Homocysteine and fracture risk in postmenopausal women: The OFELY study

Osteoporosis International

Volumn 18, Issue 10, 2007, Pages 1329-1336

  Perier M A ^a,b   Gineyts, E ^a,b   Munoz, F ^a,b   Sornay Rendu, E ^a,b   Delmas, P D ^a,b  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

Fracture; Homocysteine; Osteoporosis; Postmenopausal women; Risk

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CREATININE; HOMOCYSTEINE;

ADULT; AGED; AGING; ARTICLE; BONE DENSITY; BONE FRAGILITY; BONE RADIOGRAPHY; CALCIUM INTAKE; FEMALE; FOLLOW UP; FRACTURE; HUMAN; MAJOR CLINICAL STUDY; NUTRITIONAL ASSESSMENT; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; VERTEBRA FRACTURE;

AGE DISTRIBUTION; AGED; BONE DENSITY; EPIDEMIOLOGIC METHODS; FEMALE; HOMOCYSTEINE; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; SPINAL FRACTURES;

EID: 34548570940     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-007-0393-1     Document Type: Article

References (49)

1. (2001) NIH consensus development panel on osteoporosis. JAMA 285:758-779
2. Braithwaite RS, Col NS, Wong JB (2003) Estimating hip fracture morbidity, mortality and costs. Am Ger Soc 51:364-370
3. Melton LJ III (2000) Who has osteoporosis? A conflict between clinical and Public Health perspectives. J Bone Miner Res 15:2309-2314
4. World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organization, Geneva, Switzerland, pp 1-129
5. Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, Berger ML, Santora AC, Sherwood LM (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286:2815-2822
6. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA (2004) Fracture incidence and associations with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195-202
7. Sornay-Rendu E, Munoz F, Garnero P, Duboeuf F, Delmas PD (2005) Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res 10:1813-1819
8. Albrand G, Munoz F, Sornay-Rendu E, Duboeuf F, Delmas PD (2003) Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. Bone 32:78-85
9. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332:767-773
10. Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J, Fujiwara S, Garnero P, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman A, Tenenhouse A (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375-382
11. Klotzbuecher CM, Ross PD, Landsman PB, Abbott T, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 4:721-739
12. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results of the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947-1954
13. Garnero P, Hausherr E, Chapuy MC, Marcelli C, Grandjean H, Muller C, Cormier C, Breart G, Meunier PJ, Delmas PD (1996) Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Miner Res 11:1531-1538
14. Johnell O, Oden A, de Laet C, Garnero P, Delmas PD, Kanis JA (2002) Biochemical indices of bone turnover and the assessment of fracture probability. Osteoporos Int 13:523-526
15. Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res 15:1526-1536
16. Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD (1997) Undecarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. J Clin Endocrinol Metab 82:719-724
17. Garnero P, Sornay-Rendu E, Delmas PD (2000) Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet 355:898-899
18. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B (1998) Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med 339:733-738
19. Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas PD (2000) Serum estradiol and sex hormone-binding globulin and the risk of fracture in elderly women: the EPIDOS study. J Bone Miner Res 15:1835-1841
20. Finkelstein JD, Martin JJ (2000) Homocysteine. Int J Biochem Cell Biol 32:385-389
21. Scott JM, Weir DG (1998) Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. J Cardiovasc Risk 5:223-227
22. Quéré I, Simorre B, Ruivard M, Le Hello C, Parrot F, Mégnien JL, Touati G, Chassé JF, Saudubray JM, Zittoun J (2001) Homocystinuria in adulthood. Rev Med Int 22:347-355
23. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, Andria G, Boers GH, Bromberg IL, Cerone R (1985) The natural history of homocystinuria due to the cysthathionine beta-synthase deficiency. Am J Hum Genet 37:1-31
24. Grieco AJ (1977) Homocystinuria: pathogenetic mechanisms. Am J Med Sci 273:120-132
25. Mc Lean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042-2049
26. Van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot L, Hofman A, Witteman JCM, van Leeuwen JPTM, Breteler MMB, Lips P, Pols HAP, Uitterlinden AG (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041
27. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Homocysteine as a predictive factor for hip fracture in stroke patients. Bone 36:721-726
28. Sato Y, Iwamoto J, Kanoko T, Satoh K (2005) Homocysteine as a predictive factor for hip fracture in elderly women with Parkinson's disease. Am J Med 118:1250-1255
29. Raisz LG (2004) Homocysteine and osteoporotic fractures: culprit or bystander. N Engl J Med 350:2089-2090
30. Kang AH, Trelstad RL (1973) A collagen defect in homocystinuria. J Clin Invest 52:2571-2578
31. Lubec B, Fang-Kicher S, Lubec T, Blom HJ, Boers GHJ (1996) Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Bioch Biophys Act 1315:159-162
32. Sakamoto W, Isomura H, Fujie K, Deyama Y, Kato A, Nishihira J, Izumi H (2005) Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells. Bioch Biophys Act 1740:12-16
33. Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W (2005) Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem 51:2348-2353
34. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD (1996) Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 11:337-349
35. Genant HK, Wu CY, Van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semi quantitative technique. J Bone Miner Res 8:1137-1148
36. Cummings SR, Nevitt MC, Browner WS (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332:767-773
37. Robbins JA, Schott AM, Garnero P, Delmas PD (2005) Risk factors for hip fracture in women with high BMD. Osteoporos Int 16:149-154
38. Ganji V, Kafai MR (2003) Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 77:826-833
39. Jacques PF, Bostom AG, Wilson PWF, Rich S, Rosenberg ICH, Selhub J (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring Cohort. Am J Clin Nutr 73:613-621
40. Refsum H, Nurk E, Smith D, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygard O, Vollset SE (2006) The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 136:1731-1740
41. Rasmussen LB, Ovesen L, Bülow I, Knudsen N, Laurberg P, Perrild H (2000) Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am J Clin Nutr 72:1156-1163
42. Shimakawa T, Nieto FJ, Malinow MR, Chambless LE, Schreiner PJ, Szklo M (1997) Vitamin intake: a possible determinant of plasma homocysteine among middle-aged adults. Ann Epidemiol 7:285-293
43. Woodside JV, Yarnell JWG, McMaster D, Young IS, Harmon DL, McCrum EE, Patterson CC, Gey KF, Whitehead AS, Evans A (1998) Effect of B-group vitamins and antioxidants vitamins on hyperhomocysteinemia: a double-blind, randomised, factorial-design, controlled trial. Am J Clin Nutr 67:858-865
44. Brönstrup A, Hages M, Prinz-Langenohl R, Pietrzik K (1998) Effect of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women. Am J Clin Nutr 68:1104-1110
45. Ravaglia G, Forti P, Maioli F, Servadei L, Martelli M, Brunetti N, Bastagli L, Cucinotta D, Mariani E (2005) Folate, but not homocysteine, predicts the risk of fracture in elderly persons. J Gerontol A Biol Sci Med Sci 60:1458-1462
46. Dhonukshe-Rutten RAM, Pluijm SMF, de Groot LCPGM, Lips P, Smit JH, van Staveren WA (2005) Homocysteine and vitamin B 12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 20:921-929
47. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Effect of folate and mecobalamin on hip fractures in patients with stroke. JAMA 293:1082-1088
48. Danesh J, Lewington S (1998) Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. J Cardiovasc Risk 5:229-232
49. Guttormsen AB, Schneede J, Fiskerstrand T, Ueland PM, Refsum HM (1994) Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J Nutr 124:1934-1941