INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects

International Journal of Obesity

Volumn 31, Issue 11, 2007, Pages 1753-1755

  Smith, A J P ^a   Cooper, J A ^a   Li, L K ^a   Humphries, S E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Genetics; INSIG2; Polymorphism

Indexed keywords

INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; INDIAN; INSULIN INDUCED GENE 2; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION SITE; TRIACYLGLYCEROL BLOOD LEVEL;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CONTINENTAL POPULATION GROUPS; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREAT BRITAIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES;

EID: 35648971173     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803645     Document Type: Article

References (9)

1. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T et al. A common genetic variant is associated with adult and childhood obesity. Science 2006; 312: 279-283.
2. Miller GJ, Bauer KA, Barzegar S, Foley AJ, Mitchell JP, Cooper JA et al. The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men. Thromb Haemost 1995; 73: 82-86.
3. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1 diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
4. Stephens JW, Hurel SJ, Acharya J, Humphries SE. An interaction between the interleukin-6 -174G>C gene variant and urinary protein excretion influences plasma oxidative stress in subjects with type 2 diabetes. Cardiovasc Diabetol 2004; 3: 2.
5. Stephens JW, Hurel SJ, Cooper JA, Acharya J, Miller GJ, Humphries SE. A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. Mol Genet Metab 2004; 82: 180-186.
6. Gable DR, Stephens JW, Cooper JA, Miller GJ, Humphries SE. Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men. Diabetes 2006; 55: 1504-1511.
7. Hamon SC, Kardia SL, Boerwinkle E, Liu K, Klos KL, Clark AG et al. Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster. Hum Hered 2006; 61: 87-96.
8. Corella D, Ordovas JM. Single nucleotide polymorphisms that influence lipid metabolism: interaction with dietary factors. Ann Rev Nutr 2005; 25: 341-390.
9. Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF et al. A variant of the gene oncoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet 2006; 38: 68-74.