MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men - Results from the Odense Androgen Study

Bone

Volumn 38, Issue 2, 2006, Pages 215-219

  Abrahamsen, Bo ^a,e   Jørgensen, Henrik L ^b   Nielsen, Torben L ^a   Andersen, Marianne ^a   Haug, Egil ^c   Schwarz, Peter ^d   Hagen, Claus ^a   Brixen, Kim ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c AKER UNIVERSITY HOSPITAL   (Norway)

^d HVIDOVRE HOSPITAL   (Denmark)

^e ROSKILDE HOSPITAL   (Denmark)

Author keywords

BMD; Genetics; Men; Methylene tetrahydrofolate reductase polymorphism; Peak bone mass

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; VITAMIN D;

ADULT; ARTICLE; BONE DENSITOMETRY; BONE MASS; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HIP; HUMAN; HUMAN EXPERIMENT; MALE; OSTEOLYSIS; SMOKING; SPINE;

ADULT; BONE AND BONES; BONE DENSITY; DENMARK; DENSITOMETRY, X-RAY; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIP; HUMANS; LUMBAR VERTEBRAE; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; SPINE;

EID: 31544454979     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2005.08.005     Document Type: Article

References (26)

1. N.A. Pocock, J.A. Eisman, J.L. Hopper, M.G. Yeates, P.N. Sambrook, and S. Eberl Genetic determinants of bone mass in adults. A twin study J. Clin. Invest. 80 1987 706 710
2. C.W. Slemenda, J.C. Christian, C.J. Williams, J.A. Norton, and C.C.J. Johnston Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates J. Bone Miner. Res. 6 1991 561 567
3. S.B. Soroko, E. Barrett Connor, S.L. Edelstein, and D. Kritz Silverstein Family history of osteoporosis and bone mineral density at the axial skeleton: the Rancho Bernardo Study J. Bone Miner. Res. 9 1994 761 769
4. F.E. McGuigan, L. Murray, A. Gallagher, G. Davey-Smith, C.E. Neville, and R. Van't Hof Genetic and environmental determinants of peak bone mass in young men and women J. Bone Miner. Res. 17 2002 1273 1279
5. S.L. Ferrari, S. Deutsch, U. Choudhury, T. Chevalley, J.P. Bonjour, and E.T. Dermitzakis Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites Am. J. Hum. Genet. 74 2004 866 875
6. L. Gennari, L. Masi, D. Merlotti, L. Picariello, A. Falchetti, and A. Tanini A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism J. Clin. Endocrinol. Metab. 89 2004 2803 2810
7. B.L. Langdahl, L. Stenkjaer, M. Carstens, C.L. Tofteng, and E.F. Eriksen A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures Calcif. Tissue Int. 73 2003 237 243
8. Y. Yamada, F. Ando, N. Niino, and H. Shimokata Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men J. Clin. Endocrinol. Metab. 88 2003 3372 3378
9. L.A. Kluijtmans, L.P. van den Heuvel, G.H. Boers, P. Frosst, E.M. Stevens, and B.A. van Oost Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease Am. J. Hum. Genet. 58 1996 35 41
10. H. Morita, J. Taguchi, H. Kurihara, M. Kitaoka, H. Kaneda, and Y. Kurihara Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease Circulation 95 1997 2032 2036
11. B. Abrahamsen, J.S. Madsen, C.L. Tofteng, L. Stilgren, E.M. Bladbjerg, and S.R. Kristensen A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study J. Bone Miner. Res. 18 2003 723 729
12. M. Miyao, H. Morita, T. Hosoi, H. Kurihara, S. Inoue, and S. Hoshino Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women Calcif. Tissue Int. 66 2000 190 194
13. L. Bathum, H.J. von Bornemann, L. Christiansen, J.S. Madsen, A. Skytthe, and K. Christensen Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study Osteoporos Int. 15 2004 659 664
14. H.L. Jorgensen, J.S. Madsen, B. Madsen, M.M. Saleh, B. Abrahamsen, and M. Fenger Association of a Common Allelic Polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish Postmenopausal Women Calcif. Tissue Int. 71 2002 386 392
15. R.R. McLean, D. Karasik, J. Selhub, K.L. Tucker, J.M. Ordovas, and G.T. Russo Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status J. Bone Miner. Res. 19 2004 410 418
16. S.M. Schwartz, D.S. Siscovick, M.R. Malinow, F.R. Rosendaal, R.K. Beverly, and D.L. Hess Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene Circulation 96 1997 412 417
17. P.A. Ashfield-Watt, C.H. Pullin, J.M. Whiting, Z.E. Clark, S.J. Moat, and R.G. Newcombe Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial Am. J. Clin. Nutr. 76 2002 180 186
18. H.M. Macdonald, F.E. McGuigan, W.D. Fraser, S.A. New, S.H. Ralston, and D.M. Reid Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density Bone 35 2004 957 964
19. B. Abrahamsen, J.S. Madsen, C.L. Tofteng, L. Stilgren, E.M. Bladbjerg, and S.R. Kristensen Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish Osteoporosis Prevention Study Bone 36 2005 577 583
20. J. Frystyk, B. Dinesen, and H. Orskov Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II Growth Regul. 5 1995 169 176
21. D. Marshall, O. Johnell, and H. Wedel Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 312 1996 1254 1259
22. B. Lubec, S. Fang-Kircher, T. Lubec, H.J. Blom, and G.H. Boers Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria Biochim. Biophys. Acta 1315 1996 159 162
23. J. Finkelstein The metabolism of homocysteine: pathways and regulation Eur. J. Pediatr. 157 1998 S40 S44
24. M.R. Malinow, F.J. Nieto, W.D. Kruger, P.B. Duell, D.L. Hess, and R.A. Gluckman The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes Arterioscler. Thromb. Vasc. Biol. 17 1997 1157 1162
25. H. McNulty, M.C. McKinley, B. Wilson, J. McPartlin, J.J. Strain, and D.G. Weir Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements Am. J. Clin. Nutr. 76 2002 436 441
26. A.C. Looker Body fat and vitamin D status in black versus white women J. Clin. Endocrinol. Metab. 90 2005 635 640