Drug development for ovarian hyper-stimulation and anti-cancer treatment: Blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis

Biochemical Pharmacology

Volumn 68, Issue 6, 2004, Pages 989-996

  Freimann, S ^a   Ben Ami, I ^b   Hirsh, L ^a   Dantes, A ^a   Halperin, R ^b   Amsterdam, A ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b ASSAF HAROFEH MEDICAL CENTER   (Israel)

Author keywords

EGF like growth factors; Gonadotropins; Ovarian cancer; Ovulation

Indexed keywords

AMPHIREGULIN; ANTINEOPLASTIC AGENT; EPIREGULIN; GONADOTROPIN; LUTEINIZING HORMONE;

ATTENUATION; BIOSYNTHESIS; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOMETRIUM; GENETIC CODE; HUMAN; HUMAN CELL; MITOGENESIS; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; OVARY HYPERSTIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TARGET CELL;

ANTINEOPLASTIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; DRUG DESIGN; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION; GLYCOPROTEINS; GONADOTROPINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUTEINIZING HORMONE; OVARIAN NEOPLASMS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 4143104855     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.05.027     Document Type: Conference Paper

References (66)

1. Amsterdam A., Rotmensch S. Structure-function relationships during granulosa cell differentiation. Endocrinol. Rev. 8:1987;309-338
2. Amsterdam A., Rotmensch S., Ben-Ze'ev A. Coordinated regulation of morphological and biochemical differentiation in a steroidogenic cell. Trends Biochem. Sci. 14:1989;377-382
3. Amsterdam A., Koch Y., Lieberman M.E., Lindner H.R. Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat. J. Cell Biol. 67:1975;894-900
4. Peng X.R., Hsueh A.J., LaPolt P.S., Bjersing L., Ny T. Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation. Endocrinology. 129(6):1991;3200-3207
5. Amsterdam A., Josephs R., Lieberman M.E., Lindner H.R. Organization of intramembrane particles in freeze-cleaved gap junctions of rat graafian rollicles: optical-diffraction analysis. J. Cell Sci. 21(1):1976;93-105
6. Al-Timimi A., Buckley C.H., Fox H. An immunohistochemical study of the incidence and significance of human gonadotrophin and prolactin binding sites in normal and neoplastic human ovarian tissue. Br. J. Cancer. 53:1986;321-329
7. Amsterdam A, Rotmensch S, Ben-Ze'ev A. Structure-function relationships in the differentiating granulosa cell. In: Motta PM, editor. Progress in chemical and biological research, vol. 296. Developments in ultrastructure of reproduction. New York: Alan Liss; 1989. p. 121-30.
8. Amsterdam A., Plehn-Dujowich D., Suh B.S. Structure-function relationships during differentiation of normal and oncogene transformed granulosa cells. Biol. Reprod. 46:1992;513-522
9. Rao C.V. Multiple novel roles of luteinizing hormone. Fertil. Steril. 76:2001;1097-1100
10. Mandai M., Konishi I., Kuroda H., Fukumoto M., Komatsu T., Yamamoto S., et al. Messenger ribonucleic acid expression of LH/hCG receptor gene in human ovarian carcinomas. Eur J. Cancer. 33:1997;1501-1507
11. Nakano R., Kitayama S., Yamoto M., Shima K., Ooshima A. Localization of gonadotropin binding sites in human ovarian neoplasms. Am. J. Obstet. Gynecol. 161:1989;905-910
12. Mahlck C.G., Grankvist K., Kjellgren O., Backstrom T. Human chorionic gonadotropin, follicle-stimulating hormone, and luteinizing hormone in patients with epithelial ovarian carcinoma. Gynecol. Oncol. 36:1990;219-225
13. Kramer S., Leeker M., Jager W. Gonadotropin levels in ovarian cyst fluids: a predictor of malignancy? Int. J. Biol. Markers. 13:1998;165-168
14. Halperin R., Hadas E., Langer R., Bukovsky I., Schneider D. Peritoneal fluid gonadotropins and ovarian hormones in patients with ovarian cancer. Int. J. Gynecol. Cancer. 9:1999;502-507
15. Halperin R., Pansky M., Vaknin Z., Zehavi S., Bukovsky I., Schneider D. Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma. Eur. J. Obstet. Gynecol. Reprod. Biol. 110:2003;207-210
16. Park JY, Su YQ, Ariga M, Law E, Jin SL, Conti M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 2004;303(5658):682-4.
17. Carter M.E., Joyce D.N. Ovarian carcinoma in a patient hyperstimulated by gonadotropin therapy for in vitro fertilization: a case report. J. In Vitro Fertil. Embryo Transfer. 4:1987;126-128
18. Wimalasena J., Meehan D., Cavallo C. Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins. Gynecol. Oncol. 41:1991;56-63
19. Hoermann R., Gerbes A.L., Spoettl G., Jungst D., Mann K. Immunoreactive human chorionic gonadotropin and its free beta subunit in serum and ascites of patients with malignant tumors. Cancer Res. 52:1992;1520-1524
20. Rossing M.A., Daling J.R., Weiss N.S., Moore D.E., Self S.G. Ovarian tumors in a cohort of infertile women. N. Engl. J. Med. 331:1994;771-776
21. Helzlsouer K.J., Alberg A.J., Gordon G.B., Longcope C., Bush T.L., Hoffman S.C., et al. Serum gonadotropins and steroid hormones and the development of ovarian cancer. J. Am. Med. Assoc. 274:1995;1926-1930
22. Jager W., Dittrich R., Recabarren S., Wildt L., Lang N. Induction of ovarian tumors by endogenous gonadotropins in rats bearing intrasplenic ovarian grafts. Tumor Biol. 16:1995;268-280
23. Shushan A., Paltiel O., Iscovich J., Elchalal U., Peretz T., Schenker J.G. Human menopausal gonadotropin and the risk of epithelial ovarian cancer. Fertil. Steril. 65:1996;13-18
24. Sasson R., Amsterdam A. Stimulation of apoptosis in human granulosa cells from in vitro fertilization patients and its prevention by dexamethasone: involvement of cell contact and bcl-2 expression. J. Clin. Endocrinol. Metab. 87:2002;3441-3451
25. Sasson R., Dantes A., Tajima K., Amsterdam A. Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action. FASEB J. 17:2003;1256-1266
26. Sasson R., Shinder V., Dantes A., Land A., Amsterdam A. Activation of multiple signal transduction pathways by glucocorticoids: protection of ovarian follicular cells against apoptosis. Biochem. Biophys. Res. Commun. 311:2003;1047-1056
27. Breckwoldt M., Selvaraj N., Aharoni D., Barash A., Segal I., Insler V., et al. Expression of Ad4-BP/cytochrome P450 side chain cleavage enzyme and induction of cell death in long-term cultures of human granulosa cells. Mol. Hum. Reprod. 2:1996;391-400
28. Amsterdam A, Sasson R. Generation and application of ovarian steroidogenic cell lines. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 353-402.
29. Huirne J.A., Lambalk C.B., van Loenen A.C., Schats R., Hompes P.G., Fauser B.C., et al. Contemporary pharmacological manipulation in assisted reproduction. Drugs. 64(3):2004;297-322
30. Fauser B.C., Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol. Metab. 14(5):2003;236-242
31. Sasson R., Rimon E., Dantes A., Amsterdam A. Gonadotropins induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic cytoskeletal and genes coding for apoptotic signaling and kinases. Mol. Hum. Reprod. 10(5):2004;299-311
32. Amsterdam A. Novel genes regulated by gonadotropins in granulosa cells: new perspectives on their physiological functions. Mol. Cell Endocrinol. 202:2003;133-137
33. Liu J., Kuulasmaa T., Kosma V.M., Butzow R., Vanttinen T., Hyden-Granskog C., et al. Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. J. Clin. Endocrinol. Metab. 88(10):2003;5002-5008
34. Xu J., Luo X., Chegini N. Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog. J. Clin. Endocrinol. Metab. 88(3):2003;1350-1361
35. Komurasaki T., Toyoda H., Uchida D., Morimoto S. Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. Oncogene. 15:1997;2841-2848
36. Sun W.S., Fujimoto J., Tamaya T. Clinical implications of coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine leiomyoma. Mol. Hum. Reprod. 9(11):2003;701-707
37. Sekiguchi T., Mizutani T., Yamada K., Yazawa T., Kawata H., Yoshino M., et al. Transcriptional regulation of the epiregulin gene in the rat ovary. Endocrinology. 143:2002;4718-4729
38. Toyoda H., Komurasaki T., Uchida D., Takayama Y., Isobe T., Okuyama T., et al. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J. Biol. Chem. 270:1995;7495-7500
39. Toyoda H., Komurasaki T., Uchida D., Morimoto S. Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. Biochem. J. 326:1997;69-75
40. Sasaki E., Arakawa T., Fujiwara Y., Kawada N., Fukuda T., Higuchi K., et al. Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal growth factor receptor. Eur. J. Pharmacol. 338:1997;253-258
41. Baba I., Shirasawa S., Iwamoto R., Okumura K., Tsunoda T., Nishioka M., et al. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Cancer Res. 60:2000;6886-6889
42. Zhu Z., Kleeff J., Friess H., Wang L., Zimmermann A., Yarden Y., et al. Epiregulin is up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth. Biochem. Biophys. Res. Commun. 273:2000;1019-1024
43. Komurasaki T., Toyoda H., Uchida D., Morimoto S. Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. Oncogene. 15:1997;2841-2848
44. Ma L., de Roquancourt A., Bertheau P., Chevret S., Millot G., Sastre-Garau X., et al. Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions. J. Pathol. 194:2001;413-419
45. D'Antonio A., Losito S., Pignata S., Grassi M., Perrone F., De Luca A., et al. Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int. J. Oncol. 21:2002;941-948
46. Seals D.F., Courtneidge S.A. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 17:2003;7-30
47. Offenhauser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., et al. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol. Biol. Cell. 15(1):2004;91-98
48. Leu T.H., Yeh H.H., Huang C.C., Chuang Y.C., Su S.L., Maa M.C. Participation of p97Eps8 in Src-mediated transformation. J. Biol. Chem. 279(11):2004;9875-9881
49. Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 22:2001;255-288
50. Ausberg N, Woo MMM. Development and differenciation of ovarian surface epithelium:cause for the basis of its malignant potential. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 579-86.
51. Ziecik A.J., Derecka K., Gawronska B., Stepien A., Bodek G. Nongonadal LH/hCG receptors in pig: functional importance and parallels to human. Semin. Reprod. Med. 19:2001;19-30
52. Rulli S.B., Kuorelahti A., Karaer O., Pelliniemi L.J., Poutanen M., Huhtaniemi I. Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology. 143:2002;4084-4095
53. Blaakaer J., Bennett P., Micic S., Toftager-Larsen K., Hording U., Bock J.E., et al. The post-operative gonadotropin level in post-menopausal women with epithelial ovarian cancer. Eur. J. Obstet. Gynecol. Reprod. Biol. 52:1993;111-116
54. Jager W., Wildt L., Lang N. Some observations on the effect of a GnRH analog in ovarian cancer. Eur. J. Obstet. Gynecol. Reprod. Biol. 32:1989;137-148
55. Vanderhyden BC, Shaw TJ, Carson K, Tonary AM. Ovarian carcinogenesis. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 591-602.
56. Surmacz E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene. 22(42):2003;6589-6597
57. Espey L.L., Richards J.S. Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. Biol. Reprod. 6:2002;1662-1670
58. Leonard D.S., Hill A.D., Kelly L., Dijkstra B., McDermott E., O'Higgins N.J. Anti-human epidermal growth factor receptor 2 monoclonal antibody therapy for breast cancer. Br. J. Surg. 89(3):2002;262-271
59. Asada S., Choi Y., Yamada M., Wang S.C., Hung M.C., Qin J., et al. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc. Natl. Acad. Sci. U.S.A. 99(20):2002;12747-12752
60. Rajagopal S., Huang S., Moskal T.L., Lee B.N., el-Naggar A.K., Chakrabarty S. Epidermal growth factor expression in human colon and colon carcinomas: anti-sense epidermal growth factor receptor RNA down-regulates the proliferation of human colon cancer cells. Int. J. Cancer. 62(6):1995;661-667
61. Gschwind A., Hart S., Fischer O.M., Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J. 22(10):2003;2411-2421
62. Sales KJ, Maudsley S, Jabbour HN. Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes VEGF expression via cAMP-mediated transactivation of the EGF receptor and ERK1/2 signaling pathways. Mol Endocrinol 2004;18:1533-45.
63. Amsterdam A., Hasoch T., Dantes A., Tajima J., Strauss J.F. III, Seger R. Mechanisms of gonadotropin desensitization. Mol. Cell. Endocrinol. 187:2001;69-74
64. Tajima K., Dantes A., Yao Z., Sorokina K., Kotsuji F., Seger R., et al. Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. J. Clin. Endocrinol. Metab. 88:2003;2288-2299
65. Seger R., Hanoch T., Rosenberg R., Dantes A., Merz W.E., Strauss J.F. III, et al. The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J. Biol. Chem. 276:2001;13957-13964
66. Amsterdam A., Hasoch T., Dantes A., Tajima K., Strauss J.F. III, Seger R. Mechanisms of gonadotropin desensitization. Mol. Cell. Endocrinol. 187:2001;69-74