Association of hyperhomocysteinemia with osteoporosis: A systematic review

Therapy

Volumn 5, Issue 2, 2008, Pages 215-222

  Salari, Pooneh ^a   Larijani, Bagher ^a   Abdollahi, Mohammad ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bone health; Homocysteine; Osteoporosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALENDRONIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE;

AMINO ACID BLOOD LEVEL; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERALIZATION; BONE STRENGTH; BONE TURNOVER; CLINICAL TRIAL; DISEASE COURSE; DISEASE MARKER; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; FOLIC ACID DEFICIENCY; FRAGILITY FRACTURE; GENETIC PREDISPOSITION; HOMOCYSTEINE BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; NUTRITIONAL STATUS; OSTEOLYSIS; OSTEOPOROSIS; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PERNICIOUS ANEMIA; POSTMENOPAUSE OSTEOPOROSIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SYSTEMATIC REVIEW; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 41949125462     PISSN: 14750708     EISSN: 1744831X     Source Type: Journal    
DOI: 10.2217/14750708.5.2.215     Document Type: Review

References (59)

1. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al.: Homocysteine levels and the risk of osteoporotic fracture. N. Engl. J. Med. 350(20), 2033-2041 (2004).
2. McLean RR, Jacques PF, Selhub J et al.: Homocysteine as a predictive factor for hip fracture in older persons. N. Engl. J. Med. 350(20), 2042-2049 (2004).
3. Herrmann M, Stanger O, Paulweber B, Hufnagl C, Herrmann W: Folate supplementation does not affect biochemical markers of bone turnover. Clin. Lab. 52(3-4), 131-136 (2006).
4. Chrischilles E, Shireman T, Wallace R: Costs and health effects of osteoporotic fractures. Bone 15(4), 377-386 (1994).
5. Herrmann W, Herrmann M, Obeid R: Hyperhomocysteinaemia: a critical review of old and new aspects. Curr. Drug Metab. 8(1), 17-31 (2007).
6. Jacques PF, Rosenberg IH, Rogers G et al.: Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 69(3), 482-489 (1999).
7. Herrmann W, Schorr H, Bodis M et al.: Role of homocysteine, cystathionine, and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects. Eur. J. Clin. Invest. 30(12), 1083-1089 (2000).
8. Herrmann W, Quast S, Ullrich M, Schultze H, Bodis M, Geisel J: Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation. Atherosclerosis 144(1), 91-101 (1999).
9. Seshadri S, Beiser A, Selhub J, et al.: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346, 476-483 (2002).
10. Vilaseca MA, Moyano D, Ferrer I, Artuch R: Total homocysteine in pediatric patients. Clin. Chem. 43(4), 690-692 (1997).
11. Grieco AJ: Homocystinuria: pathogenic mechanisms. Am. J. Med. Sci. 273, 120-132 (1977).
12. Morreels CL, Fletcher BD, Weilbaecher RG, Dorst JP: The roentgenographic features of homocystinuria. Radiology 90(6), 1150-1158 (1968).
13. Mudd SH, Skovby F, Levy HL et al.: The natural history of homocystinuria due to cystathionine β-synthase deficiency. Am. J. Hum. Genet. 37(1), 1-31 (1985).
14. Cooper C: The crippling consequences of fractures and their impact on quality of life. Am. J. Med. 103(Suppl. 2A), S12-S19 (1997).
15. Ray NF, Chan JK, Thamer M. Melton LJ 3rd: Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis in Foundation. J. Bone Miner. Res. 12(1), 24-35 (1997).
16. Browner WS, Pressman AR, Nevitt MC, Cummings SR: Mortality following fractures in older women: the study of the Osteoporotic Fractures. Arch. Intern. Med. 156(14), 1521-1525 (1996).
17. McKusick VA: Inheritable Disorders of Connective Tissue. CV Mosby, St Louis, USA, 155 (1966).
18. Parrot F, Redonnet-Vernhet I, Lacombe D, Gin H: Osteoporosis in late-diagnosed adult homocystinuric patients. J. Inherit. Metab. Dis. 23(4), 338-340 (2000).
19. Perez-Castrillon JL, Arranz-Pena ML, Luis DD: Homocysteine as a predictive, factor for hip fracture in older persons. N Engl. J. Med. 351, 1027-1030 (2004).
20. Whiting SJ, Draper HH: Effect of a chronic acid load as sulfate or sulfur amino acids on bone metabolism in adult rats. J. Nutr. 111. 1721-1726 (1981).
21. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH: Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim. Biophys. Acta 1315, 159-162 (1996).
22. Khan M, Yamauchi M, Srisawasdi S et al.: Homocysteine decreases chondrocytemediated matrix mineralization in differentiating chick limb-bud mesenchymal cell micro-mass cultures. Bone 28, 387-398 (2001).
23. Golbahar J, Aminzadeh MA, Hamidi SA, Omrani GR: Association of red blood cell 5-methyltetrahydrofolate with bone mineral density in postmenopausal Iranian women. Osteoporosis Int. 16, 1894-1898 (2005).
24. McLean RR, Karasik D, Selhub J et al.: Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J. Bone Miner. Res. 19(3), 410-418 (2004).
25. Périer MA, Gineyts E, Munoz F, Sornay-Rendu E, Delmas PD: Homocysteine and fracture risk in postmenopausal women: the OFELY study. Osteopanisis Int. 18(10), 1329-1336 (2007).
26. Herrmann M, Widmann T, Herrmann W: Homocysteine: a newly recognised risk factor for osteoporosis. Clin. Chem. Lab. Med. 43(10), 1111-1117 (2005).
27. Herrmann M, Kraenzlin M, Pape G, Sand-Hill M, Herrmann W: Relation between hornocysteine and biochemical bone turnover markers and bone mineral density in peri- and postmenopausal women: a cross-sectional study. Clin. Chem. Lab. Med. 43(10), 1118-1123 (2005).
28. Cagnacci A, Baldassari F, Rivolta G, Arangino, S, Volpe A: Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone 33(6), 956-959 (2003).
29. Golbahar J, Hamidi A, Aminzadeh MA, Omrani GR: Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C677T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone 35(3), 760-765 (2004).
30. Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, Staveren WA: Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J. Bone Miner. Res. 20(6), 921-929 (2005).
31. Gerdhem P, Ivaska KK, Isaksson A et al.: Association between homocysteine, bone turn over, bone mineral density and fracture risk in elderly women. J. Bone Miner. Res. 22, 127-134 (2007).
32. Kim DJ, Koh JM, Lee O et al.: Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 39, 582-590 (2006).
33. Koh JM, Lee YS, Kim YS et al.: Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased Intracellular ROS generation. J. Bone Miner. Res. 21(7), 1003-1011 (2006).
34. Herrmann M, Umanskaya N, Wildemann B et al.: Accumulation of homocysteien by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro. Clinic. Chim. Acta 384, 129-134 (2007).
35. Herrmann M, Wildemann B, Claes L et al.: Experimental hyperhomocysteinemia reduces bone quality in rats. Clin. Chem. 53(8), 1455-1461 (2007).
36. Ozdem S, Samanaci S, Taatarqil A et al.: Experimental hyperhomocysteinemia disturbs bone metabolism in rats. Scand. J. Clin. Lab. Invest. 67(7), 748-756 (2007).
37. Carmel R, Lau KH, Baylink DJ, Saxena S, Singer FR: Cobalarnin and osteoblast-specific proteins. N. Engl. J. Med. 319(2), 70-75 (1988).
38. Kim GS, Kim CH, Park JY, Lee KU, Park CS: Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism 45(12), 1443-1446 (1996).
39. Goerss JB, Kim CH, Atkinson EJ, Eastell R, O'Eallon WM, Melton LJ: Risk of fractures in patients with pernicious anemia. J. Bone Miner. Res. 7(5), 573-9 (1992).
40. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K: Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 293(9), 1082-1088 (2005).
41. Gjesdal CG, Vollset SE, Ueland PM et al.: Plasma total homocysteine level and bone mineral density. Arch. Intern. Med. 166, 88-94 (2006).
42. Green TJ, McMahon JA, Skeaff CM, Williams SM, Whiting SJ: Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial. Am. J. Clin. Nutr. 35, 460-464 (2007).
43. Bathum L, von Bornemann HJ, Christiansen L, Madsen JS, Skytthe A, Christiansen K: Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population- based Danish study. Osteoporos Int. 15 (8), 659-664 (2004).
44. Abrahamsen B, Madsen JS, Tofteng CL et al.: A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study.J. Bone Miner. Res. 18(4), 723-729 (2003).
45. Villadsen MM, Bunger MH, Carstens M, Stenkjaer L, Langdahl BL: Methylenetetrahydrofolate red actase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak puedictor of BMD. Osteoporos Int. 16(4), 411-416 (2005).
46. Li M, Lau EMC, Woo J: Methylentetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. Bone 35, 1369-1374 (2004).
47. Abrahamsen B, Madsen JS, Tofteng CL et al.: Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study. Bone 36, 577-583 (2005).
48. Abrahamsen B, Jorgensen HL, Nielsen TL et al.: MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men - results from the Odense Androgen Study. Bone 38, 215-219 (2006).
49. Hong X, Hsu Y-H, Terwedow H et al.: Association of methyltetrahydrofolate reductase C677T porymorphism and fracture risk in Chinese postmenopausal women. Bone 40, 737-742 (2007).
50. Dhonukshe-Rutten RA, Van DM, Schneede J, de Groot LCPGM, van Staveren WA: Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur. J. Nutr. 44(6), 341-347 (2005).
51. Tucker KL, Hannan MT, Qiao N et al.: Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J. Bone Miner. Res. 20(1), 152-158 (2005).
52. Stone KL, Bauer DC, Sellmeyer D, Cummings SR: Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study. J. Clin. Endocrinol. Metab. 89(3), 1217-1221 (2004).
53. Caganacci A, Cannoletta M, Baldassari F, Volpe A: Low vitamin B12 and bone loss: a role for folate deficiency. J Cin. Endocrinol. Metab. 89(9), 4770-4771 (2004).
54. Baines M, Kredan B, Usher J et al.: The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal women. Bone 40(3), 730-736 (2007).
55. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH: Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim. Biophys. Acta 1315 (3), 159-162 (1996).
56. Grant SF, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH: Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α1 gene. Nat. Genet. 14(2), 203-205 (1996).
57. Uitterlinden AG, Burger H, Huang Q et al.: Relation of alleles of the collagen type I αl gene to bone density and the risk of osteoporosis fractures in postmenopausal women. N. Engl. J. Med. 338(15), 1016-1021 (1998).
58. Langdahl BL, Ralston SH, Grant SF, Eriksen EF: An Sp1 binding site polymorphism in the CollA1 gene predicts osteoporotic fractures in both men and women. J. Bone Miner. Res. 13(19), 1384-1389 (1998).
59. Abdollahi M, Larijani B, Rahimi R, Salari P: Role of oxidative stress in osteoporosis. Therapy 2(5), 787-796 (2005).