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Volumn 83, Issue 4, 2008, Pages 397-407

Mesenchymal stem cells in tissue engineering

Author keywords

Differentiation; Mesenchymal stem cell; MSC; TE; Tissue engineering

Indexed keywords

CELLS; DIFFERENTIATION (CALCULUS); DRUG THERAPY;

EID: 41549098692     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.1901     Document Type: Short Survey
Times cited : (14)

References (132)
  • 1
    • 0346365434 scopus 로고    scopus 로고
    • Current status of liver transplantation in children
    • McDiarmid SV, Current status of liver transplantation in children. Pediatr Clin North Am 50:1335-1374 (2003).
    • (2003) Pediatr Clin North Am , vol.50 , pp. 1335-1374
    • McDiarmid, S.V.1
  • 2
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R and Vacanti JP, Tissue engineering. Science 260:920-9266 (1993).
    • (1993) Science , vol.260 , pp. 920-9266
    • Langer, R.1    Vacanti, J.P.2
  • 4
    • 18244366662 scopus 로고    scopus 로고
    • Tissue engineering- current challenges and expanding opportunities
    • Griffith LG and Naughton G, Tissue engineering- current challenges and expanding opportunities. Science 295:1009-1014 (2002).
    • (2002) Science , vol.295 , pp. 1009-1014
    • Griffith, L.G.1    Naughton, G.2
  • 5
    • 33845921327 scopus 로고    scopus 로고
    • Tissue engineering and developmental biology: Going biomimetic
    • Ingber DE, et al, Tissue engineering and developmental biology: going biomimetic. Tissue Eng 12:3265-3283 (2006).
    • (2006) Tissue Eng , vol.12 , pp. 3265-3283
    • Ingber, D.E.1
  • 6
    • 0035499350 scopus 로고    scopus 로고
    • Stem cells in tissue engineering
    • Bianco P and Robey PG, Stem cells in tissue engineering. Nature 414:118-121 (2001).
    • (2001) Nature , vol.414 , pp. 118-121
    • Bianco, P.1    Robey, P.G.2
  • 7
    • 0141890186 scopus 로고    scopus 로고
    • Biology and clinical applications of mesenchymal stem cells
    • Barry FP, Biology and clinical applications of mesenchymal stem cells. Birth Defects Res Part C Embryo Today 69:250-256 (2003).
    • (2003) Birth Defects Res Part C Embryo Today , vol.69 , pp. 250-256
    • Barry, F.P.1
  • 8
    • 0035498850 scopus 로고    scopus 로고
    • The end of the beginning for pluripotent stem cells
    • Donovan PJ and Gearhart J, The end of the beginning for pluripotent stem cells. Nature 414:92-97 (2001).
    • (2001) Nature , vol.414 , pp. 92-97
    • Donovan, P.J.1    Gearhart, J.2
  • 9
    • 28144434353 scopus 로고    scopus 로고
    • Mesenchymal stem cells
    • Vaananen HK, Mesenchymal stem cells. Ann Med 37:469-479 (2005).
    • (2005) Ann Med , vol.37 , pp. 469-479
    • Vaananen, H.K.1
  • 10
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L, Chagastelles PC and Nardi NB, Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119:2204-2213 (2006).
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 11
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, et al, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363:1439-1441 (2004).
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1
  • 12
    • 84984766699 scopus 로고    scopus 로고
    • A glossary for stem-cell biology
    • Smith A, A glossary for stem-cell biology. Nature 441:1060 (2006).
    • (2006) Nature , vol.441 , pp. 1060
    • Smith, A.1
  • 13
    • 0035479836 scopus 로고    scopus 로고
    • Differentiation potential of adult stem cells
    • Clarke D and Frisen J, Differentiation potential of adult stem cells. Curr Opin Genet Dev 11:575-580 (2001).
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 575-580
    • Clarke, D.1    Frisen, J.2
  • 14
    • 0032874061 scopus 로고    scopus 로고
    • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
    • Kopen GC, Prockop DJ and Phinney DG, Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96:10711-10716 (1999).
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10711-10716
    • Kopen, G.C.1    Prockop, D.J.2    Phinney, D.G.3
  • 15
    • 22144460191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion
    • Sato Y, et al, Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 106:756-763 (2005).
    • (2005) Blood , vol.106 , pp. 756-763
    • Sato, Y.1
  • 17
    • 0035889146 scopus 로고    scopus 로고
    • Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    • Campagnoli C, et al, Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98:2396-2402 (2001).
    • (2001) Blood , vol.98 , pp. 2396-2402
    • Campagnoli, C.1
  • 19
    • 3543003475 scopus 로고    scopus 로고
    • Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood
    • Bieback K, et al, Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 22:625-634 (2004).
    • (2004) Stem Cells , vol.22 , pp. 625-634
    • Bieback, K.1
  • 20
    • 10444248938 scopus 로고    scopus 로고
    • Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    • Wang HS, et al, Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 22:1330-1337 (2004).
    • (2004) Stem Cells , vol.22 , pp. 1330-1337
    • Wang, H.S.1
  • 22
    • 20444429578 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy
    • Baksh D, Song L and Tuan RS, Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8:301-316 (2004).
    • (2004) J Cell Mol Med , vol.8 , pp. 301-316
    • Baksh, D.1    Song, L.2    Tuan, R.S.3
  • 23
    • 0033917320 scopus 로고    scopus 로고
    • Marrow stromal stem cells
    • Bianco P and Gehron Robey P, Marrow stromal stem cells. J Clin Invest 105: 1663-1668 (2000).
    • (2000) J Clin Invest , vol.105 , pp. 1663-1668
    • Bianco, P.1    Gehron Robey, P.2
  • 24
    • 2442464824 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Paradoxes of passaging
    • Javazon EH, Beggs KJ and Flake AW, Mesenchymal stem cells: paradoxes of passaging. Exp Hematol 32:414-425 (2004).
    • (2004) Exp Hematol , vol.32 , pp. 414-425
    • Javazon, E.H.1    Beggs, K.J.2    Flake, A.W.3
  • 25
    • 0034975453 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century
    • Caplan AI and Bruder SP, Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7:259-264 (2001).
    • (2001) Trends Mol Med , vol.7 , pp. 259-264
    • Caplan, A.I.1    Bruder, S.P.2
  • 27
    • 1542269027 scopus 로고    scopus 로고
    • Circulating mesenchymal stem cells
    • Roufosse CA, et al, Circulating mesenchymal stem cells. Int J Biochem Cell Biol 36:585-597 (2004).
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 585-597
    • Roufosse, C.A.1
  • 28
    • 0035109569 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Heading into the clinic
    • Koc ON and Lazarus HM, Mesenchymal stem cells: heading into the clinic. Bone Marrow Transplant 27:235-239 (2001).
    • (2001) Bone Marrow Transplant , vol.27 , pp. 235-239
    • Koc, O.N.1    Lazarus, H.M.2
  • 29
    • 0034244385 scopus 로고    scopus 로고
    • Biology and clinical utilization of mesenchymal progenitor cells
    • Minguell JJ, Conget P and Erices A, Biology and clinical utilization of mesenchymal progenitor cells. Braz J Med Biol Res 33:881-887 (2000).
    • (2000) Braz J Med Biol Res , vol.33 , pp. 881-887
    • Minguell, J.J.1    Conget, P.2    Erices, A.3
  • 31
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI, Mesenchymal stem cells. J Orthop Res 9:641-650 (1991).
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 32
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK and Lalykina KS, The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393-403 (1970).
    • (1970) Cell Tissue Kinet , vol.3 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 33
    • 0018947660 scopus 로고
    • Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
    • Castro-Malaspina H, et al, Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 56:289-301 (1980).
    • (1980) Blood , vol.56 , pp. 289-301
    • Castro-Malaspina, H.1
  • 34
    • 0024252149 scopus 로고
    • Stromal stem cells: Marrow-derived osteogenic precursors
    • Owen M and Friedenstein AJ, Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 136:42-60 (1988).
    • (1988) Ciba Found Symp , vol.136 , pp. 42-60
    • Owen, M.1    Friedenstein, A.J.2
  • 35
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison SJ and Kimble J, Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441:1068-1074 (2006).
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 36
    • 0035727706 scopus 로고    scopus 로고
    • Microenvironment and stem properties of bone marrow-derived mesenchymal cells
    • Bianchi G, et al, Microenvironment and stem properties of bone marrow-derived mesenchymal cells. Wound Repair Rege, 9:460-406 (2001).
    • (2001) Wound Repair Rege , vol.9 , pp. 460-406
    • Bianchi, G.1
  • 37
    • 27944445760 scopus 로고    scopus 로고
    • Mesenchymal stem cell aging
    • Fehrer C and Lepperdinger G, Mesenchymal stem cell aging. Exp Gerontol 40:926-930 (2005).
    • (2005) Exp Gerontol , vol.40 , pp. 926-930
    • Fehrer, C.1    Lepperdinger, G.2
  • 38
    • 0842330317 scopus 로고    scopus 로고
    • Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes
    • Parsch D, et al, Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes. J Mol Med 82:49-55 (2004).
    • (2004) J Mol Med , vol.82 , pp. 49-55
    • Parsch, D.1
  • 39
    • 0038717085 scopus 로고    scopus 로고
    • Lack of telomerase activity in human mesenchymal stem cells
    • Zimmermann S, et al, Lack of telomerase activity in human mesenchymal stem cells. Leukemia 17:1146-1149 (2003).
    • (2003) Leukemia , vol.17 , pp. 1146-1149
    • Zimmermann, S.1
  • 40
    • 4444273090 scopus 로고    scopus 로고
    • Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion
    • Baxter MA, et al, Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22:675-682 (2004).
    • (2004) Stem Cells , vol.22 , pp. 675-682
    • Baxter, M.A.1
  • 41
    • 1542286220 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Clinical applications and biological characterization
    • Barry FP and Murphy JM, Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 36:568-584 (2004).
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 568-584
    • Barry, F.P.1    Murphy, J.M.2
  • 42
    • 0035450718 scopus 로고    scopus 로고
    • Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors
    • Young HE, et al, Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec 264:51-62 (2001).
    • (2001) Anat Rec , vol.264 , pp. 51-62
    • Young, H.E.1
  • 43
    • 0034468279 scopus 로고    scopus 로고
    • Mesenchymal precursor cells in the blood of normal individuals
    • Zvaifler NJ, et al, Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res 2:477-488 (2002).
    • (2002) Arthritis Res , vol.2 , pp. 477-488
    • Zvaifler, N.J.1
  • 44
    • 33845983611 scopus 로고    scopus 로고
    • Concise review: Multipotent mesenchymal stromal cells in blood
    • He Q, Wan C and Li G, Concise review: multipotent mesenchymal stromal cells in blood. Stem Cells 25:69-77 (2007).
    • (2007) Stem Cells , vol.25 , pp. 69-77
    • He, Q.1    Wan, C.2    Li, G.3
  • 45
    • 33646015065 scopus 로고    scopus 로고
    • The role of mesenchymal stem cells in haemopoiesis
    • Dazzi F, et al, The role of mesenchymal stem cells in haemopoiesis. Blood Rev 20:161-71 (2006).
    • (2006) Blood Rev , vol.20 , pp. 161-171
    • Dazzi, F.1
  • 46
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R, The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4:7-25 (1978).
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 47
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden DT, The stem-cell niche as an entity of action. Nature 441:1075-1079 (2006).
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 48
    • 34247587041 scopus 로고    scopus 로고
    • Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: Regulation of niche, self-renewal and differentiation
    • Kolf CM, Cho E and Tuan RS, Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 9:204 (2007).
    • (2007) Arthritis Res Ther , vol.9 , pp. 204
    • Kolf, C.M.1    Cho, E.2    Tuan, R.S.3
  • 49
    • 0024147344 scopus 로고
    • Marrow stromal stem cells
    • Owen M, Marrow stromal stem cells. J Cell Sci 10:suppl: 63-76 (1988).
    • (1988) J Cell Sci , vol.10 , Issue.SUPPL. , pp. 63-76
    • Owen, M.1
  • 50
    • 0033824164 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biology and potential clinical uses
    • Deans RJ and Moseley AB, Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 28:875-884 (2000).
    • (2000) Exp Hematol , vol.28 , pp. 875-884
    • Deans, R.J.1    Moseley, A.B.2
  • 51
    • 20444454865 scopus 로고    scopus 로고
    • Role of adult mesenchymal stem cells in bone tissue engineering applications: Current status and future prospects
    • Mauney JR, Volloch V and Kaplan DL, Role of adult mesenchymal stem cells in bone tissue engineering applications: current status and future prospects. Tissue Eng 11:787-802 (2005).
    • (2005) Tissue Eng , vol.11 , pp. 787-802
    • Mauney, J.R.1    Volloch, V.2    Kaplan, D.L.3
  • 52
    • 0034988303 scopus 로고    scopus 로고
    • Bone marrow stromal stem cells: Nature, biology, and potential applications
    • Bianco P, et al, Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180-192 (2001).
    • (2001) Stem Cells , vol.19 , pp. 180-192
    • Bianco, P.1
  • 53
    • 0347004678 scopus 로고    scopus 로고
    • Mesenchymal stem cells
    • Short B, et al, Mesenchymal stem cells. Arch Med Res 34:565-571 (2003).
    • (2003) Arch Med Res , vol.34 , pp. 565-571
    • Short, B.1
  • 54
    • 0035137944 scopus 로고    scopus 로고
    • Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix
    • Gronthos S, et al, Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28:174-181 (2001).
    • (2001) Bone , vol.28 , pp. 174-181
    • Gronthos, S.1
  • 55
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • Jaiswal N, et al, Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64:295-312 (1997).
    • (1997) J Cell Biochem , vol.64 , pp. 295-312
    • Jaiswal, N.1
  • 56
    • 0031817577 scopus 로고    scopus 로고
    • In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    • Johnstone B, et al, In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238:265-272 (1998).
    • (1998) Exp Cell Res , vol.238 , pp. 265-272
    • Johnstone, B.1
  • 57
    • 0032425950 scopus 로고    scopus 로고
    • The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells
    • Yoo JU, et al, The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg Am 80:1745-1757 (1998).
    • (1998) J Bone Joint Surg Am , vol.80 , pp. 1745-1757
    • Yoo, J.U.1
  • 58
    • 0025865559 scopus 로고
    • Adipocytic cells cultured from marrow have osteogenic potential
    • Bennett JH, et al, Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci 99:131-139 (1991).
    • (1991) J Cell Sci , vol.99 , pp. 131-139
    • Bennett, J.H.1
  • 59
    • 0036651815 scopus 로고    scopus 로고
    • Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures
    • Justesen J, et al, Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int 71:36-44 (2002).
    • (2002) Calcif Tissue Int , vol.71 , pp. 36-44
    • Justesen, J.1
  • 60
    • 0032924683 scopus 로고    scopus 로고
    • Interconversion potential of cloned human marrow adipocytes in vitro
    • Park SR, Oreffo RO and Triffitt JT, Interconversion potential of cloned human marrow adipocytes in vitro. Bone 24:549-554 (1999).
    • (1999) Bone , vol.24 , pp. 549-554
    • Park, S.R.1    Oreffo, R.O.2    Triffitt, J.T.3
  • 61
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, et al, Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147 (1999).
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1
  • 63
    • 33847632532 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Molecular targets for tissue engineering
    • Satija NK, et al, Mesenchymal stem cells: molecular targets for tissue engineering. Stem Cells Dev 16:7-23 (2007).
    • (2007) Stem Cells Dev , vol.16 , pp. 7-23
    • Satija, N.K.1
  • 64
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, et al, Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-49 (2002).
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1
  • 65
    • 0036417287 scopus 로고    scopus 로고
    • Inducing cellular dedifferentiation: A potential method for enhancing endogenous regeneration in mammals
    • Odelberg SJ, Inducing cellular dedifferentiation: a potential method for enhancing endogenous regeneration in mammals. Semin Cell Dev Biol 13:335-343 (2002).
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 335-343
    • Odelberg, S.J.1
  • 66
    • 33751411142 scopus 로고    scopus 로고
    • Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages
    • Zhao W, et al, Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages. Biochem Biophys Res Commun 352:84-90 (2007).
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 84-90
    • Zhao, W.1
  • 67
    • 34249287955 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Differentiation potential and therapeutic applications
    • Jackson L, et al, Adult mesenchymal stem cells: differentiation potential and therapeutic applications. J Postgrad Med 53:121-127 (2007).
    • (2007) J Postgrad Med , vol.53 , pp. 121-127
    • Jackson, L.1
  • 68
    • 12944258683 scopus 로고    scopus 로고
    • Immunophenotypic analysis of human articular chondrocytes: Changes in surface markers associated with cell expansion in monolayer culture
    • Diaz-Romero J, et al, Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture. J Cell Physiol 202:731-742 (2005).
    • (2005) J Cell Physiol , vol.202 , pp. 731-742
    • Diaz-Romero, J.1
  • 69
    • 11244281579 scopus 로고    scopus 로고
    • Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    • Li Y, et al, Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105:635 -637 (2005).
    • (2005) Blood , vol.105 , pp. 635-637
    • Li, Y.1
  • 70
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K and Yamanaka S, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 71
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita K, Ichisaka T and Yamanaka S, Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317 (2007).
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 72
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, et al, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 73
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Latest info. required
    • Yu J, et al, Induced pluripotent stem cell lines derived from human somatic cells. Science (2007). Latest info. required.
    • (2007) Science
    • Yu, J.1
  • 74
    • 37349028523 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
    • Latest info required
    • Nakagawa M, et al, Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007). Latest info required.
    • (2007) Nat Biotechnol
    • Nakagawa, M.1
  • 75
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for non-hematopoietic tissues
    • Prockop DJ, Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 276:71-74 (1997).
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 76
    • 0038664242 scopus 로고    scopus 로고
    • Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    • Gronthos S, et al, Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci 116:1827-1835 (2003).
    • (2003) J Cell Sci , vol.116 , pp. 1827-1835
    • Gronthos, S.1
  • 78
    • 0025741349 scopus 로고
    • Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1
    • Simmons PJ and Torok-Storb B, Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 78:55-62 (1991).
    • (1991) Blood , vol.78 , pp. 55-62
    • Simmons, P.J.1    Torok-Storb, B.2
  • 80
    • 0347363610 scopus 로고    scopus 로고
    • Membrane properties of rat embryonic multipotent neural stem cells
    • Cai J, et al, Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem 88:212-226 (2004).
    • (2004) J Neurochem , vol.88 , pp. 212-226
    • Cai, J.1
  • 81
    • 34248332602 scopus 로고    scopus 로고
    • Adipose-derived stem cells for regenerative medicine
    • Gimble JM, Katz AJ and Bunnell BA, Adipose-derived stem cells for regenerative medicine. Circ Res 100:1249-1260 (2007).
    • (2007) Circ Res , vol.100 , pp. 1249-1260
    • Gimble, J.M.1    Katz, A.J.2    Bunnell, B.A.3
  • 82
    • 0037221583 scopus 로고    scopus 로고
    • Characterization and functionality of cell surface molecules on human mesenchymal stem cells
    • Majumdar MK, et al, Characterization and functionality of cell surface molecules on human mesenchymal stem cells. J Biomed Sci 10:228-241 (2003).
    • (2003) J Biomed Sci , vol.10 , pp. 228-241
    • Majumdar, M.K.1
  • 83
    • 33646909199 scopus 로고    scopus 로고
    • High-yield isolation, expansion, and differentiation of rat bone marrow-derived mesenchymal stem cells with fibrin microbeads
    • Zangi L, et al, High-yield isolation, expansion, and differentiation of rat bone marrow-derived mesenchymal stem cells with fibrin microbeads. Tissue Eng 12:2343-2354 (2006).
    • (2006) Tissue Eng , vol.12 , pp. 2343-2354
    • Zangi, L.1
  • 84
    • 4544359550 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Isolation and therapeutics
    • Alhadlaq A and Mao JJ, Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 13:436-448 (2004).
    • (2004) Stem Cells Dev , vol.13 , pp. 436-448
    • Alhadlaq, A.1    Mao, J.J.2
  • 85
    • 0036248743 scopus 로고    scopus 로고
    • Isolation and characterization of size-sieved stem cells from human bone marrow
    • Hung SC, et al, Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells 20:249-258 (2002).
    • (2002) Stem Cells , vol.20 , pp. 249-258
    • Hung, S.C.1
  • 86
    • 0036901021 scopus 로고    scopus 로고
    • Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
    • Jones EA, et al, Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46:3349-3360 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 3349-3360
    • Jones, E.A.1
  • 87
    • 33947218520 scopus 로고    scopus 로고
    • Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation
    • Battula VL, et al, Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75:279-291 (2007).
    • (2007) Differentiation , vol.75 , pp. 279-291
    • Battula, V.L.1
  • 88
    • 4444300615 scopus 로고    scopus 로고
    • Human placenta-derived cells have mesenchymal stem/progenitor cell potential
    • Fukuchi Y, et al, Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells 22:649-658 (2004).
    • (2004) Stem Cells , vol.22 , pp. 649-658
    • Fukuchi, Y.1
  • 89
    • 33748307606 scopus 로고    scopus 로고
    • Isolation of mesenchymal stem cells from human placenta: Comparison with human bone marrow mesenchymal stem cells
    • Miao Z, et al, Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int 30:681-687 (2006).
    • (2006) Cell Biol Int , vol.30 , pp. 681-687
    • Miao, Z.1
  • 90
    • 3543022679 scopus 로고    scopus 로고
    • Plasticity of bone marrow-derived stem cells
    • Grove JE, Bruscia E and Krause DS, Plasticity of bone marrow-derived stem cells. Stem Cells 22:487-500 (2004).
    • (2004) Stem Cells , vol.22 , pp. 487-500
    • Grove, J.E.1    Bruscia, E.2    Krause, D.S.3
  • 91
    • 0031868140 scopus 로고    scopus 로고
    • The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects
    • Bruder SP, et al, The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 80:985-996 (1998).
    • (1998) J Bone Joint Surg Am , vol.80 , pp. 985-996
    • Bruder, S.P.1
  • 92
    • 0030907440 scopus 로고    scopus 로고
    • Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro
    • Kadiyala S, et al, Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant 6:125-134 (1997).
    • (1997) Cell Transplant , vol.6 , pp. 125-134
    • Kadiyala, S.1
  • 93
    • 2942568124 scopus 로고    scopus 로고
    • Bone marrow stromal cells (BMSCs) in bone engineering: Limitations and recent advances
    • Derubeis AR and Cancedda R, Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng 32:160-165 (2004).
    • (2004) Ann Biomed Eng , vol.32 , pp. 160-165
    • Derubeis, A.R.1    Cancedda, R.2
  • 94
    • 0032758946 scopus 로고    scopus 로고
    • Tissue engineering of bone. Cell based strategies
    • Bruder SP and Fox BS, Tissue engineering of bone. Cell based strategies. Clin Orthop 367:(Suppl): S68-S83 (1999).
    • (1999) Clin Orthop , vol.367 , Issue.SUPPL.
    • Bruder, S.P.1    Fox, B.S.2
  • 95
    • 4544273208 scopus 로고    scopus 로고
    • Bone tissue engineering: State of the art and future trends
    • Salgado AJ, Coutinho OP and Reis RL, Bone tissue engineering: state of the art and future trends. Macromol Biosci 4:743-765 (2004).
    • (2004) Macromol Biosci , vol.4 , pp. 743-765
    • Salgado, A.J.1    Coutinho, O.P.2    Reis, R.L.3
  • 96
    • 2942643980 scopus 로고    scopus 로고
    • Biological and biophysical principles in extracorporal bone tissue engineering. Part II
    • Meyer U, Joos U and Wiesmann HP, Biological and biophysical principles in extracorporal bone tissue engineering. Part II. Int J Oral Maxillofac Surg 33:325-332 (2004).
    • (2004) Int J Oral Maxillofac Surg , vol.33 , pp. 325-332
    • Meyer, U.1    Joos, U.2    Wiesmann, H.P.3
  • 97
    • 4344683871 scopus 로고    scopus 로고
    • Biological and biophysical principles in extracorporal bone tissue engineering. Part II
    • Meyer U, Joos U and Wiesmann HP, Biological and biophysical principles in extracorporal bone tissue engineering. Part II. Intl Oral Maxillofac Surg 33:523-530 (2004).
    • (2004) Intl Oral Maxillofac Surg , vol.33 , pp. 523-530
    • Meyer, U.1    Joos, U.2    Wiesmann, H.P.3
  • 98
    • 4444283223 scopus 로고    scopus 로고
    • Biological and biophysical principles in extracorporal bone tissue engineering. Part III
    • Meyer U, Joos U and Wiesmann HP, Biological and biophysical principles in extracorporal bone tissue engineering. Part III. Int J Oral Maxillofac Surg 33:635-641 (2004).
    • (2004) Int J Oral Maxillofac Surg , vol.33 , pp. 635-641
    • Meyer, U.1    Joos, U.2    Wiesmann, H.P.3
  • 99
    • 4344683871 scopus 로고    scopus 로고
    • Biological and biophysical principles in extracorporal bone tissue engineering. Part II
    • Wiesmann HP, Joos U and Meyer U, Biological and biophysical principles in extracorporal bone tissue engineering. Part II. Int J Oral Maxillofac Surg 33:523-530 (2004).
    • (2004) Int J Oral Maxillofac Surg , vol.33 , pp. 523-530
    • Wiesmann, H.P.1    Joos, U.2    Meyer, U.3
  • 100
    • 0033898092 scopus 로고    scopus 로고
    • In vitro engineering of cartilage
    • Glowacki J, In vitro engineering of cartilage. J Rehabil Res Dev 37:171-177 (2000).
    • (2000) J Rehabil Res Dev , vol.37 , pp. 171-177
    • Glowacki, J.1
  • 101
    • 0034792028 scopus 로고    scopus 로고
    • Symptomatic articular cartilage degeneration: The impact in the new millennium
    • Jackson DW, Simon TM and Aberman HM, Symptomatic articular cartilage degeneration: the impact in the new millennium. Clin Orthop 391:(Suppl): S14-S25 (2001).
    • (2001) Clin Orthop , vol.391 , Issue.SUPPL.
    • Jackson, D.W.1    Simon, T.M.2    Aberman, H.M.3
  • 102
    • 33645450704 scopus 로고    scopus 로고
    • Cartilage tissue engineering: Its potential and uses
    • Kuo CK, et al, Cartilage tissue engineering: its potential and uses. Curr Opin Rheumatol 18:64-73 (2006).
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 64-73
    • Kuo, C.K.1
  • 103
    • 0037258317 scopus 로고    scopus 로고
    • The use of specific chondrocyte populations to modulate the properties of tissue-engineered cartilage
    • Waldman SD, et al, The use of specific chondrocyte populations to modulate the properties of tissue-engineered cartilage. J Orthop Res 21:132-138 (2003).
    • (2003) J Orthop Res , vol.21 , pp. 132-138
    • Waldman, S.D.1
  • 104
    • 0036680533 scopus 로고    scopus 로고
    • Tissue engineering: Advances in in vitro cartilage generation
    • Risbud MV and Sittinger M, Tissue engineering: advances in in vitro cartilage generation. Trends Biotechnol 20:351-356 (2002).
    • (2002) Trends Biotechnol , vol.20 , pp. 351-356
    • Risbud, M.V.1    Sittinger, M.2
  • 105
    • 0034796201 scopus 로고    scopus 로고
    • Matrices for cartilage repair
    • Coutts RD, et al, Matrices for cartilage repair. Clin Orthop 391:(Suppl): S271-S279 (2001).
    • (2001) Clin Orthop , vol.391 , Issue.SUPPL.
    • Coutts, R.D.1
  • 106
    • 0036184589 scopus 로고    scopus 로고
    • Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees
    • Wakitani S, et al, Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 10:199-206 (2002).
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 199-206
    • Wakitani, S.1
  • 107
    • 41549122651 scopus 로고    scopus 로고
    • Osteochondral tissue engineering
    • Latest info. required
    • Martin I, et al, Osteochondral tissue engineering. J. Biomech (2006). Latest info. required.
    • (2006) J. Biomech
    • Martin, I.1
  • 108
    • 4444220390 scopus 로고    scopus 로고
    • Breast tissue engineering
    • Patrick CW, Breast tissue engineering. Annu Rev Biomed Eng 6:109-130 (2004).
    • (2004) Annu Rev Biomed Eng , vol.6 , pp. 109-130
    • Patrick, C.W.1
  • 109
    • 0034522196 scopus 로고    scopus 로고
    • Adipose tissue engineering: The future of breast and soft tissue reconstruction following tumor resection
    • Patrick CW Jr, Adipose tissue engineering: the future of breast and soft tissue reconstruction following tumor resection. Semin Surg Oncol 19:302-311 (2000).
    • (2000) Semin Surg Oncol , vol.19 , pp. 302-311
    • Patrick Jr, C.W.1
  • 110
  • 111
    • 33748777399 scopus 로고    scopus 로고
    • Stem cells and adipose tissue engineering
    • Gomillion CT and Burg KJ, Stem cells and adipose tissue engineering. Biomaterials 27:6052-6063 (2006).
    • (2006) Biomaterials , vol.27 , pp. 6052-6063
    • Gomillion, C.T.1    Burg, K.J.2
  • 112
    • 0035425429 scopus 로고    scopus 로고
    • Tissue engineering strategies for adipose tissue repair
    • Patrick CW Jr, Tissue engineering strategies for adipose tissue repair. Anat Rec 263:361-366 (2001).
    • (2001) Anat Rec , vol.263 , pp. 361-366
    • Patrick Jr, C.W.1
  • 113
    • 33750290856 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region
    • Miura M, et al, Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region. Oral Dis 12:514-522 (2006).
    • (2006) Oral Dis , vol.12 , pp. 514-522
    • Miura, M.1
  • 114
    • 18244377131 scopus 로고    scopus 로고
    • Ex vivo adipose tissue engineering by human marrow stromal cell seeded gelatin sponge
    • Hong L, et al, Ex vivo adipose tissue engineering by human marrow stromal cell seeded gelatin sponge. Ann Biomed Eng 33:511-517 (2005).
    • (2005) Ann Biomed Eng , vol.33 , pp. 511-517
    • Hong, L.1
  • 115
    • 18244381791 scopus 로고    scopus 로고
    • Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: Implications in soft tissue augmentation and reconstruction
    • Alhadlaq A, Tang M and Mao JJ, Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: implications in soft tissue augmentation and reconstruction. Tissue Eng 11:556-566 (2005).
    • (2005) Tissue Eng , vol.11 , pp. 556-566
    • Alhadlaq, A.1    Tang, M.2    Mao, J.J.3
  • 116
    • 20444402992 scopus 로고    scopus 로고
    • Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres
    • Choi YS, Park SN and Suh H, Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres. Biomaterials 26:5855-5863 (2005).
    • (2005) Biomaterials , vol.26 , pp. 5855-5863
    • Choi, Y.S.1    Park, S.N.2    Suh, H.3
  • 117
    • 18744373595 scopus 로고    scopus 로고
    • Human adipose tissue is a source of multipotent stem cells
    • Zuk PA, et al, Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279-4295 (2002).
    • (2002) Mol Biol Cell , vol.13 , pp. 4279-4295
    • Zuk, P.A.1
  • 118
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern S, et al, Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294-1301 (2006).
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1
  • 119
    • 34250882075 scopus 로고    scopus 로고
    • Prepare cells to repair the heart: Mesenchymal stem cells for the treatment of heart failure
    • Ohnishi S and Nagaya N, Prepare cells to repair the heart: mesenchymal stem cells for the treatment of heart failure. Am J Nephrol 27:301-307 (2007).
    • (2007) Am J Nephrol , vol.27 , pp. 301-307
    • Ohnishi, S.1    Nagaya, N.2
  • 120
    • 0344672626 scopus 로고    scopus 로고
    • Autologous transplantation of bone marrow cells improves damaged heart function
    • Tomita S, et al, Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100:11247-11256 (1999).
    • (1999) Circulation , vol.100 , pp. 11247-11256
    • Tomita, S.1
  • 121
    • 0035810240 scopus 로고    scopus 로고
    • Bone marrow cells regenerate infarcted myocardium
    • Orlic D, et al, Bone marrow cells regenerate infarcted myocardium. Nature 410:701-705 (2001).
    • (2001) Nature , vol.410 , pp. 701-705
    • Orlic, D.1
  • 122
    • 30344436968 scopus 로고    scopus 로고
    • Mesenchymal stem cells and the treatment of cardiac disease
    • Minguell JJ and Erices A, Mesenchymal stem cells and the treatment of cardiac disease. Exp Biol Med (Maywood) 231:39-49 (2006).
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 39-49
    • Minguell, J.J.1    Erices, A.2
  • 123
    • 18744403333 scopus 로고    scopus 로고
    • Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty")
    • Dengler TJ and Katus HA, Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty"). Herz 27:598-610 (2002).
    • (2002) Herz , vol.27 , pp. 598-610
    • Dengler, T.J.1    Katus, H.A.2
  • 124
    • 3142663241 scopus 로고    scopus 로고
    • Mesenchymal stem cells and their potential as cardiac therapeutics
    • Pittenger MF and Martin BJ, Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95:9-20 (2004).
    • (2004) Circ Res , vol.95 , pp. 9-20
    • Pittenger, M.F.1    Martin, B.J.2
  • 125
    • 27944464129 scopus 로고    scopus 로고
    • Emerging role for bone marrow derived mesenchymal stem cells in myocardial regenerative therapy
    • Zimmet JM and Hare JM, Emerging role for bone marrow derived mesenchymal stem cells in myocardial regenerative therapy. Basic Res Cardiol 100:471-481 (2005).
    • (2005) Basic Res Cardiol , vol.100 , pp. 471-481
    • Zimmet, J.M.1    Hare, J.M.2
  • 126
    • 19344377947 scopus 로고    scopus 로고
    • Bone marrow stem cell transplantation for cardiac repair
    • Haider H and Ashraf M, Bone marrow stem cell transplantation for cardiac repair. Am J. Physiol Heart Circ Physiol 288:H2557-H2567 (2005).
    • (2005) Am J. Physiol Heart Circ Physiol , vol.288
    • Haider, H.1    Ashraf, M.2
  • 127
  • 128
    • 33847256045 scopus 로고    scopus 로고
    • Progress and opportunities for tissue-engineered skin
    • MacNeil S ' Progress and opportunities for tissue-engineered skin. Nature 445:874-880 (2007).
    • (2007) Nature , vol.445 , pp. 874-880
    • MacNeil, S.1
  • 129
    • 27744572106 scopus 로고    scopus 로고
    • Tissue engineering of cultured sldn substitutes
    • Horch RE, et al, Tissue engineering of cultured sldn substitutes. J Cell Mol Med 9:592-608 (2005).
    • (2005) J Cell Mol Med , vol.9 , pp. 592-608
    • Horch, R.E.1
  • 130
    • 34249823651 scopus 로고    scopus 로고
    • Tissue engineering of replacement skin: The crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
    • Metcalfe AD and Ferguson MW, Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface 4:413-437 (2007).
    • (2007) J R Soc Interface , vol.4 , pp. 413-437
    • Metcalfe, A.D.1    Ferguson, M.W.2
  • 131
    • 34250883216 scopus 로고    scopus 로고
    • Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    • Falanga V, et al, Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 13:1299-1312 (2007).
    • (2007) Tissue Eng , vol.13 , pp. 1299-1312
    • Falanga, V.1
  • 132
    • 35348831024 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis, Latest info required
    • Wu Y, et al, Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells (2007). Latest info required).
    • (2007) Stem Cells
    • Wu, Y.1


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