Metabonomics in research of natural drugs and traditional Chinese medicines

Chinese Journal of Natural Medicines

Volumn 6, Issue 2, 2008, Pages 82-88

  Liu, Chang Xiao ^a   Si, Duan Yun ^a   Wan, Ren Zhong ^a   Lin, Yan Ping ^a   Xu, Yan Yan ^a  

^a TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Disease model research; Drug action mechanism; Drug safety; Metabonomics; Natural drugs; Traditional Chinese medicine

Indexed keywords

NATURAL PRODUCT;

ARTICLE; CHINESE MEDICINE; DRUG MECHANISM; DRUG RESEARCH; DRUG RESPONSE; DRUG SAFETY; METABOLOMICS; NONHUMAN;

EID: 41449092621     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.3724/SP.J.1009.2008.00082     Document Type: Article

References (36)

1. Lindon JC, Nicholson JK, Holmes E, et al. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project [J]. Toxicol Appl Pharmacol, 2003,187(3):137-146.
2. Oliver SG. Yeast as a navigational aid in genome analysis[J]. Metabology,1997,143(5): 1483-1484.
3. Espina JR, Shockcor JP,vHerron WJ. Detection of in vivo biomarkers of phospholipiodosis using NMR-based metabonomic approachers[J]. Magn Reson Chem,2001,39:559-565.
4. Shockcor JP, Holmes E. Metabonomic applications in toxicity screening and disease diagnosis[J]. Curr Top Med Chem,2002, 2(1): 35-51.
5. Liu CX. Chin Tradit Herb Drugs, 2004,35(6): 601-605.
6. Liu CX, Li C, Lin DH, et al. Significance of metabonomics in drug discovery and development[J]. Asian J Drug Metab Pharmacokinet, 2004, 4(2): 87-96.
7. Chinese source.
8. Chinese source.
9. Chinese source.
10. Chinese source.
11. Chinese source.
12. Chinese source.
13. Chinese source.
14. Chinese source.
15. Chinese source.
16. Wu XJ, Lin YP, Song LN, et al. Application of principal component analysis for data process in metabonomics studies[J]. Asian J Drug Metab Pharmacokinet, 2005,5 (4):287-294.
17. Wu XJ, Liu CX. Acta Pharm Sin, 2006,41(1):47-53.
18. Xu M, Lin DH, Liu CX. Acta Pharm Sin,2005,40(9):769-774.
19. Wu XJ, Yuan YJ, Liu CX J Chem Ind Eng),2005,56(1):1819-1825.
20. Huang YR, Wei GL, Xiao SH Chin Tradit Herb Drugs, 2005,36 (3): 301-305.
21. Watkins SM, Reifsnyder PR, Pan HJ. Lipid metabolome-wide effects of the PPAR gamma agonist rosiglitazone[J]. Lipid Res, 2002,43(11):1809-1817.
22. Slim RM, Robertson DG, Albassam M, et al. Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats[J]. Toxicol Appl Pharmacol, 2002,183(2):108-109.
23. Aardema MJ, MacGregor JT. Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies[J]. Mutat Res,2002, 499(1):13-25.
24. Qiu J. A culture in the balance:traditional Chinese medicine and western science face almost irreconcilable differences can systems biology bring them together? [J]. Nature,2007, 448: 126-128.
25. Qiu J. Back to the future for Chinese herbal medicines[J]. Nat Rev Drug Discov, 2007,6(7):506-507.
26. Lindon JC, Nicholson JK, Holmes E, et al. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project [J]. Toxicol Appl Pharmacol, 2003,187(3):137-146.
27. Nicholson JK, Lindon JC, Holmes E. "Metabonomics": understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data [J]. Xenobiotica, 1999, 29 (11): 1181-1189.
28. Nicholson JK, Connelly J, Lindon JC, et al. Metabonomics: a platform for studying drug toxicity and gene function[J]. Nat Rev Drug Discov,2002,1(2):153-161.
29. Robertaon DG, Reily MD, Sigler RE, et al. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants[J]. Toxicol Sci,2000,57(2):326-337.
30. Holmes E, Nicholls AW, Lindon JC, et al. Chemometric models for toxicity classification based on NMR spectra of biofluids[J]. Chem Res Toxicol,2000,13(6):471-478.
31. 1H NMR spectroscopic studies on intact rat renal cortex and medulla [J]. Magn Reson Med, 1999,41(6): 1108-1118.
32. 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue[J]. Magn Reson Med,2001,45(5): 781-790.
33. Kleno TG, Kiehr B, Baunsgaard D, et al. Combination of "omics" data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers [J]. Biomarkers, 2004,9(2):116-138.
34. Coen M, Ruepp SU, Lindon JC, et al. Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse[J]. J Pharm Biomed Anal, 2004, 35: 93-105.
35. Griffin JL, Bonney SA, Mann C, et al. An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver[J]. Physiol Genomics, 2004,17 (2):140-149.
36. Liu CX Acta Acad Med Sin,2007,29(6):712-718.