Evidence of genetic interaction between the β-globin complex and chromosome 8q in the expression of fetal hemoglobin

American Journal of Human Genetics

Volumn 70, Issue 3, 2002, Pages 793-799

  Garner, Chad P ^a   Tatu, Thanusak ^b   Best, Steve ^b   Creary, Lisa ^b   Thein, Swee Lay ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; HEMOGLOBIN F; TRANSCRIPTION FACTOR;

ARTICLE; CHROMOSOME 8Q; DNA FLANKING REGION; ERYTHROCYTE; FETUS; GENE EXPRESSION; GENE INTERACTION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

EID: 0036181252     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/339248     Document Type: Article

References (26)

1. Fetal hemoglobin restriction to a few erythrocytes (F cells) in normal human adults
2. Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach
3. The molecular basis of HPFH in a British family identified by heteroduplex formation
4. A comprehensive genetic map of the human genome based on 5,264 microsatellites
5. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2
6. Variation in hemoglobin F production among normal and sickle cell adults is not related to nucleotide substitutions in the gamma promoter regions
7. A candidate gene study of F cell levels in sibling pairs with joint linkage and association analysis
8. Genetic influences on F cells and other hematological variables: A twin heritability study
9. DNA sequence variation associated with elevated fetal Gγ-globin production
10. Beta-thalassemia intermedia: Is it possible to consistently predict phenotype from genotype?
11. An STS-based map of the human genome
12. Eukaryotic transcription: An interlaced network of transcription factors and chromatic-modifying machines
13. Common haplotype dependency of high Gγ-globin gene expression and high Hb F levels in β-thalassemia and sickle cell anemia patients
14. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
15. X-linked dominant control of F-cells in normal adult life: Characterization of the Swiss type as hereditary persistence of fetal hemoglobin regulated dominantly by gene(s) on X chromosome
16. Analysis of family resemblance. III. Complex segregation analysis of complex traits
17. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance
18. PedCheck: A program for identification of genotype incompatibilities in linkage analysis
19. Variation of HbF and F-cell number with the G-gamma Xmn I (C-T) polymorphism in normal individuals
20. Association of thalassaemia intermedia with a beta-globin gene haplotype
21. A non-deletion hereditary persistence of fetal hemoglobin (HPFH) determinant not linked to the β-globin gene complex
22. Detection of a major gene for heterocellular hereditary persistence of fetal hemoglobin after accounting for genetic modifiers
23. Hereditary persistence of fetal hemoglobin and δβ-thalassemia
24. Genetic control of F cells in human adults