메뉴 건너뛰기




Volumn 141, Issue 3, 2008, Pages 357-366

Genetic modifiers of the β-haemoglobinopathies

Author keywords

thalassaemia; Genome wide association study; Quantitative trait loci; Sickle cell disease

Indexed keywords

BILIRUBIN; HEMOGLOBIN F;

EID: 42049105635     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07084.x     Document Type: Conference Paper
Times cited : (127)

References (101)
  • 4
    • 0019302053 scopus 로고
    • Construction of a genetic linkage map in man using restriction fragment length polymorphisms
    • Botstein, D., White, R.L., Skolnick, M. Davis, R.W. (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics, 32, 314 331.
    • (1980) American Journal of Human Genetics , vol.32 , pp. 314-331
    • Botstein, D.1    White, R.L.2    Skolnick, M.3    Davis, R.W.4
  • 7
    • 0019518167 scopus 로고
    • Interaction between homozygous β thalassaemia and the Swiss type of hereditary persistence of fetal haemoglobin
    • Cappellini, M.D., Fiorelli, G. Bernini, L.F. (1981) Interaction between homozygous β thalassaemia and the Swiss type of hereditary persistence of fetal haemoglobin. British Journal of Haematology, 48, 561 572.
    • (1981) British Journal of Haematology , vol.48 , pp. 561-572
    • Cappellini, M.D.1    Fiorelli, G.2    Bernini, L.F.3
  • 8
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
    • Carlson, C.S., Eberle, M.A., Rieder, M.J., Yi, Q., Kruglyak, L. Nickerson, D.A. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American Journal of Human Genetics, 74, 106 120.
    • (2004) American Journal of Human Genetics , vol.74 , pp. 106-120
    • Carlson, C.S.1    Eberle, M.A.2    Rieder, M.J.3    Yi, Q.4    Kruglyak, L.5    Nickerson, D.A.6
  • 10
    • 0028897283 scopus 로고
    • An analysis of fetal hemoglobin variation in sickle cell disease: The relative contributions of the X-linked factor, β-globin haplotypes, α-globin gene number, gender and age
    • Chang, Y.C., Smith, K.D., Moore, R.D., Serjeant, G.R. Dover, G.J. (1995) An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, β-globin haplotypes, α-globin gene number, gender and age. Blood, 85, 1111 1117.
    • (1995) Blood , vol.85 , pp. 1111-1117
    • Chang, Y.C.1    Smith, K.D.2    Moore, R.D.3    Serjeant, G.R.4    Dover, G.J.5
  • 11
    • 0014404927 scopus 로고
    • Separation of the alpha and beta chains of human haemoglobin
    • Clegg, J.B., Naughton, M.A. Weatherall, D.J. (1968) Separation of the alpha and beta chains of human haemoglobin. Nature, 219, 69 70.
    • (1968) Nature , vol.219 , pp. 69-70
    • Clegg, J.B.1    Naughton, M.A.2    Weatherall, D.J.3
  • 12
    • 9144248512 scopus 로고    scopus 로고
    • Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults
    • Close, J., Game, L., Clark, B.E., Bergounioux, J., Gerovassili, A. Thein, S.L. (2004) Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults. BMC Genomics, 5, 33.
    • (2004) BMC Genomics , vol.5 , pp. 33
    • Close, J.1    Game, L.2    Clark, B.E.3    Bergounioux, J.4    Gerovassili, A.5    Thein, S.L.6
  • 14
    • 0026708201 scopus 로고
    • Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2
    • Dover, G.J., Smith, K.D., Chang, Y.C., Purvis, S., Mays, A., Meyers, D.A., Sheils, C. Serjeant, G. (1992) Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood, 80, 816 824.
    • (1992) Blood , vol.80 , pp. 816-824
    • Dover, G.J.1    Smith, K.D.2    Chang, Y.C.3    Purvis, S.4    Mays, A.5    Meyers, D.A.6    Sheils, C.7    Serjeant, G.8
  • 15
    • 0026570768 scopus 로고
    • DNA sequence variation in a negative control region 5′ to the beta-globin gene correlates with the phenotypic expression of the beta s mutation
    • Elion, J., Berg, P.E., Lapoumeroulie, C., Trabuchet, G., Mittelman, M., Krishnamoorthy, R., Schechter, A.N. Labie, D. (1992) DNA sequence variation in a negative control region 5′ to the beta-globin gene correlates with the phenotypic expression of the beta s mutation. Blood, 79, 787 792.
    • (1992) Blood , vol.79 , pp. 787-792
    • Elion, J.1    Berg, P.E.2    Lapoumeroulie, C.3    Trabuchet, G.4    Mittelman, M.5    Krishnamoorthy, R.6    Schechter, A.N.7    Labie, D.8
  • 18
    • 0043133530 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1 gene promoter polymorphism is associated with increased serum bilirubin levels and cholecystectomy in patients with sickle cell anemia
    • Fertrin, K.Y., Melo, M.B., Assis, A.M., Saad, S.T. Costa, F.F. (2003) UDP-glucuronosyltransferase 1 gene promoter polymorphism is associated with increased serum bilirubin levels and cholecystectomy in patients with sickle cell anemia. Clinical Genetics, 64, 160 162.
    • (2003) Clinical Genetics , vol.64 , pp. 160-162
    • Fertrin, K.Y.1    Melo, M.B.2    Assis, A.M.3    Saad, S.T.4    Costa, F.F.5
  • 19
    • 0032429141 scopus 로고    scopus 로고
    • The population genetics of the haemoglobinopathies
    • In: ed. by. G.P. Rodgers. pp. Bailliere Tindall, London.
    • Flint, J., Harding, R.M., Boyce, A.J. Clegg, J.B. (1998) The population genetics of the haemoglobinopathies. In : Bailliére's Clinical Haematology (ed. by G.P. Rodgers Vol. 11, pp. 1 52. Bailliere Tindall, London.
    • (1998) Bailliére's Clinical Haematology , vol.11 , pp. 1-52
    • Flint, J.1    Harding, R.M.2    Boyce, A.J.3    Clegg, J.B.4
  • 20
    • 0000844285 scopus 로고    scopus 로고
    • Molecular mechanisms of beta thalassemia
    • In: ed. by. M.H. Steinberg, B.G. Forget, D.R. Higgs. R.L. Nagel. pp. Cambridge University Press, Cambridge, UK.
    • Forget, B.G. (2001) Molecular mechanisms of beta thalassemia. In : Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (ed. by M.H. Steinberg, B.G. Forget, D.R. Higgs R.L. Nagel pp. 252 276. Cambridge University Press, Cambridge, UK.
    • (2001) Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management , pp. 252-276
    • Forget, B.G.1
  • 21
    • 0021067375 scopus 로고
    • A family with segregating triplicated alpha globin loci and β thalassaemia
    • Galanello, R., Ruggeri, R., Paglietti, E., Addis, M., Melis, M.A. Cao, A. (1983) A family with segregating triplicated alpha globin loci and β thalassaemia. Blood, 62, 1035 1040.
    • (1983) Blood , vol.62 , pp. 1035-1040
    • Galanello, R.1    Ruggeri, R.2    Paglietti, E.3    Addis, M.4    Melis, M.A.5    Cao, A.6
  • 27
    • 0008445052 scopus 로고    scopus 로고
    • A candidate gene study of F cell levels in sibling pairs using a joint linkage and association analysis
    • Garner, C., Tatu, T., Game, L., Cardon, L.R., Spector, T.D., Farrall, M. Thein, S.L. (2000b) A candidate gene study of F cell levels in sibling pairs using a joint linkage and association analysis. GeneScreen, 1, 9 14.
    • (2000) GeneScreen , vol.1 , pp. 9-14
    • Garner, C.1    Tatu, T.2    Game, L.3    Cardon, L.R.4    Spector, T.D.5    Farrall, M.6    Thein, S.L.7
  • 28
    • 0036181252 scopus 로고    scopus 로고
    • Evidence for genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin
    • Garner, C., Tatu, T., Best, S., Creary, L. Thein, S.L. (2002) Evidence for genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin. American Journal of Human Genetics, 70, 793 799.
    • (2002) American Journal of Human Genetics , vol.70 , pp. 793-799
    • Garner, C.1    Tatu, T.2    Best, S.3    Creary, L.4    Thein, S.L.5
  • 29
    • 4644344794 scopus 로고    scopus 로고
    • Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin
    • Garner, C., Silver, N., Best, S., Menzel, S., Martin, C., Spector, T.D. Thein, S.L. (2004) Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin. Blood, 104, 2184 2186.
    • (2004) Blood , vol.104 , pp. 2184-2186
    • Garner, C.1    Silver, N.2    Best, S.3    Menzel, S.4    Martin, C.5    Spector, T.D.6    Thein, S.L.7
  • 30
    • 0021359892 scopus 로고
    • Heterocellular HPFH: Molecular mechanisms of abnormal g gene expression in association with β thalassemia and linkage relationship with the β globin gene cluster
    • Giampaolo, A., Mavilio, F., Sposi, N.M., Care, A., Massa, A., Cianetti, L., Petrini, M., Russo, R., Capellini, M.D. Marinucci, M. (1984) Heterocellular HPFH: molecular mechanisms of abnormal g gene expression in association with β thalassemia and linkage relationship with the β globin gene cluster. Human Genetics, 66, 151 156.
    • (1984) Human Genetics , vol.66 , pp. 151-156
    • Giampaolo, A.1    Mavilio, F.2    Sposi, N.M.3    Care, A.4    Massa, A.5    Cianetti, L.6    Petrini, M.7    Russo, R.8    Capellini, M.D.9    Marinucci, M.10
  • 34
    • 38349036151 scopus 로고    scopus 로고
    • Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency
    • Gordeuk, V.R., Sachdev, V., Taylor, J.G., Gladwin, M.T., Kato, G. Castro, O.L. (2007) Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency. American Journal of Hematology, 83, 15 18.
    • (2007) American Journal of Hematology , vol.83 , pp. 15-18
    • Gordeuk, V.R.1    Sachdev, V.2    Taylor, J.G.3    Gladwin, M.T.4    Kato, G.5    Castro, O.L.6
  • 36
    • 0037388172 scopus 로고    scopus 로고
    • UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia
    • Heeney, M.M., Howard, T.A., Zimmerman, S.A. Ware, R.E. (2003) UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia. Journal of Laboratory and Clinical Medicine, 141, 279 282.
    • (2003) Journal of Laboratory and Clinical Medicine , vol.141 , pp. 279-282
    • Heeney, M.M.1    Howard, T.A.2    Zimmerman, S.A.3    Ware, R.E.4
  • 37
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze, M.W., Muckenthaler, M.U. Andrews, N.C. (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell, 117, 285 297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 39
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn, J.N. Daly, M.J. (2005) Genome-wide association studies for common diseases and complex traits. Nature Reviews Genetics, 6, 95 108.
    • (2005) Nature Reviews Genetics , vol.6 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 41
    • 0031972656 scopus 로고    scopus 로고
    • Beta thalassemia intermedia: Is it possible to consistently predict phenotype from genotype?
    • Ho, P.J., Hall, G.W., Luo, L.Y., Weatherall, D.J. Thein, S.L. (1998) Beta thalassemia intermedia: is it possible to consistently predict phenotype from genotype? British Journal of Haematology, 100, 70 78.
    • (1998) British Journal of Haematology , vol.100 , pp. 70-78
    • Ho, P.J.1    Hall, G.W.2    Luo, L.Y.3    Weatherall, D.J.4    Thein, S.L.5
  • 46
    • 0017253381 scopus 로고
    • Sickle β-thalassemia: Identical twins differing in severity implicate nongenetic factors influencing course
    • Joishy, S.K., Griner, P.F. Rowley, P.T. (1976) Sickle β-thalassemia: identical twins differing in severity implicate nongenetic factors influencing course. American Journal of Hematology, 1, 23 33.
    • (1976) American Journal of Hematology , vol.1 , pp. 23-33
    • Joishy, S.K.1    Griner, P.F.2    Rowley, P.T.3
  • 51
    • 0006866822 scopus 로고    scopus 로고
    • MTHFR (5,10 methylenetetrahydrofolate reductase) 677->T mutation as a candidate risk factor for avascular necrosis (AVN) in patients with sickle cell disease
    • Kutlar, F., Tural, C., Park, D., Markowitz, R.B., Woods, K.F. Kutlar, A. (1998) MTHFR (5,10 methylenetetrahydrofolate reductase) 677->T mutation as a candidate risk factor for avascular necrosis (AVN) in patients with sickle cell disease. Blood (ASH Annual Meeting Abstracts), 92, 695a.
    • (1998) Blood (ASH Annual Meeting Abstracts) , vol.92
    • Kutlar, F.1    Tural, C.2    Park, D.3    Markowitz, R.B.4    Woods, K.F.5    Kutlar, A.6
  • 56
    • 0037071604 scopus 로고    scopus 로고
    • Physiology: Haemoglobin's chaperone
    • Luzzatto, L. Notaro, R. (2002) Physiology: haemoglobin's chaperone. Nature, 417, 703 705.
    • (2002) Nature , vol.417 , pp. 703-705
    • Luzzatto, L.1    Notaro, R.2
  • 57
    • 0024385307 scopus 로고
    • A case of hereditary persistence of fetal hemoglobin caused by a gene not linked to the β-globin cluster
    • Martinez, G., Novelletto, A., Di Rienzo, A., Felicetti, L. Colombo, B. (1989) A case of hereditary persistence of fetal hemoglobin caused by a gene not linked to the β-globin cluster. Human Genetics, 82, 335 337.
    • (1989) Human Genetics , vol.82 , pp. 335-337
    • Martinez, G.1    Novelletto, A.2    Di Rienzo, A.3    Felicetti, L.4    Colombo, B.5
  • 59
    • 0022001839 scopus 로고
    • Hematologically and genetically distinct forms of sickle cell anemia in Africa. the Senegal type and the Benin type
    • Nagel, R.L., Fabry, M.E., Pagnier, J., Zohoun, I., Wajcman, H., Baudin, V. Labie, D. (1985) Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. New England Journal of Medicine, 312, 880 884.
    • (1985) New England Journal of Medicine , vol.312 , pp. 880-884
    • Nagel, R.L.1    Fabry, M.E.2    Pagnier, J.3    Zohoun, I.4    Wajcman, H.5    Baudin, V.6    Labie, D.7
  • 62
    • 0020064422 scopus 로고
    • Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin
    • Old, J.M., Ayyub, H., Wood, W.G., Clegg, J.B. Weatherall, D.J. (1982) Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin. Science, 215, 981 982.
    • (1982) Science , vol.215 , pp. 981-982
    • Old, J.M.1    Ayyub, H.2    Wood, W.G.3    Clegg, J.B.4    Weatherall, D.J.5
  • 64
    • 0025612129 scopus 로고
    • Intrinsic potential for high fetal hemoglobin production in a Druze family with β-thalassaemia is due to an unlinked genetic determinant
    • Oppenheim, A., Yaari, A., Rund, D., Rachmilewitz, E.A., Nathan, D., Wong, C., Kazazian, Jr., H.H. Miller, B. (1990) Intrinsic potential for high fetal hemoglobin production in a Druze family with β-thalassaemia is due to an unlinked genetic determinant. Human Genetics, 86, 175 180.
    • (1990) Human Genetics , vol.86 , pp. 175-180
    • Oppenheim, A.1    Yaari, A.2    Rund, D.3    Rachmilewitz, E.A.4    Nathan, D.5    Wong, C.6    Kazazian Jr., H.H.7    Miller, B.8
  • 66
    • 0019949838 scopus 로고
    • Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster
    • Orkin, S.H., Kazazian, H.H.J., Antonarakis, S.E., Goff, S.C., Boehm, C.D., Sexton, J.P., Waber, P.G. Giardina, P.J.V. (1982) Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature, 296, 627 631.
    • (1982) Nature , vol.296 , pp. 627-631
    • Orkin, S.H.1    Kazazian, H.H.J.2    Antonarakis, S.E.3    Goff, S.C.4    Boehm, C.D.5    Sexton, J.P.6    Waber, P.G.7    Giardina, P.J.V.8
  • 67
    • 0034760144 scopus 로고    scopus 로고
    • Influence of bilirubin uridine diphosphate- glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia
    • Passon, R.G., Howard, T.A., Zimmerman, S.A., Schultz, W.H. Ware, R.E. (2001) Influence of bilirubin uridine diphosphate- glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. American Journal of Pediatric Hematology/Oncology, 23, 448 451.
    • (2001) American Journal of Pediatric Hematology/Oncology , vol.23 , pp. 448-451
    • Passon, R.G.1    Howard, T.A.2    Zimmerman, S.A.3    Schultz, W.H.4    Ware, R.E.5
  • 68
    • 0028238339 scopus 로고
    • A potential regulatory region for the expression of fetal hemoglobin in sickle cell disease
    • Pissard, S. Beuzard, Y. (1994) A potential regulatory region for the expression of fetal hemoglobin in sickle cell disease. Blood, 84, 331 338.
    • (1994) Blood , vol.84 , pp. 331-338
    • Pissard, S.1    Beuzard, Y.2
  • 72
    • 0030663191 scopus 로고    scopus 로고
    • The expression of uridine diphosphate glucuronosyltransferase gene is a major determinant of bilirubin level in heterozygous beta-thalassaemia and in glucose-6-phosphate
    • Sampietro, M., Lupica, L., Perrero, L., Comino, A. Martinez di Montemuros, F. (1997) The expression of uridine diphosphate glucuronosyltransferase gene is a major determinant of bilirubin level in heterozygous beta-thalassaemia and in glucose-6-phosphate. British Journal of Haematology, 99, 437 439.
    • (1997) British Journal of Haematology , vol.99 , pp. 437-439
    • Sampietro, M.1    Lupica, L.2    Perrero, L.3    Comino, A.4    Martinez Di Montemuros, F.5
  • 74
    • 16844366938 scopus 로고    scopus 로고
    • Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia
    • Sebastiani, P., Ramoni, M.F., Nolan, V., Baldwin, C.T. Steinberg, M.H. (2005) Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nature Genetics, 37, 435 440.
    • (2005) Nature Genetics , vol.37 , pp. 435-440
    • Sebastiani, P.1    Ramoni, M.F.2    Nolan, V.3    Baldwin, C.T.4    Steinberg, M.H.5
  • 77
    • 0030806361 scopus 로고    scopus 로고
    • Ubiquitin aldehyde increases adenosine triphosphate-dependent proteolysis of hemoglobin alpha-subunits in beta-thalassemic hemolysates
    • Shaeffer, J.R. Cohen, R.E. (1997) Ubiquitin aldehyde increases adenosine triphosphate-dependent proteolysis of hemoglobin alpha-subunits in beta-thalassemic hemolysates. Blood, 90, 1300 1308.
    • (1997) Blood , vol.90 , pp. 1300-1308
    • Shaeffer, J.R.1    Cohen, R.E.2
  • 78
    • 1642458091 scopus 로고    scopus 로고
    • Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease
    • Sharan, K., Surrey, S., Ballas, S., Borowski, M., Devoto, M., Wang, K.F., Sandler, E. Keller, M. (2004) Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. British Journal of Haematology, 124, 240 243.
    • (2004) British Journal of Haematology , vol.124 , pp. 240-243
    • Sharan, K.1    Surrey, S.2    Ballas, S.3    Borowski, M.4    Devoto, M.5    Wang, K.F.6    Sandler, E.7    Keller, M.8
  • 79
    • 0022808364 scopus 로고
    • Alpha-thalassemia in blacks: Genetic and clinical aspects and interactions with the sickle hemoglobin gene
    • Steinberg, M.H. Embury, S.H. (1986) Alpha-thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene. Blood, 68, 985 990.
    • (1986) Blood , vol.68 , pp. 985-990
    • Steinberg, M.H.1    Embury, S.H.2
  • 84
    • 0032709384 scopus 로고    scopus 로고
    • Is it dominantly inherited beta thalassaemia or just a beta-chain variant that is highly unstable?
    • Thein, S.L. (1999) Is it dominantly inherited beta thalassaemia or just a beta-chain variant that is highly unstable? British Journal of Haematology, 107, 12 21.
    • (1999) British Journal of Haematology , vol.107 , pp. 12-21
    • Thein, S.L.1
  • 85
    • 0002239451 scopus 로고    scopus 로고
    • Structural variants with a beta-thalassemia phenotype
    • In: ed. by. M.H. Steinberg, B.G. Forget, D.R. Higgs. R.L. Nagel. pp. Cambridge University Press, Cambridge, UK.
    • Thein, S.L. (2001) Structural variants with a beta-thalassemia phenotype. In : Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (ed. by M.H. Steinberg, B.G. Forget, D.R. Higgs R.L. Nagel pp. 342 355. Cambridge University Press, Cambridge, UK.
    • (2001) Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management , pp. 342-355
    • Thein, S.L.1
  • 86
    • 20344382303 scopus 로고    scopus 로고
    • Genetic modifiers of beta-thalassemia
    • Thein, S.L. (2005) Genetic modifiers of beta-thalassemia. Haematologica, 90, 649 660.
    • (2005) Haematologica , vol.90 , pp. 649-660
    • Thein, S.L.1
  • 87
    • 0032406849 scopus 로고    scopus 로고
    • Genetics of Hb F/F cell variance in adults and heterocellular hereditary persistence of fetal hemoglobin
    • Thein, S.L. Craig, J.E. (1998) Genetics of Hb F/F cell variance in adults and heterocellular hereditary persistence of fetal hemoglobin. Hemoglobin, 22, 401 414.
    • (1998) Hemoglobin , vol.22 , pp. 401-414
    • Thein, S.L.1    Craig, J.E.2
  • 88
    • 0024780661 scopus 로고
    • A non-deletion hereditary persistance of fetal hemoglobin (HPFH) determinant not linked to the beta-globin gene complex
    • In: ed. by. G. Stamatoyannopoulos. A.W. Nienhuis. pp. Alan R Liss, Inc., New York.
    • Thein, S.L. Weatherall, D.J. (1989) A non-deletion hereditary persistance of fetal hemoglobin (HPFH) determinant not linked to the beta-globin gene complex. In : Hemoglobin Switching, Part B: Cellular and Molecular Mechanisms (ed. by G. Stamatoyannopoulos A.W. Nienhuis pp. 97 111. Alan R Liss, Inc., New York.
    • (1989) Hemoglobin Switching, Part B: Cellular and Molecular Mechanisms , pp. 97-111
    • Thein, S.L.1    Weatherall, D.J.2
  • 92
    • 0030890407 scopus 로고    scopus 로고
    • Benign clinical course in homozygous sickle cell disease: A search for predictors
    • Thomas, P.W., Higgs, D.R. Serjeant, G.R. (1997) Benign clinical course in homozygous sickle cell disease: a search for predictors. Journal of Clinical Epidemiology, 50, 121 126.
    • (1997) Journal of Clinical Epidemiology , vol.50 , pp. 121-126
    • Thomas, P.W.1    Higgs, D.R.2    Serjeant, G.R.3
  • 96
    • 0013846440 scopus 로고
    • Globin synthesis in thalassemia: An in vitro study
    • Weatherall, D.J., Clegg, J.B. Naughton, D.G. (1965) Globin synthesis in thalassemia: an in vitro study. Nature, 208, 1061 1065.
    • (1965) Nature , vol.208 , pp. 1061-1065
    • Weatherall, D.J.1    Clegg, J.B.2    Naughton, D.G.3
  • 98
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium (
    • Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661 678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 101
    • 0031724415 scopus 로고    scopus 로고
    • Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease
    • Zimmerman, S.A. Ware, R.E. (1998) Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. American Journal of Hematology, 59, 267 272.
    • (1998) American Journal of Hematology , vol.59 , pp. 267-272
    • Zimmerman, S.A.1    Ware, R.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.