Inhibition of Na +-H + exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction

British Journal of Pharmacology

Volumn 142, Issue 7, 2004, Pages 1147-1154

  Rungwerth, Katrin ^a   Schindler, Ursula ^a   Gerl, Martin ^a   Schäfer, Stefan ^a   Licher, Thomas ^a   Busch, Andreas E ^a   Ruetten, Hartmut ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

C reactive protein; Heart failure; Inflammation; Myocardial infarction; Na + H + exchanger; PV loops; Rabbit; Remodeling

Indexed keywords

ALDOSTERONE; C REACTIVE PROTEIN; CARIPORIDE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTOLE; ECHOCARDIOGRAPHY; HEART FAILURE; HEART HEMODYNAMICS; HEART INFARCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE RELAXATION; HEART LEFT VENTRICLE VOLUME; HEART PRELOAD; HEART STROKE VOLUME; HEART WORK; MALE; MORPHOMETRICS; MYOCARDITIS; NONHUMAN; PIEZOELECTRICITY; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTON SODIUM EXCHANGE; RABBIT; SHAM FEEDING;

ALDOSTERONE; ANIMALS; C-REACTIVE PROTEIN; ELECTROCARDIOGRAPHY; GUANIDINES; HEART FAILURE, CONGESTIVE; INFLAMMATION; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RABBITS; SODIUM-HYDROGEN ANTIPORTER; SULFONES; SURVIVAL RATE; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 4143137496     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705746     Document Type: Article

References (35)

1. ALONSO MARTINEZ, J.L., LLORENTE DIEZ, B., ECHEGARAY AGARA, M., URBIETA-ECHEZARRETA, M. & GONZALEZ-ARECIBIA, C. (2002). C-reactive protein as a predictor of improvement and readmission in heart failure. Eur. J. Heart Fail., 4, 331-336.
2. BOLGER, A.P., SHARMA, R., LI, W., LEENARTS, M., KAIRA, P.R., KEMP, M., COATS, A.J., ANKER, S.D. & GATZOULIS, M.A. (2002). Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation, 106, 2-9.
3. BOLOGNESE, L. & CERISANO, G. (1999). Early predictors of left ventricular remodeling after acute myocardial infarction. Am. Heart J., 138, S79-S83.
4. CAMILION DE HURTADO, M.C., PORTIANSKY, E.L., PEREZ, N.G., REBOLLEDO, O.R. & CINGOLANI, H.E. (2002). Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+)-exchanger. Cardiovasc. Res., 53, 862-868.
5. CHEN, L., CHEN, C.X., GAN, X.T., BEIER, N., SCHOLZ, W. & KARMAZYN, M. (2004). Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition. Am. J. Physiol. Heart Circ. Physiol., 286, H381-H387.
6. + exchange inhibitor cariporide. J. Pharmacol. Exp. Ther., 298, 469-476.
7. DHIR, M. & NAGUEH, S.F. (2002). Echocardiography and prognosis of heart failure. Curr. Opin. Cardiol., 17, 253-256.
8. +-exchanger and cardiac hypertrophy. Circ. Res., 83, 870-873.
9. ENGELHARDT, S., HEIN, L., KELLER, U., KLAMBT, K. & LOHSE, M.J. (2002). Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circ. Res., 90, 81-89.
10. HATTORI, R., OTANI, H., MORIGUCHI, Y., MATSUBARA, H., YAMAMURA, T., NAKAO, Y., OMIYA, H., OSAKO, M. & IMAMURA, H. (2001). NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells. Am. J. Physiol. Heart Circ. Physiol., 280, H2796-H2803.
11. HAYASAKI, Y., KAJIWARA, Y., KITANO, Y., IWASAKI, T., SHIMAMURA, T., NAYA, N., IWAKI, K. & NAKAJIMA, M. (1999). Na(+)influx via Na(+)/H(+) exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes. J. Mol. Cell. Cardiol., 31, 1559-1572.
12. +-exchange in norepinephrine induced protein synthesis in neonatal cultured cardiomyocytes. Jpn. Circ. J., 54, 535-539.
13. KARMAZYN, M., GAN, X.T., HUMPHREYS, R.A., YOSHIDA, H. & KUSUMOTO, H. (1999). The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease. Circ. Res., 85, 777-786.
14. +/H+-exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Drugs, 61, 375-389.
15. KELL, R., HAUNSTETTER, A., DENGLER, T.J., ZUGCK, C., KUBLER, W. & HAASS, M. (2002). Do cytokines enable risk stratification to be improved in NYHA functional class III patients? Comparison with other potential predictors of prognosis. Eur. Heart J., 23, 70-78.
16. KINUGAWA, T., OSAKI, S., KATO, M., OGINO, K., SHIMOYAMA, M., TOMIKURA, Y., IGAWA, O., HISATOME, I. & SHIGEMASA, C. (2002). Effects of the angiotensin converting enzyme inhibitor alacepril on exercise capacity and neurohormonal factors in patients with mild-to-moderate heart failure. Clin. Exp. Pharmacol. Physiol., 29, 1060-1065.
17. KNIGHT, D.R., SMITH, A.H., FLYNN, D.M., MACANDREW, J.T., ELLERY, S.S., KONG, J.X., MARALA, R.B., WESTER, R.T., GUZAM-PEREZ, A., HILL, R.J., MAGEE, W.P. & TRACEY, W.M. (2001). A novel sodium hydrogen exchanger isoform 1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J. Pharmacol. Exp. Ther., 297, 254-259.
18. KRAMER, B.K., SMITH, T.W. & KELLY, R.A. (1991). Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C dependent Na(+)-H+ exchanger. Circ. Res., 68, 269-279.
19. KUBOTA, T., MIYAGISHIMA, M., ALVAREZ, R.J., KORMOS, R., ROSENBLUM, W.R., DEMETRIS, A.J., SEMIGRAN, A.J., DEC, G.W., HOLUBKOV, R., MCTIERNAN, C.F., MANN, D.L. & FELDMAN, A.R. (2000). Expression of proinflammatory cytokines in the failing human heart: comparison of recent onset and end stage congestive heart failure. J. Heart Lung Transplant., 19, 819-824.
20. + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Am. J. Physiol. Heart Circ., 280, H738-H745.
21. LINZ, W., ALBUS, U., CRAUSE, P., JUNG, W., WEICHERT, A., SCHOLKENS, B.A. & SCHOLZ, W. (1998). Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clin. Exp. Hypertens., 20, 733-749.
22. LOENNECHEN, J.P., WISLOFF, U., FALCK, G. & ELLINGSEN, O. (2002). Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure. Circulation, 105, 1380-1386.
23. MANN, D.L. (2002). Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ. Res., 91, 988-998.
24. MATSUI, H., BARRY, W.H., LIVSEY, C.L. & SPITZER, K.W. (1995). Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc. Res., 29, 215-221.
25. MCKAY, R.G., PFEFFER, M.A., PASTERNAK, R.C.L., MARKIS, J.E., COME, P.C., NAKAO, S., ALDERMAN, J.D., FERGUSON, J.J., SAFIAN, R.D. & GROSSMAN, W. (1986). Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation, 74, 693-702.
26. MCSWINE, R.L., BABNIGG, G., MUSCH, M.W., CHANG, E.B. & VILLEREAL, M.L. (1994). Expression and phosphorylation of NHE1 in wild type and transformed human and rodent fibroblasts. J. Cell. Physiol., 161, 351-357.
27. REDLIN, M., WERNER, J., HABAZETTL, H., GRIETHE, W., KUPPE, H. & PRIES, A.S. (2001). Cariporide (HOE 642) attenuates leukocyte activation in ischemia and reperfusion. Anesth. Analg., 93, 1472-1479.
28. RUPPRECHT, H.J., VOM-DAHL, J., TERRES, W., SEYFARTH, K.M., RICHARDT, G., SCHULTHEIBETA, H.P., BUERKE, M., SHEEHAN, F.H. & DREXLER, H. (2000). Cardioprotective effects of the Na(+)/H(+) exchange inhibitor canporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation, 101, 2902-2908.
29. + exchanger subtype 3 in various cell types. Pflugers Arch., 436, 797-800.
30. TENDERA, M. & OCHALA, A. (2001). Overview of the results of recent beta blocker trials. Curr. Opin. Cardiol. 16, 180-185.
31. + exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate. Arzneimittelforschung, 47, 1204-1207.
32. YAMAZAKI, T., KOMURO, I., KUDOH, S., ZOU, Y., NAGAI, R., AIKAWA, R., UOZOMI, H. & YAZAKI, Y. (1998). Role of ion channels and exchangers in mechanical stretch induced cardiomyocyte hypertrophy. Circ. Res., 82, 430-437.
33. YASUTAKE, M., HAWORTH, R.S., KING, L. & AVKIRAN, M. (1996). Thrombin activates the sarcolemmal Na(+)-H+ exchanger. Evidence for a receptor mediated mechanism involving protein kinase C. Circ. Res., 79, 705-715.
34. + exchanger activity and expression in human ventricular myocardium. J. Am. Coll. Cardiol., 36, 534-540.
35. + exchanger activity in rat ventricular myocytes: evidence for selective mediation by the alpha1A-adrenoceptor subtype. Circ. Res., 82, 1078-1085.