CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3675-3686

  Kulkarni, Shridhar S ^a   Patel, Maulik R ^a   Talele, Tanaji T ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

6,7 Dimethoxy 4 pyrrolidylquinazoline; CoMFA; HQSAR; Phosphodiesterase10A

Indexed keywords

6,7 DIMETHOXY 4 PYRROLIDYLQUINAZOLINE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; BIOLOGICAL ACTIVITY; COMPARATIVE MOLECULAR FIELD ANALYSIS; CORRELATION COEFFICIENT; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTRICITY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTATION; HOLOGRAPHY; MOLECULAR MODEL; PREDICTIVE VALIDITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL SIGNIFICANCE; STEREOSPECIFICITY; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS;

BINDING SITES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES;

EID: 41649094567     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.013     Document Type: Article

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