In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy- 1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes

Chemical Research in Toxicology

Volumn 17, Issue 7, 2004, Pages 904-913

  Yenes, Susana ^a   Commandeur, Jan N M ^b   Vermeulen, Nico P E ^b   Messeguer, Angel ^a  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3' HYDROXY 3' METHYLBUTYL) 5 METHOXY 1,4 BENZOQUINONE; 2 (3' HYDROXY 3' METHYLBUTYL) 5 METHOXYHYDROQUINONE; 3,4 DIHYDRO 4,6 DIHYDROXY 2,2 DIMETHYL 7 METHOXY 1(2H) BENZOPYRAN; 3,4 DIHYDRO 6 HYDROXY 2,2 DIMETHYL 7 METHOXY 1(2H) BENZOPYRAN; 3,4 DIHYDRO 6,7 DIHYDROXY 2,2 DIMETHYL 1(2H) BENZOPYRAN; BENZOPYRAN DERIVATIVE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A; CYTOCHROME P450 2B; DEXAMETHASONE; ETHOXYRESORUFIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROQUINONE; NITRIC OXIDE; OXASPIRO[4.5] 2,2 DIMETHYL 8 METHOXYDEC 8 ENE 7,10 DIONE; PENTOXYRESORUFIN; PEROXYNITRITE; PHENOBARBITAL; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEALKYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; LIPID PEROXIDATION; LIVER MICROSOME; NONHUMAN; RAT;

ANIMALS; BENZOPYRANS; BIOTRANSFORMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MICROSOMES, LIVER; NITRIC OXIDE; RATS;

ANIMALIA;

EID: 3242727651     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx030036f     Document Type: Article

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