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Volumn 64, Issue 16, 2004, Pages 5720-5727

Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; CRM 197; DIPHTHERIA TOXIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; ILOMASTAT; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; RNA; UNCLASSIFIED DRUG;

EID: 4143151913     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0811     Document Type: Article
Times cited : (167)

References (50)
  • 2
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 3
    • 1642421130 scopus 로고    scopus 로고
    • Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment
    • Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS. Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 2003;10:1-21.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 1-21
    • Normanno, N.1    Bianco, C.2    De Luca, A.3    Maiello, M.R.4    Salomon, D.S.5
  • 4
    • 0026517954 scopus 로고
    • Significance of epidermal growth factor receptor in advanced ovarian cancer
    • Scambia G, Benedetti Panici P, Battaglia F, et al. Significance of epidermal growth factor receptor in advanced ovarian cancer. J Clin Oncol 1992;10:529-35.
    • (1992) J Clin Oncol , vol.10 , pp. 529-535
    • Scambia, G.1    Benedetti Panici, P.2    Battaglia, F.3
  • 5
    • 0036834993 scopus 로고    scopus 로고
    • Transforming growth factor alpha, amphiregulin and cripto-I are frequently expressed in advanced human ovarian carcinomas
    • D'Antonio A, Losito S, Pignata S, et al. Transforming growth factor alpha, amphiregulin and cripto-I are frequently expressed in advanced human ovarian carcinomas. Int J Oncol 2002;21:941-8.
    • (2002) Int J Oncol , vol.21 , pp. 941-948
    • D'Antonio, A.1    Losito, S.2    Pignata, S.3
  • 6
    • 0026005833 scopus 로고
    • Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitro
    • Morishige K, Kurachi H, Amemiya K, et al. Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitro. Cancer Res 1991;51:5322-8.
    • (1991) Cancer Res , vol.51 , pp. 5322-5328
    • Morishige, K.1    Kurachi, H.2    Amemiya, K.3
  • 7
    • 0026001496 scopus 로고
    • Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines
    • Morimoto H, Safrit JT, Bonavida B. Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines. J Immunol 1991;147:2609-16.
    • (1991) J Immunol , vol.147 , pp. 2609-2616
    • Morimoto, H.1    Safrit, J.T.2    Bonavida, B.3
  • 8
    • 0028284810 scopus 로고
    • Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity
    • Iwamoto R, Higashiyama S, Mitamura T, et al. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity. EMBO J 1994;13:2322-30.
    • (1994) EMBO J , vol.13 , pp. 2322-2330
    • Iwamoto, R.1    Higashiyama, S.2    Mitamura, T.3
  • 9
  • 10
    • 0029118420 scopus 로고
    • Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
    • Goishi K, Higashiyama S, Klagsbrun M, et al. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 1995;6:967-80.
    • (1995) Mol Biol Cell , vol.6 , pp. 967-980
    • Goishi, K.1    Higashiyama, S.2    Klagsbrun, M.3
  • 11
  • 12
    • 10744230888 scopus 로고    scopus 로고
    • Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities
    • Yamazaki S, Iwamoto R, Saeki K, et al. Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol 2003;163:469-75.
    • (2003) J Cell Biol , vol.163 , pp. 469-475
    • Yamazaki, S.1    Iwamoto, R.2    Saeki, K.3
  • 13
    • 0037593847 scopus 로고    scopus 로고
    • The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetra-decanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades
    • Takenobu H, Yamazaki A, Hirata M, Umata T, Mekada E. The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetra-decanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades. J Biol Chem 2003;278:17255-62.
    • (2003) J Biol Chem , vol.278 , pp. 17255-17262
    • Takenobu, H.1    Yamazaki, A.2    Hirata, M.3    Umata, T.4    Mekada, E.5
  • 14
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of pro-HB-EGF
    • Prenzel N, Zwick E, Daub H, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of pro-HB-EGF. Nature (Lond) 1999;402:884-8.
    • (1999) Nature (Lond) , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 15
    • 0034811076 scopus 로고    scopus 로고
    • Identification of serum factor inducing ectodomain shedding of pro-HB-EGF and studies of noncleavable mutants of pro-HB-EGF
    • Hirata M, Umata T, Takahashi T, et al. Identification of serum factor inducing ectodomain shedding of pro-HB-EGF and studies of noncleavable mutants of pro-HB-EGF. Biochem Biophys Res Commun 2001;283:915-22.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 915-922
    • Hirata, M.1    Umata, T.2    Takahashi, T.3
  • 16
    • 0023860289 scopus 로고
    • A putative new growth factor in ascitic fluid from ovarian cancer patients: Identification, characterization, and mechanism of action
    • Mills GB, May C, McGill M, Roifman CM, Mellors A. A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action. Cancer Res 1988;48:1066-71.
    • (1988) Cancer Res , vol.48 , pp. 1066-1071
    • Mills, G.B.1    May, C.2    McGill, M.3    Roifman, C.M.4    Mellors, A.5
  • 17
    • 0031747415 scopus 로고    scopus 로고
    • Malignant effusions contain lysophosphatidic acid (LPA)-like activity
    • Westermann AM, Havik E, Postma FR, et al. Malignant effusions contain lysophosphatidic acid (LPA)-like activity. Ann Oncol 1998;9:437-42.
    • (1998) Ann Oncol , vol.9 , pp. 437-442
    • Westermann, A.M.1    Havik, E.2    Postma, F.R.3
  • 18
    • 0028871499 scopus 로고
    • Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients
    • Xu Y, Gaudette DC, Boynton JD, et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res 1995;1:1223-32.
    • (1995) Clin Cancer Res , vol.1 , pp. 1223-1232
    • Xu, Y.1    Gaudette, D.C.2    Boynton, J.D.3
  • 20
    • 0242339246 scopus 로고    scopus 로고
    • Lysophosphatidic acid is a bioactive mediator in ovarian cancer
    • Fang X, Schummer M, Mao M, et al. Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim Biophys Acta 2002;1582:257-64.
    • (2002) Biochim Biophys Acta , vol.1582 , pp. 257-264
    • Fang, X.1    Schummer, M.2    Mao, M.3
  • 21
    • 0034062462 scopus 로고    scopus 로고
    • Mechanisms of lysolipid phosphate effects on cellular survival and proliferation
    • Goetzl EJ, Lee H, Dolezalova H, et al. Mechanisms of lysolipid phosphate effects on cellular survival and proliferation. Ann N Y Acad Sci 2000;905:177-87.
    • (2000) Ann N Y Acad Sci , vol.905 , pp. 177-187
    • Goetzl, E.J.1    Lee, H.2    Dolezalova, H.3
  • 22
    • 0032569235 scopus 로고    scopus 로고
    • Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers
    • Xu Y, Shen Z, Wiper DW, et al. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 1998;280:719-23.
    • (1998) JAMA , vol.280 , pp. 719-723
    • Xu, Y.1    Shen, Z.2    Wiper, D.W.3
  • 23
    • 0038581051 scopus 로고    scopus 로고
    • TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells
    • Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 2003;22:2411-21.
    • (2003) EMBO J , vol.22 , pp. 2411-2421
    • Gschwind, A.1    Hart, S.2    Fischer, O.M.3    Ullrich, A.4
  • 24
    • 0015919833 scopus 로고
    • Diphtheria toxin and related proteins. I. Isolation and properties of mutant proteins serologically related to diphtheria toxin
    • Uchida T, Pappenheimer AM Jr, Greany R. Diphtheria toxin and related proteins. I. Isolation and properties of mutant proteins serologically related to diphtheria toxin. J Biol Chem 1973;248:3838-44.
    • (1973) J Biol Chem , vol.248 , pp. 3838-3844
    • Uchida, T.1    Pappenheimer Jr., A.M.2    Greany, R.3
  • 26
    • 0037021437 scopus 로고    scopus 로고
    • Small interfering RNA and gene silencing in transgenic mice and rats
    • Hasuwa H, Kaseda K, Einarsdottir T, Okabe M. Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Lett 2002;532:227-30.
    • (2002) FEBS Lett , vol.532 , pp. 227-230
    • Hasuwa, H.1    Kaseda, K.2    Einarsdottir, T.3    Okabe, M.4
  • 27
    • 0028954797 scopus 로고
    • Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
    • Miyamoto S, Akiyama SK, Yamada KM. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (Wash DC) 1995;267:883-5.
    • (1995) Science (Wash DC) , vol.267 , pp. 883-885
    • Miyamoto, S.1    Akiyama, S.K.2    Yamada, K.M.3
  • 28
    • 0033520312 scopus 로고    scopus 로고
    • Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor
    • Iwamoto R, Handa K, Mekada E. Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor. J Biol Chem 1999;274:25906-12.
    • (1999) J Biol Chem , vol.274 , pp. 25906-25912
    • Iwamoto, R.1    Handa, K.2    Mekada, E.3
  • 29
    • 0026425674 scopus 로고
    • Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a Taxol analogue
    • Bissery MC, Guenard D, Gueritte-Voegelein F, Lavelle F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a Taxol analogue. Cancer Res 1991;51:4845-52.
    • (1991) Cancer Res , vol.51 , pp. 4845-4852
    • Bissery, M.C.1    Guenard, D.2    Gueritte-Voegelein, F.3    Lavelle, F.4
  • 30
    • 0037474724 scopus 로고    scopus 로고
    • Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer
    • Fujita T, Miyamoto S, Onoyama I, et al. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. Cancer Lett 2003;192:161-9.
    • (2003) Cancer Lett , vol.192 , pp. 161-169
    • Fujita, T.1    Miyamoto, S.2    Onoyama, I.3
  • 31
    • 0033304670 scopus 로고    scopus 로고
    • Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate
    • Adam RM, Borer JG, Williams J, Eastham JA, Loughlin KR, Freeman MR. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology 1999;140:5866-75.
    • (1999) Endocrinology , vol.140 , pp. 5866-5875
    • Adam, R.M.1    Borer, J.G.2    Williams, J.3    Eastham, J.A.4    Loughlin, K.R.5    Freeman, M.R.6
  • 32
    • 0034007763 scopus 로고    scopus 로고
    • Cell surface activities of the human type 2b phosphatidic acid phosphatase
    • Ishikawa T, Kai M, Wada I, Kanoh H. Cell surface activities of the human type 2b phosphatidic acid phosphatase. J Biochem (Tokyo) 2000;127:645-51.
    • (2000) J Biochem (Tokyo) , vol.127 , pp. 645-651
    • Ishikawa, T.1    Kai, M.2    Wada, I.3    Kanoh, H.4
  • 33
    • 0037374562 scopus 로고    scopus 로고
    • The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: Validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer
    • Tanyi JL, Morris AJ, Wolf JK, et al. The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Cancer Res 2003;63:1073-82.
    • (2003) Cancer Res , vol.63 , pp. 1073-1082
    • Tanyi, J.L.1    Morris, A.J.2    Wolf, J.K.3
  • 34
    • 0028860250 scopus 로고
    • Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
    • Mitamura T, Higashiyama S, Taniguchi N, Klagsbrun M, Mekada E. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 1995;270:1015-9.
    • (1995) J Biol Chem , vol.270 , pp. 1015-1019
    • Mitamura, T.1    Higashiyama, S.2    Taniguchi, N.3    Klagsbrun, M.4    Mekada, E.5
  • 35
    • 1642351380 scopus 로고    scopus 로고
    • In vivo establishment and characterization of a paclitaxel-resistant human ovarian cancer cell line showing enhanced growth properties and drug-resistance only in vivo
    • Okugawa K, Kobayashi H, Hirakawa T, et al. In vivo establishment and characterization of a paclitaxel-resistant human ovarian cancer cell line showing enhanced growth properties and drug-resistance only in vivo. J Cancer Res Clin Oncol 2004;130:178-86.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 178-186
    • Okugawa, K.1    Kobayashi, H.2    Hirakawa, T.3
  • 36
    • 0035839427 scopus 로고    scopus 로고
    • A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor
    • Umata T, Hirata M, Takahashi T, et al. A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. J Biol Chem 2001;276:30475-82.
    • (2001) J Biol Chem , vol.276 , pp. 30475-30482
    • Umata, T.1    Hirata, M.2    Takahashi, T.3
  • 37
    • 0034083409 scopus 로고    scopus 로고
    • Constitutive and lysophosphatidic acid (LPA)-induced LPA production: Role of phospholipase D and phospholipase A2
    • Eder AM, Sasagawa T, Mao M, Aoki J, Mills GB. Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. Clin Cancer Res 2000;6:2482-91.
    • (2000) Clin Cancer Res , vol.6 , pp. 2482-2491
    • Eder, A.M.1    Sasagawa, T.2    Mao, M.3    Aoki, J.4    Mills, G.B.5
  • 38
    • 0026748744 scopus 로고
    • Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid
    • van der Bend RL, Brunner J, Jalink K, et al. Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. EMBO J 1992;11:2495-501.
    • (1992) EMBO J , vol.11 , pp. 2495-2501
    • Van Der Bend, R.L.1    Brunner, J.2    Jalink, K.3
  • 39
    • 0032496366 scopus 로고    scopus 로고
    • Identification of a novel human phosphatidic acid phosphatase type 2 isoform
    • Hooks SB, Ragan SP, Lynch KR. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. FEBS Lett 1998;427:188-92.
    • (1998) FEBS Lett , vol.427 , pp. 188-192
    • Hooks, S.B.1    Ragan, S.P.2    Lynch, K.R.3
  • 40
    • 0025341727 scopus 로고
    • TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
    • Jhappan C, Stahle C, Harkins RN, et al. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 1990;61:1137-46.
    • (1990) Cell , vol.61 , pp. 1137-1146
    • Jhappan, C.1    Stahle, C.2    Harkins, R.N.3
  • 41
    • 0025297086 scopus 로고
    • Overexpression of TGF alpha in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
    • Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990;61:1121-35.
    • (1990) Cell , vol.61 , pp. 1121-1135
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 42
    • 0033547421 scopus 로고    scopus 로고
    • Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line
    • Ma L, Gauville C, Berthois Y, et al. Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line. Oncogene 1999;18:6513-20.
    • (1999) Oncogene , vol.18 , pp. 6513-6520
    • Ma, L.1    Gauville, C.2    Berthois, Y.3
  • 43
    • 0034785693 scopus 로고    scopus 로고
    • Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases
    • Shen Z, Wu M, Elson P, et al. Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases. Gynecol Oncol 2001;83:25-30.
    • (2001) Gynecol Oncol , vol.83 , pp. 25-30
    • Shen, Z.1    Wu, M.2    Elson, P.3
  • 45
    • 0032442191 scopus 로고    scopus 로고
    • Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells
    • Shen Z, Belinson J, Morton RE, Xu Y. Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells. Gynecol Oncol 1998;71:364-8.
    • (1998) Gynecol Oncol , vol.71 , pp. 364-368
    • Shen, Z.1    Belinson, J.2    Morton, R.E.3    Xu, Y.4
  • 46
    • 0036140653 scopus 로고    scopus 로고
    • Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors
    • Tokumura A, Tominaga K, Yasuda K, et al. Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors. Cancer (Phila) 2002;94:141-51.
    • (2002) Cancer (Phila) , vol.94 , pp. 141-151
    • Tokumura, A.1    Tominaga, K.2    Yasuda, K.3
  • 47
    • 0028931859 scopus 로고
    • Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells
    • Yeo EJ, Exton JH. Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. J Biol Chem 1995;270:3980-8.
    • (1995) J Biol Chem , vol.270 , pp. 3980-3988
    • Yeo, E.J.1    Exton, J.H.2
  • 48
    • 0030836586 scopus 로고    scopus 로고
    • Properties and regulation of cytosolic phospholipase A2
    • Leslie CC. Properties and regulation of cytosolic phospholipase A2. J Biol Chem 1997;272:16709-12.
    • (1997) J Biol Chem , vol.272 , pp. 16709-16712
    • Leslie, C.C.1
  • 49
    • 0028037574 scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes
    • Hashimoto K, Higashiyama S, Asada H, et al. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 1994;269:20060-6.
    • (1994) J Biol Chem , vol.269 , pp. 20060-20066
    • Hashimoto, K.1    Higashiyama, S.2    Asada, H.3
  • 50
    • 0037453001 scopus 로고    scopus 로고
    • Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
    • Iwamoto R, Yamazaki S, Asakura M, et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci USA 2003;100:3221-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3221-3226
    • Iwamoto, R.1    Yamazaki, S.2    Asakura, M.3


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