Endocytosis of DNA-Hsp65 Alters the pH of the late endosome/lysosome and interferes with antigen presentation

PLoS ONE

Volumn 2, Issue 9, 2007, Pages

  Trombone, Ana Paula F ^a   Silva, Célio L ^a   Lima, Karla M ^a   Oliver, Constance ^a   Jamur, Maria Célia ^a   Prescott, Alan R ^b   Coelho Castelo, Arlete A M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CLATHRIN; DNA VACCINE; HEAT SHOCK PROTEIN 65; KEYHOLE LIMPET HEMOCYANIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PLASMID DNA; RAB PROTEIN; TOLL LIKE RECEPTOR 9; BACTERIAL PROTEIN; CHAPERONIN; COMPLEMENTARY DNA; HEAT SHOCK PROTEIN 65, MYCOBACTERIUM; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM; HEMOCYANIN; KEYHOLE-LIMPET HEMOCYANIN; TLR9 PROTEIN, MOUSE; TRANSFERRIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL FATE; CELL TRANSPORT; CELL VACUOLE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; ENDOSOME; EUKARYOTIC CELL; EXPERIMENTAL MODEL; HUMORAL IMMUNITY; IMMUNOREGULATION; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; ANIMAL; CELL LINE; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PLASMID; TRANSPORT AT THE CELLULAR LEVEL;

EUKARYOTA;

ANIMALS; ANTIGEN PRESENTATION; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CELL LINE; CHAPERONINS; CLATHRIN; DNA, COMPLEMENTARY; ENDOCYTOSIS; ENDOSOMES; HEMOCYANIN; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PLASMIDS; TOLL-LIKE RECEPTOR 9; TRANSFERRIN;

EID: 41549164377     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000923     Document Type: Article

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