메뉴 건너뛰기




Volumn 8, Issue 6, 2008, Pages 1292-1301

Neurochemical dementia diagnostics: State of the art and research perspectives

Author keywords

Alzheimer's disease; Amyloid cerebrospinal fluid; Dementia; Tau

Indexed keywords

AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; TAU PROTEIN;

EID: 41549142204     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200700703     Document Type: Review
Times cited : (61)

References (91)
  • 1
    • 0032030921 scopus 로고    scopus 로고
    • Evaluation and use of diagnostic tests in Alzheimer's disease
    • Mayeux, R., Evaluation and use of diagnostic tests in Alzheimer's disease. Neurobiol. Aging 1998, 19, 139-143.
    • (1998) Neurobiol. Aging , vol.19 , pp. 139-143
    • Mayeux, R.1
  • 2
    • 0035468904 scopus 로고    scopus 로고
    • Pharmacotheraphy for Alzheimer's disease
    • Knopman, D., Pharmacotheraphy for Alzheimer's disease. Curr. Neurol. Neurosci. Rep. 2001, 1, 428-434.
    • (2001) Curr. Neurol. Neurosci. Rep , vol.1 , pp. 428-434
    • Knopman, D.1
  • 3
    • 0036162905 scopus 로고    scopus 로고
    • New drugs for Alzheimer's disease and other dementias
    • Bullock, R., New drugs for Alzheimer's disease and other dementias. Br. J. Psychiatry 2002, 180, 135-139.
    • (2002) Br. J. Psychiatry , vol.180 , pp. 135-139
    • Bullock, R.1
  • 4
    • 33750582961 scopus 로고    scopus 로고
    • Therapeutic approaches to Alzheimer's disease
    • Klafki, H. W., Staufenbiel, M., Kornhuber, J., Wiltfang, J., Therapeutic approaches to Alzheimer's disease. Brain 2006, 129, 2840-2855.
    • (2006) Brain , vol.129 , pp. 2840-2855
    • Klafki, H.W.1    Staufenbiel, M.2    Kornhuber, J.3    Wiltfang, J.4
  • 5
    • 0035921150 scopus 로고    scopus 로고
    • Dynamics of brain-derived proteins in cerebrospinal fluid
    • Reiber, H., Dynamics of brain-derived proteins in cerebrospinal fluid. Clin. Chim. Acta 2001, 310, 173-186.
    • (2001) Clin. Chim. Acta , vol.310 , pp. 173-186
    • Reiber, H.1
  • 6
    • 0035108753 scopus 로고    scopus 로고
    • Evaluation of CSF-tau and CSF-Ab42 as diagnostic markers for Alzheimer disease in clinical practice
    • Andreasen, N., Minthon, L., Davidsson, P., Vanmechelen, E. et al., Evaluation of CSF-tau and CSF-Ab42 as diagnostic markers for Alzheimer disease in clinical practice. Arch. Neurol. 2001, 58, 373-379.
    • (2001) Arch. Neurol , vol.58 , pp. 373-379
    • Andreasen, N.1    Minthon, L.2    Davidsson, P.3    Vanmechelen, E.4
  • 7
    • 0027373325 scopus 로고
    • Low frequency of post-lumbar puncture headache in demented patients
    • Blennow, K., Wallin, A., Hager, O., Low frequency of post-lumbar puncture headache in demented patients. Acta Neurol. Scand. 1993, 88, 221-223.
    • (1993) Acta Neurol. Scand , vol.88 , pp. 221-223
    • Blennow, K.1    Wallin, A.2    Hager, O.3
  • 8
    • 0032033832 scopus 로고    scopus 로고
    • Molecular and Biochemical Markers of Alzheimer's Disease, Consensus report of the Working Group on: Molecular and Biochemical Markers of Alzheimer's Disease. The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group
    • The Working Group on
    • The Working Group on: Molecular and Biochemical Markers of Alzheimer's Disease, Consensus report of the Working Group on: Molecular and Biochemical Markers of Alzheimer's Disease. The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol. Aging 1998, 19, 109-116.
    • (1998) Neurobiol. Aging , vol.19 , pp. 109-116
  • 9
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M. et al., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325, 733-736.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4
  • 10
    • 0031443264 scopus 로고    scopus 로고
    • The amyloid precursor protein gene: A neuropeptide gene with diverse functions in the central nervous system
    • Panegyres, P. K., The amyloid precursor protein gene: A neuropeptide gene with diverse functions in the central nervous system. Neuropeptides 1997, 31, 523-535.
    • (1997) Neuropeptides , vol.31 , pp. 523-535
    • Panegyres, P.K.1
  • 11
    • 0029905596 scopus 로고    scopus 로고
    • The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities
    • Klafki, H., Abramowski, D., Swoboda, R., Paganetti, P. A. et al., The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities. J. Biol. Chem. 1996, 271, 28655-28659.
    • (1996) J. Biol. Chem , vol.271 , pp. 28655-28659
    • Klafki, H.1    Abramowski, D.2    Swoboda, R.3    Paganetti, P.A.4
  • 12
    • 0029803744 scopus 로고    scopus 로고
    • Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities
    • Citron, M., Diehl, T. S., Gordon, G., Biere, A. L. et al., Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc. Natl. Acad. Sci. USA 1996, 93, 13170-13175.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13170-13175
    • Citron, M.1    Diehl, T.S.2    Gordon, G.3    Biere, A.L.4
  • 13
    • 0037022360 scopus 로고    scopus 로고
    • The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain
    • Lichtenthaler, S. F., Beher, D., Grimm, H. S., Wang, R. et al., The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc. Natl. Acad. Sci. USA 2002, 99, 1365-1370.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1365-1370
    • Lichtenthaler, S.F.1    Beher, D.2    Grimm, H.S.3    Wang, R.4
  • 14
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H., Braak, E., Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl) 1991, 82, 239-259.
    • (1991) Acta Neuropathol. (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 15
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D., Barbour, R., Dunn, W., Gordon, G. et al., Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400, 173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4
  • 16
    • 0038100154 scopus 로고    scopus 로고
    • Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    • Hock, C., Konietzko, U., Streffer, J. R., Tracy, J. et al., Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003, 38, 547-554.
    • (2003) Neuron , vol.38 , pp. 547-554
    • Hock, C.1    Konietzko, U.2    Streffer, J.R.3    Tracy, J.4
  • 17
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll, J. A., Wilkinson, D., Holmes, C., Steart, P. et al., Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report. Nat. Med. 2003, 9, 448-452.
    • (2003) Nat. Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4
  • 18
    • 10744229989 scopus 로고    scopus 로고
    • Neurochemical diagnosis of Alzheimer's dementia by CSF Ab42, Ab42/Ab40 ratio and total tau
    • Lewczuk, P., Esselmann, H., Otto, M., Maler, J. M. et al., Neurochemical diagnosis of Alzheimer's dementia by CSF Ab42, Ab42/Ab40 ratio and total tau. Neurobiol. Aging 2004, 25, 273-281.
    • (2004) Neurobiol. Aging , vol.25 , pp. 273-281
    • Lewczuk, P.1    Esselmann, H.2    Otto, M.3    Maler, J.M.4
  • 19
    • 18444393054 scopus 로고    scopus 로고
    • Highly conserved and disease-specific patterns of carboxyterminally truncated Ab peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
    • Wiltfang, J., Esselmann, H., Bibl, M., Smirnov, A. et al., Highly conserved and disease-specific patterns of carboxyterminally truncated Ab peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation. J. Neurochem. 2002, 81, 481-496.
    • (2002) J. Neurochem , vol.81 , pp. 481-496
    • Wiltfang, J.1    Esselmann, H.2    Bibl, M.3    Smirnov, A.4
  • 20
    • 0035691112 scopus 로고    scopus 로고
    • CSF total tau, Ab42 and phosphorylated tau protein as biomarkers for Alzheimer's disease
    • Blennow, K., Vanmechelen, E., Hampel, H., CSF total tau, Ab42 and phosphorylated tau protein as biomarkers for Alzheimer's disease. Mol. Neurobiol. 2001, 24, 87-97.
    • (2001) Mol. Neurobiol , vol.24 , pp. 87-97
    • Blennow, K.1    Vanmechelen, E.2    Hampel, H.3
  • 21
    • 0035095072 scopus 로고    scopus 로고
    • Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies
    • Wiltfang, J., Esselmann, H., Maler, J. M., Bleich, S. et al., Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies. Gerontology 2001, 47, 65-71.
    • (2001) Gerontology , vol.47 , pp. 65-71
    • Wiltfang, J.1    Esselmann, H.2    Maler, J.M.3    Bleich, S.4
  • 22
    • 21244457198 scopus 로고    scopus 로고
    • Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia
    • Wiltfang, J., Lewczuk, P., Riederer, P., Grunblatt, E. et al., Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia. World J. Biol. Psychiatry 2005, 6, 69-84.
    • (2005) World J. Biol. Psychiatry , vol.6 , pp. 69-84
    • Wiltfang, J.1    Lewczuk, P.2    Riederer, P.3    Grunblatt, E.4
  • 23
    • 0028982454 scopus 로고
    • Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
    • Motter, R., Vigo-Pelfrey, C., Kholodenko, D., Barbour, R. et al., Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann. Neurol. 1995, 38, 643-648.
    • (1995) Ann. Neurol , vol.38 , pp. 643-648
    • Motter, R.1    Vigo-Pelfrey, C.2    Kholodenko, D.3    Barbour, R.4
  • 24
    • 0042845853 scopus 로고    scopus 로고
    • b-Amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    • Wiltfang, J., Esselmann, H., Smirnov, A., Bibl, M. et al., b-Amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Ann. Neurol. 2003, 54, 263-267.
    • (2003) Ann. Neurol , vol.54 , pp. 263-267
    • Wiltfang, J.1    Esselmann, H.2    Smirnov, A.3    Bibl, M.4
  • 25
    • 0035856397 scopus 로고    scopus 로고
    • Low cerebrospinal fluid b-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment
    • Sjögren, M., Gisslen, M., Vanmechelen, E., Blennow, K., Low cerebrospinal fluid b-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment. Neurosci. Lett. 2001, 314, 33-36.
    • (2001) Neurosci. Lett , vol.314 , pp. 33-36
    • Sjögren, M.1    Gisslen, M.2    Vanmechelen, E.3    Blennow, K.4
  • 27
    • 15644363081 scopus 로고    scopus 로고
    • High cerebrospinal fluid tau and low amyloid b42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype
    • Galasko, D., Chang, L., Motter, R., Clark, C. M. et al., High cerebrospinal fluid tau and low amyloid b42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch. Neurol. 1998, 55, 937-945.
    • (1998) Arch. Neurol , vol.55 , pp. 937-945
    • Galasko, D.1    Chang, L.2    Motter, R.3    Clark, C.M.4
  • 28
    • 0033850407 scopus 로고    scopus 로고
    • Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
    • Buee, L., Bussiere, T., Buee-Scherrer, V., Delacourte, A. et al., Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Brain Res. Rev. 2000, 33, 95-130.
    • (2000) Brain Res. Brain Res. Rev , vol.33 , pp. 95-130
    • Buee, L.1    Bussiere, T.2    Buee-Scherrer, V.3    Delacourte, A.4
  • 29
    • 0036810492 scopus 로고    scopus 로고
    • Functions and malfunctions of the tau proteins
    • Shahani, N., Brandt, R., Functions and malfunctions of the tau proteins. Cell Mol. Life Sci. 2002, 59, 1668-1680.
    • (2002) Cell Mol. Life Sci , vol.59 , pp. 1668-1680
    • Shahani, N.1    Brandt, R.2
  • 30
    • 0028172239 scopus 로고
    • The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases
    • Mawal-Dewan, M., Henley, J., Van de Voorde, A., Trojanowski, J. Q. et al., The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J. Biol. Chem. 1994, 269, 30981-30987.
    • (1994) J. Biol. Chem , vol.269 , pp. 30981-30987
    • Mawal-Dewan, M.1    Henley, J.2    Van de Voorde, A.3    Trojanowski, J.Q.4
  • 31
    • 0029156358 scopus 로고
    • Developmental expression of tau proteins in the chicken and rat brain: Rapid down-regulation of a paired helical filament epitope in the rat cerebral cortex coincides with the transition from immature to adult tau isoforms
    • Rosner, H., Rebhan, M., Vacun, G., Vanmechelen, E., Developmental expression of tau proteins in the chicken and rat brain: Rapid down-regulation of a paired helical filament epitope in the rat cerebral cortex coincides with the transition from immature to adult tau isoforms. Int. J. Dev. Neurosci. 1995, 13, 607-617.
    • (1995) Int. J. Dev. Neurosci , vol.13 , pp. 607-617
    • Rosner, H.1    Rebhan, M.2    Vacun, G.3    Vanmechelen, E.4
  • 32
    • 0037514257 scopus 로고    scopus 로고
    • Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease
    • Sunderland, T., Linker, G., Mirza, N., Putnam, K. T. et al., Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA 2003, 289, 2094-2103.
    • (2003) JAMA , vol.289 , pp. 2094-2103
    • Sunderland, T.1    Linker, G.2    Mirza, N.3    Putnam, K.T.4
  • 33
    • 0030934518 scopus 로고    scopus 로고
    • Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    • Otto, M., Wiltfang, J., Tumani, H., Zerr, I. et al., Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurosci. Lett. 1997, 225, 210-212.
    • (1997) Neurosci. Lett , vol.225 , pp. 210-212
    • Otto, M.1    Wiltfang, J.2    Tumani, H.3    Zerr, I.4
  • 34
    • 0035910638 scopus 로고    scopus 로고
    • Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke
    • Hesse, C., Rosengren, L., Andreasen, N., Davidsson, P. et al., Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke. Neurosci. Lett. 2001, 297, 187-190.
    • (2001) Neurosci. Lett , vol.297 , pp. 187-190
    • Hesse, C.1    Rosengren, L.2    Andreasen, N.3    Davidsson, P.4
  • 35
    • 0022550260 scopus 로고
    • Defective brain microtubule assembly in Alzheimer's disease
    • Iqbal, K., Grundke-Iqbal, I., Zaidi, T., Merz, P. A. et al., Defective brain microtubule assembly in Alzheimer's disease. Lancet 1986, 2, 421-426.
    • (1986) Lancet , vol.2 , pp. 421-426
    • Iqbal, K.1    Grundke-Iqbal, I.2    Zaidi, T.3    Merz, P.A.4
  • 36
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M. et al., Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA 1986, 83, 4913-4917.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4
  • 37
    • 0036107977 scopus 로고    scopus 로고
    • Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : An ultra-sensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay
    • Hu, Y. Y., He, S. S., Wang, X., Duan, Q. H. et al., Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : An ultra-sensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. Am. J. Pathol. 2002, 160, 1269-1278.
    • (2002) Am. J. Pathol , vol.160 , pp. 1269-1278
    • Hu, Y.Y.1    He, S.S.2    Wang, X.3    Duan, Q.H.4
  • 38
    • 18544370897 scopus 로고    scopus 로고
    • Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
    • Iqbal, K., Alonso Adel, C., El-Akkad, E., Gong, C. X. et al., Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion. J. Mol. Neurosci. 2002, 19, 95-99.
    • (2002) J. Mol. Neurosci , vol.19 , pp. 95-99
    • Iqbal, K.1    Alonso Adel, C.2    El-Akkad, E.3    Gong, C.X.4
  • 39
    • 4344626089 scopus 로고    scopus 로고
    • Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in alzheimer's disease: Original data and review of the literature
    • Lewczuk, P., Esselmann, H., Bibl, M., Beck, G. et al., Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in alzheimer's disease: Original data and review of the literature. J. Mol. Neurosci. 2004, 23, 115-122.
    • (2004) J. Mol. Neurosci , vol.23 , pp. 115-122
    • Lewczuk, P.1    Esselmann, H.2    Bibl, M.3    Beck, G.4
  • 41
    • 0035261534 scopus 로고    scopus 로고
    • CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group
    • Parnetti, L., Lanari, A., Amici, S., Gallai, V. et al., CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group. Neurol. Sci. 2001, 22, 77-78.
    • (2001) Neurol. Sci , vol.22 , pp. 77-78
    • Parnetti, L.1    Lanari, A.2    Amici, S.3    Gallai, V.4
  • 42
    • 0034899223 scopus 로고    scopus 로고
    • Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease
    • Itoh, N., Arai, H., Urakami, K., Ishiguro, K. et al., Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease. Ann. Neurol. 2001, 50, 150-156.
    • (2001) Ann. Neurol , vol.50 , pp. 150-156
    • Itoh, N.1    Arai, H.2    Urakami, K.3    Ishiguro, K.4
  • 43
    • 0035066999 scopus 로고    scopus 로고
    • Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231
    • Hampel, H., Buerger, K., Kohnken, R., Teipel, S. J. et al., Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann. Neurol. 2001, 49, 545-546.
    • (2001) Ann. Neurol , vol.49 , pp. 545-546
    • Hampel, H.1    Buerger, K.2    Kohnken, R.3    Teipel, S.J.4
  • 44
    • 0033762113 scopus 로고    scopus 로고
    • A prospective study
    • CSF phosphorylated tau protein and mild cognitive impairment
    • Arai, H., Ishiguro, K., Ohno, H., Moriyama, M. et al., CSF phosphorylated tau protein and mild cognitive impairment: A prospective study. Exp. Neurol. 2000, 166, 201-203.
    • (2000) Exp. Neurol , vol.166 , pp. 201-203
    • Arai, H.1    Ishiguro, K.2    Ohno, H.3    Moriyama, M.4
  • 45
    • 9144257234 scopus 로고    scopus 로고
    • Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: A comparative cerebrospinal fluid study
    • Hampel, H., Buerger, K., Zinkowski, R., Teipel, S. J. et al., Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: A comparative cerebrospinal fluid study. Arch. Gen. Psychiatry 2004, 61, 95-102.
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 95-102
    • Hampel, H.1    Buerger, K.2    Zinkowski, R.3    Teipel, S.J.4
  • 46
    • 0033813526 scopus 로고    scopus 로고
    • Genetic and biochemical markers for Alzheimer's disease: Recent developments
    • Mulder, C., Scheltens, P., Visser, J. J., van Kamp, G. J. et al., Genetic and biochemical markers for Alzheimer's disease: Recent developments. Ann. Clin. Biochem. 2000, 37, 593-607.
    • (2000) Ann. Clin. Biochem , vol.37 , pp. 593-607
    • Mulder, C.1    Scheltens, P.2    Visser, J.J.3    van Kamp, G.J.4
  • 47
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M. et al., Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993, 90, 1977-1981.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3    Pericak-Vance, M.4
  • 48
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B. et al., Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997, 278, 1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4
  • 49
    • 0032545939 scopus 로고    scopus 로고
    • Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease
    • Mayeux, R., Saunders, A. M., Shea, S., Mirra, S. et al., Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N. Engl. J. Med. 1998, 338, 506-511.
    • (1998) N. Engl. J. Med , vol.338 , pp. 506-511
    • Mayeux, R.1    Saunders, A.M.2    Shea, S.3    Mirra, S.4
  • 50
    • 0028850301 scopus 로고
    • Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis
    • Tumani, H., Nolker, G., Reiber, H., Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis. Neurology 1995, 45, 1663-1670.
    • (1995) Neurology , vol.45 , pp. 1663-1670
    • Tumani, H.1    Nolker, G.2    Reiber, H.3
  • 51
    • 0031663125 scopus 로고    scopus 로고
    • The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis
    • Reiber, H., Ungefehr, S., Jacobi, C., The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult. Scler. 1998, 4, 111-117.
    • (1998) Mult. Scler , vol.4 , pp. 111-117
    • Reiber, H.1    Ungefehr, S.2    Jacobi, C.3
  • 52
    • 0035900774 scopus 로고    scopus 로고
    • Elevation of b-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    • Wiltfang, J., Esselmann, H., Cupers, P., Neumann, M. et al., Elevation of b-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. J. Biol. Chem. 2001, 276, 42645-42657.
    • (2001) J. Biol. Chem , vol.276 , pp. 42645-42657
    • Wiltfang, J.1    Esselmann, H.2    Cupers, P.3    Neumann, M.4
  • 53
    • 0029661424 scopus 로고    scopus 로고
    • Analysis of heterogeneous bA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
    • Ida, N., Hartmann, T., Pantel, J., Schröder, J. et al., Analysis of heterogeneous bA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 1996, 271, 22908-22914.
    • (1996) J. Biol. Chem , vol.271 , pp. 22908-22914
    • Ida, N.1    Hartmann, T.2    Pantel, J.3    Schröder, J.4
  • 54
    • 34247581358 scopus 로고    scopus 로고
    • Amyloid b peptide ratio 42/40 but not Ab42 correlates with phospho-Tau in patients with low- and high-CSF Ab40 load
    • Wiltfang, J., Esselmann, H., Bibl, M., Hull, M. et al., Amyloid b peptide ratio 42/40 but not Ab42 correlates with phospho-Tau in patients with low- and high-CSF Ab40 load. J. Neurochem. 2007, 101, 1053-1059.
    • (2007) J. Neurochem , vol.101 , pp. 1053-1059
    • Wiltfang, J.1    Esselmann, H.2    Bibl, M.3    Hull, M.4
  • 55
    • 4344681535 scopus 로고    scopus 로고
    • Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region
    • Lammich, S., Schobel, S., Zimmer, A. K., Lichtenthaler, S. F. et al., Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region. EMBO Rep. 2004, 5, 620-625.
    • (2004) EMBO Rep , vol.5 , pp. 620-625
    • Lammich, S.1    Schobel, S.2    Zimmer, A.K.3    Lichtenthaler, S.F.4
  • 56
    • 14444269228 scopus 로고    scopus 로고
    • Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: A study in Japan
    • Kanai, M., Matsubara, E., Isoe, K., Urakami, K. et al., Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: A study in Japan. Ann. Neurol. 1998, 44, 17-26.
    • (1998) Ann. Neurol , vol.44 , pp. 17-26
    • Kanai, M.1    Matsubara, E.2    Isoe, K.3    Urakami, K.4
  • 57
    • 2342551973 scopus 로고    scopus 로고
    • Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease
    • Schoonenboom, N. S., Pijnenburg, Y. A., Mulder, C., Rosso, S. M. et al., Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease. Neurology 2004, 62, 1580-1584.
    • (2004) Neurology , vol.62 , pp. 1580-1584
    • Schoonenboom, N.S.1    Pijnenburg, Y.A.2    Mulder, C.3    Rosso, S.M.4
  • 59
    • 0029162670 scopus 로고
    • Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease
    • Arai, H., Terajima, M., Miura, M., Higuchi, S. et al., Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease. Ann. Neurol. 1995, 38, 649-652.
    • (1995) Ann. Neurol , vol.38 , pp. 649-652
    • Arai, H.1    Terajima, M.2    Miura, M.3    Higuchi, S.4
  • 60
    • 0343471538 scopus 로고    scopus 로고
    • Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease
    • Golombowski, S., Muller-Spahn, F., Romig, H., Mendla, K. et al., Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease. Neurosci. Lett. 1997, 225, 213-215.
    • (1997) Neurosci. Lett , vol.225 , pp. 213-215
    • Golombowski, S.1    Muller-Spahn, F.2    Romig, H.3    Mendla, K.4
  • 61
    • 0030599039 scopus 로고    scopus 로고
    • Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow- up
    • Blomberg, M., Jensen, M., Basun, H., Lannfelt, L. et al., Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow- up. Neurosci. Lett. 1996, 214, 163-166.
    • (1996) Neurosci. Lett , vol.214 , pp. 163-166
    • Blomberg, M.1    Jensen, M.2    Basun, H.3    Lannfelt, L.4
  • 63
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M. et al., Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993, 90, 8098-8102.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3    Dong, L.M.4
  • 64
    • 0032693829 scopus 로고    scopus 로고
    • Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample
    • Andreasen, N., Minthon, L., Clarberg, A., Davidsson, P. et al., Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample. Neurology 1999, 53, 1488-1494.
    • (1999) Neurology , vol.53 , pp. 1488-1494
    • Andreasen, N.1    Minthon, L.2    Clarberg, A.3    Davidsson, P.4
  • 65
    • 0032988610 scopus 로고    scopus 로고
    • Mild cognitive impairment: Clinical characterization and outcome
    • Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J. et al., Mild cognitive impairment: Clinical characterization and outcome. Arch. Neurol. 1999, 56, 303-308.
    • (1999) Arch. Neurol , vol.56 , pp. 303-308
    • Petersen, R.C.1    Smith, G.E.2    Waring, S.C.3    Ivnik, R.J.4
  • 66
    • 0037244487 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment
    • Andreasen, N., Vanmechelen, E., Vanderstichele, H., Davidsson, P. et al., Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment. Acta Neurol. Scand. Suppl. 2003, 179, 47-51.
    • (2003) Acta Neurol. Scand. Suppl , vol.179 , pp. 47-51
    • Andreasen, N.1    Vanmechelen, E.2    Vanderstichele, H.3    Davidsson, P.4
  • 67
    • 0242627597 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers for prediction of Alzheimer's disease
    • Zetterberg, H., Wahlund, L. O., Blennow, K., Cerebrospinal fluid markers for prediction of Alzheimer's disease. Neurosci. Lett. 2003, 352, 67-69.
    • (2003) Neurosci. Lett , vol.352 , pp. 67-69
    • Zetterberg, H.1    Wahlund, L.O.2    Blennow, K.3
  • 68
    • 32544435900 scopus 로고    scopus 로고
    • A follow-up study
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment
    • Hansson, O., Zetterberg, H., Buchhave, P., Londos, E. et al., Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurol. 2006, 5, 228-234.
    • (2006) Lancet Neurol , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4
  • 69
    • 42649128419 scopus 로고    scopus 로고
    • A multicenter study
    • Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI:, in press
    • Lewczuk, P., Kornhuber, J., Vanderstichele, H., Vanmechelen, E. et al., Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: A multicenter study. Neurobiol. Aging 2007, in press.
    • (2007) Neurobiol. Aging
    • Lewczuk, P.1    Kornhuber, J.2    Vanderstichele, H.3    Vanmechelen, E.4
  • 70
    • 0034699375 scopus 로고    scopus 로고
    • Multiplexed particle-based flow cytometric assays
    • Vignali, D. A., Multiplexed particle-based flow cytometric assays. J. Immunol. Methods 2000, 243, 243-255.
    • (2000) J. Immunol. Methods , vol.243 , pp. 243-255
    • Vignali, D.A.1
  • 71
    • 0032856945 scopus 로고    scopus 로고
    • Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
    • Carson, R. T., Vignali, D. A., Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J. Immunol. Methods 1999, 227, 41-52.
    • (1999) J. Immunol. Methods , vol.227 , pp. 41-52
    • Carson, R.T.1    Vignali, D.A.2
  • 72
    • 12944312683 scopus 로고    scopus 로고
    • Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
    • Olsson, A., Vanderstichele, H., Andreasen, N., De Meyer, G. et al., Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin. Chem. 2005, 51, 336-345.
    • (2005) Clin. Chem , vol.51 , pp. 336-345
    • Olsson, A.1    Vanderstichele, H.2    Andreasen, N.3    De Meyer, G.4
  • 73
    • 24144443470 scopus 로고    scopus 로고
    • Amino-truncated b-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment
    • Vanderstichele, H., De Meyer, G., Andreasen, N., Kostanjevecki, V. et al., Amino-truncated b-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment. Clin. Chem. 2005, 51, 1650-1660.
    • (2005) Clin. Chem , vol.51 , pp. 1650-1660
    • Vanderstichele, H.1    De Meyer, G.2    Andreasen, N.3    Kostanjevecki, V.4
  • 74
    • 33646266021 scopus 로고    scopus 로고
    • CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
    • Bibl, M., Mollenhauer, B., Esselmann, H., Lewczuk, P. et al., CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia. Brain 2006, 129, 1177-1187.
    • (2006) Brain , vol.129 , pp. 1177-1187
    • Bibl, M.1    Mollenhauer, B.2    Esselmann, H.3    Lewczuk, P.4
  • 75
    • 34247485829 scopus 로고    scopus 로고
    • Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations
    • Bibl, M., Mollenhauer, B., Wolf, S., Esselmann, H. et al., Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations. J. Neural. Transm. 2007, 114, 621-628.
    • (2007) J. Neural. Transm , vol.114 , pp. 621-628
    • Bibl, M.1    Mollenhauer, B.2    Wolf, S.3    Esselmann, H.4
  • 76
    • 34347272662 scopus 로고    scopus 로고
    • Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    • in press
    • Bibl, M., Mollenhauer, B., Lewczuk, P., Esselmann, H. et al., Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol. Psychiatry 2007, in press.
    • (2007) Mol. Psychiatry
    • Bibl, M.1    Mollenhauer, B.2    Lewczuk, P.3    Esselmann, H.4
  • 77
    • 0031914675 scopus 로고    scopus 로고
    • Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease
    • Zerr, I., Bodemer, M., Gefeller, O., Otto, M. et al., Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Ann. Neurol. 1998, 43, 32-40.
    • (1998) Ann. Neurol , vol.43 , pp. 32-40
    • Zerr, I.1    Bodemer, M.2    Gefeller, O.3    Otto, M.4
  • 78
    • 31844443892 scopus 로고    scopus 로고
    • Effect of sample collection tubes on cerebrospinal fluid concentrations of tau proteins and amyloid b peptides
    • Lewczuk, P., Beck, G., Esselmann, H., Bruckmoser, R. et al., Effect of sample collection tubes on cerebrospinal fluid concentrations of tau proteins and amyloid b peptides. Clin. Chem. 2006, 52, 332-334.
    • (2006) Clin. Chem , vol.52 , pp. 332-334
    • Lewczuk, P.1    Beck, G.2    Esselmann, H.3    Bruckmoser, R.4
  • 79
    • 0033637408 scopus 로고    scopus 로고
    • Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma
    • Vanderstichele, H., Van Kerschaver, E., Hesse, C., Davidsson, P. et al., Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma. Amyloid 2000, 7, 245-258.
    • (2000) Amyloid , vol.7 , pp. 245-258
    • Vanderstichele, H.1    Van Kerschaver, E.2    Hesse, C.3    Davidsson, P.4
  • 80
    • 33746049439 scopus 로고    scopus 로고
    • The German Competence Net Dementias: Standard operating procedures for the neurochemical dementia diagnostics
    • Lewczuk, P., Kornhuber, J., Wiltfang, J., The German Competence Net Dementias: Standard operating procedures for the neurochemical dementia diagnostics. J. Neural. Transm. 2006, 113, 1075-1080.
    • (2006) J. Neural. Transm , vol.113 , pp. 1075-1080
    • Lewczuk, P.1    Kornhuber, J.2    Wiltfang, J.3
  • 81
    • 33750975073 scopus 로고    scopus 로고
    • International quality control survey of neurochemical dementia diagnostics
    • Lewczuk, P., Beck, G., Ganslandt, O., Esselmann, H. et al., International quality control survey of neurochemical dementia diagnostics. Neurosci. Lett. 2006, 409, 1-4.
    • (2006) Neurosci. Lett , vol.409 , pp. 1-4
    • Lewczuk, P.1    Beck, G.2    Ganslandt, O.3    Esselmann, H.4
  • 83
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Ab antibody alters CNS and plasma Ab clearance and decreases brain Ab burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C. et al., Peripheral anti-Ab antibody alters CNS and plasma Ab clearance and decreases brain Ab burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2001, 98, 8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4
  • 84
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-b efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. et al., Brain to plasma amyloid-b efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 2002, 295, 2264-2267.
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4
  • 85
    • 0037385370 scopus 로고    scopus 로고
    • Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: Defining the perivascular route for the elimination of amyloid beta from the human brain
    • Preston, S. D., Steart, P. V., Wilkinson, A., Nicoll, J. A. et al., Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: Defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol. Appl. Neurobiol. 2003, 29, 106-117.
    • (2003) Neuropathol. Appl. Neurobiol , vol.29 , pp. 106-117
    • Preston, S.D.1    Steart, P.V.2    Wilkinson, A.3    Nicoll, J.A.4
  • 86
    • 0031721665 scopus 로고    scopus 로고
    • Differential level of platelet amyloid b precursor protein isoforms: An early marker for Alzheimer disease
    • Di Luca, M., Pastorino, L., Bianchetti, A., Perez, J. et al., Differential level of platelet amyloid b precursor protein isoforms: An early marker for Alzheimer disease. Arch. Neurol. 1998, 55, 1195-1200.
    • (1998) Arch. Neurol , vol.55 , pp. 1195-1200
    • Di Luca, M.1    Pastorino, L.2    Bianchetti, A.3    Perez, J.4
  • 87
    • 0033622195 scopus 로고    scopus 로고
    • Elevated Ab42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbPP metabolism
    • Kuo, Y. M., Kokjohn, T. A., Watson, M. D., Woods, A. S. et al., Elevated Ab42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbPP metabolism. Am. J. Pathol. 2000, 156, 797-805.
    • (2000) Am. J. Pathol , vol.156 , pp. 797-805
    • Kuo, Y.M.1    Kokjohn, T.A.2    Watson, M.D.3    Woods, A.S.4
  • 88
    • 9144271212 scopus 로고    scopus 로고
    • Electrophoretic separation of amyloid beta peptides in plasma
    • Lewczuk, P., Esselmann, H., Bibl, M., Paul, S. et al., Electrophoretic separation of amyloid beta peptides in plasma. Electrophoresis 2004, 25, 3336-3343.
    • (2004) Electrophoresis , vol.25 , pp. 3336-3343
    • Lewczuk, P.1    Esselmann, H.2    Bibl, M.3    Paul, S.4
  • 89
    • 33947282076 scopus 로고    scopus 로고
    • Association of low plasma abeta42/abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease
    • Graff-Radford, N. R., Crook, J. E., Lucas, J., Boeve, B. F. et al., Association of low plasma abeta42/abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Arch. Neurol. 2007, 64, 354-362.
    • (2007) Arch. Neurol , vol.64 , pp. 354-362
    • Graff-Radford, N.R.1    Crook, J.E.2    Lucas, J.3    Boeve, B.F.4
  • 90
    • 33745959062 scopus 로고    scopus 로고
    • Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: A prospective case-cohort study
    • van Oijen, M., Hofman, A., Soares, H. D., Koudstaal, P. J. et al., Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: A prospective case-cohort study. Lancet Neurol. 2006, 5, 655-660.
    • (2006) Lancet Neurol , vol.5 , pp. 655-660
    • van Oijen, M.1    Hofman, A.2    Soares, H.D.3    Koudstaal, P.J.4
  • 91
    • 0242412140 scopus 로고    scopus 로고
    • Plasma Ab40 and Ab42 and Alzheimer's disease: Relation to age, mortality, and risk
    • Mayeux, R., Honig, L. S., Tang, M. X., Manly, J. et al., Plasma Ab40 and Ab42 and Alzheimer's disease: Relation to age, mortality, and risk. Neurology 2003, 61, 1185-1190.
    • (2003) Neurology , vol.61 , pp. 1185-1190
    • Mayeux, R.1    Honig, L.S.2    Tang, M.X.3    Manly, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.