-1302.
14. Jones KL, de Kretser DM, Patella S, Phillips DJ (2004) Activin A and follistatin in systemic inflammation. Mol Cell Endocrinol 225: 119-125.
15. Ball EM, Risbridger GP (2001) Activins as regulators of branching morphogenesis. Dev Biol 238: 1-12.
16. Werner S, Alzheimer C (2006) Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev 17: 157-171.
17. Maeshima A, Nojima Y, Kojima I (2001) The role of the activin-follistatin system in the developmental and regeneration processes of the kidney. Cytokine Growth Factor Rev 12: 289-298.
18. Kojima I, Maeshima A, Zhang YQ (2001) Role of the activin-follistatin system in the morphogenesis and regeneration of the renal tubules. Mol Cell Endocrinol 180: 179-182.
19. G Ht, Neidhardt H, Schneider C, Pohl J (1995) Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. Biochem Biophys Res Commun 206: 608-613.
20. Oda S, Nishimatsu S, Murakami K, Ueno N (1995) Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus. Biochem Biophys Res Commun 210: 581-588.
21. Fang J, Yin W, Smiley E, Wang SQ, Bonadio J (1996) Molecular cloning of the mouse activin beta E subunit gene. Biochem Biophys Res Commun 228: 669-674.
22. Welt C, Sidis Y, Keutmann H, Schneyer A (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med (Maywood) 227: 724-752.
23. ten Dijke P, Hill CS (2004) New insights into TGF-beta-Smad signalling. Trends Biochem Sci 29: 265-273.
24. Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700.
25. Zhang L, Deng M, Parthasarathy R, Wang L, Mongan M, Molkentin JD, Zheng Y, Xia Y (2005) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Mol Cell Biol 25: 60-65.
26. Cocolakis E, Lemay S, Ali S, Lebrun JJ (2001) The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin. J Biol Chem 276: 18430-18436.
27. Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R (1987) Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone. Proc Natl Acad Sci USA 84: 8282-8286.
28. Shimonaka M, Inouye S, Shimasaki S, Ling N (1991) Follistatin binds to both activin and inhibin through the common subunit. Endocrinology 128: 3313-3315.
29. Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H (1990) Activin-binding protein from rat ovary is follistatin. Science 247: 836-838.
30. Nakamura T, Sugino K, Titani K, Sugino H (1991) Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. J Biol Chem 266: 19432-19437.
31. Hashimoto O, Nakamura T, Shoji H, Shimasaki S, Hayashi Y, Sugino H (1997) A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J Biol Chem 272: 13835-13842.
32. Mather JP (1996) Follistatins and alpha 2-macroglobulin are soluble binding proteins for inhibin and activin. Horm Res 45: 207-210.
33. Schneyer A, Tortoriello D, Sidis Y, Keutmann H, Matsuzaki T, Holmes W (2001) Follistatin-related protein (FSRP): a new member of the follistatin gene family. Mol Cell Endocrinol 180: 33-38.
34. Adkins HB, Bianco C, Schiffer SG, Rayhorn P, Zafari M, Cheung AE, Orozco O, Olson D, De Luca A, Chen LL, Miatkowski K, Benjamin C, Normanno N, Williams KP, Jarpe M, LePage D, Salomon D, Sanicola M (2003) Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J Clin Invest 112: 575-587.
35. Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C (1999) Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 401: 480-485.
36. Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (2004) Novel factors in regulation of activin signaling. Mol Cell Endocrinol 225: 1-8.
37. Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Ying SY (2006) Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp Biol Med (Maywood) 231: 534-544.
38. Saxén L: Organogenesis of the kidney, Cambridge; New York, Cambridge University PRess 1987.
39. Shah MM, Sampogna RV, Sakurai H, Bush KT, Nigam SK (2004) Branching morphogenesis and kidney disease. Development 131: 1449-1462.
40. Ichikawa I, Kuwayama F, Pope JCt, Stephens FD, Miyazaki Y (2002) Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT. Kidney Int 61: 889-898.
41. Pohl M, Bhatnagar V, Mendoza SA, Nigam SK (2002) Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int 61: 10-19.
42. Shakya R, Watanabe T, Costantini F (2005) The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. Dev Cell 8: 65-74.
43. Maeshima A, Vaughn DA, Choi Y, Nigam SK (2006) Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol 295: 473-485.
44. Ritvos O, Tuuri T, Eramaa M, Sainio K, Hilden K, Saxen L, Gilbert SF (1995) Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev 50: 229-245.
45. Maeshima A, Yamashita S, Maeshima K, Kojima I, Nojima Y (2003) Activin a produced by ureteric bud is a differentiation factor for metanephric mesenchyme. J Am Soc Nephrol 14: 1523-1534.
46. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK (2004) TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol 266: 285-298.
47. Chang H, Brown CW, Matzuk MM (2002) Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23: 787-823.
48. Maeshima A, Shiozaki S, Tajima T, Nakazato Y, Naruse T, Kojima I (2000) Number of glomeruli is increased in the kidney of transgenic mice expressing the truncated type II activin receptor. Biochem Biophys Res Commun 268: 445-449.
49. Montesano R, Schaller G, Orci L (1991) Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell 66: 697-711.
50. Montesano R, Matsumoto K, Nakamura T, Orci L (1991) Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67: 901-908.
51. Maeshima A, Zhang YQ, Furukawa M, Naruse T, Kojima I (2000) Hepatocyte growth factor induces branching tubulogenesis in MDCK cells by modulating the activin-follistatin system. Kidney Int 58: 1511-1522.
52. Bonventre JV, Weinberg JM (2003) Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14: 2199-2210.
53. Devarajan P (2006) Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 17: 1503-1520.
54. Maeshima A, Zhang YQ, Nojima Y, Naruse T, Kojima I (2001) Involvement of the activin-follistatin system in tubular regeneration after renal ischemia in rats. J Am Soc Nephrol 12: 1685-1695.
55. Kogawa K, Ogawa K, Hayashi Y, Nakamura T, Titani K, Sugino H (1991) Immunohistochemical localization of follistatin in rat tissues. Endocrinol Jpn 38: 383-391.
56. Witzgall R, Brown D, Schwarz C, Bonventre JV (1994) Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 93: 2175-2188.
57. Dressler GR (2006) The cellular basis of kidney development. Annu Rev Cell Dev Biol 22: 509-529.
58. Torres M, Gomez-Pardo E, Dressler GR, Gruss P (1995) Pax-2 controls multiple steps of urogenital de velopment. Development 121: 4057-4065.
59. Dressler GR, Wilkinson JE, Rothenpieler UW, Patterson LT, Williams-Simons L, Westphal H (1993) Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature 362: 65-67.
60. Winyard PJ, Risdon RA, Sams VR, Dressler GR, Woolf AS (1996) The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest 98: 451-459.
61. Imgrund M, Grone E, Grone HJ, Kretzler M, Holzman L, Schlondorff D, Rothenpieler UW (1999) Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice 1. Kidney Int 56: 1423-1431.
62. Maeshima A, Maeshima K, Nojima Y, Kojima I (2002) Involvement of Pax-2 in the action of activin A on tubular cell regeneration. J Am Soc Nephrol 13: 2850-2859.
63. Maeshima A, Nojima Y, Kojima I (2002) Activin A: an autocrine regulator of cell growth and differentiation in renal proximal tubular cells. Kidney Int 62: 446-454.
64. Yamashita S, Maeshima A, Kojima I, Nojima Y (2004) Activin A is a potent activator of renal interstitial fibroblasts. J Am Soc Nephrol 15: 91-101.
65. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL (2002) Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297: 2256-2259.
66. Gaedeke J, Boehler T, Budde K, Neumayer HH, Peters H (2005) Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis. Nephrol Dial Transplant 20: 319-328.
67. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E (2004) Defining the epithelial stem cell niche in skin. Science 303: 359-363.