Expression of Betaglycan, an Inhibin Coreceptor, in Normal Human Ovaries and Ovarian Sex Cord-Stromal Tumors and Its Regulation in Cultured Human Granulosa-Luteal Cells

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 10, 2003, Pages 5002-5008

  Liu, Jianqi ^a   Kuulasmaa, Tiina ^b   Kosma, Veli Matti ^b,c   Bützow, Ralf ^a,d   Vänttinen, Teemu ^b   Hydén Granskog, Christel ^d   Voutilainen, Raimo ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR 2; BETA GLYCAN; BUCLADESINE; BUTAPROST; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOLLITROPIN; GLYCAN DERIVATIVE; GONADOTROPIN; INHIBIN; LUTEINIZING HORMONE; PHORBOL 13 ACETATE 12 MYRISTATE; PROGESTERONE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROTEIN KINASE C ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE III RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BETA GLYCAN GENE; CELL CULTURE; CONTROLLED STUDY; CORPUS LUTEUM; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; FEMALE; FERTILIZATION IN VITRO; FIBROMA; FIBROTHECOMA; GENE; GENE EXPRESSION; GRANULOSA CELL; GRANULOSA CELL TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUTEAL CELL; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OVARY; OVARY FUNCTION; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX CORD STROMAL TUMOR; SEX CORD TUMOR; SIGNAL TRANSDUCTION; STAINING; STEROIDOGENESIS; STROMA CELL; THECA CELL; THECOMA;

ACTIVINS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; FEMALE; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBINS; LUTEAL CELLS; LUTEINIZING HORMONE; OVARIAN NEOPLASMS; OXYTOCICS; PROTEIN KINASE C; PROTEOGLYCANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SEX CORD-GONADAL STROMAL TUMORS;

EID: 0242383312     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030704     Document Type: Article

References (39)

1. Halvorson LM, DeCherney AH 1996 Inhibin, activin, and follistatin in reproductive medicine. Fertil Steril 65:459-469
2. Pangas SA, Woodruff TK 2000 Activin signal transduction pathways. Trends Endocrinol Metab 11:309-314
3. Chapman SC, Bernard DJ, Jelen J, Woodruff TK 2002 Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors. Mol Cell Endocrinol 196:79-93
4. Findlay JK, Drummond AE, Dyson M, Baillie AJ, Robertson DM, Ethier JF 2001 Production and actions of inhibin and activin during folliculogenesis in the rat. Mol Cell Endocrinol 180:139-144
5. Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W 2000 Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404:411-414
6. Esparza-Lopez J, Montiel JL, Vilchis-Landeros MM, Okadome T, Miyazono K, Lopez-Casillas F 2001 Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-β superfamily. Specialized binding regions for transforming growth factor-β and inhibin α. J Biol Chem 276:14588-14596
7. Gray PC, Bilezikjian LM, Vale W 2002 Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan. Mol Cell Endocrinol 188:254-260
8. Wiater E, Vale W 2003 Inhibin is an antagonist of bone morphogenetic protein signaling. J Biol Chem 278:7934-7941
9. Knight PG, Glister C 2001 Potential local regulatory functions of inhibins, activins and follistatin in the ovary. Reproduction 121:503-512
10. Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW, Bradley A 1992 α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360:313-319
11. Erämaa M, Hildén K, Tuuri T, Ritvos O 1995 Regulation of inhibin/activin subunit messenger ribonucleic acids (mRNAs) by activin A and expression of activin receptor mRNAs in cultured human granulosa-luteal cells. Endocrinology 136:4382-4389
12. Sidis Y, Fujiwara T, Leykin L, Isaacson K, Toth T, Schneyer AL 1998 Characterization of inhibin/activin subunit, activin receptor, and follistatin messenger ribonucleic acid in human and mouse oocytes: evidence for activin's paracrine signaling from granulosa cells to oocytes. Biol Reprod 59:807-812
13. Ito I, Minegishi T, Fukuda J, Shinozaki H, Auersperg N, Leung PCK 2000 Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma. Br J Cancer 82:1415-1420
14. Goddard I, Hendrick JC, Benahmed M, Morera AM 1995 Transforming growth factor-β receptor expression in cultured porcine granulosa cells. Mol Cell Endocrinol 115:207-213
15. Drummond AE, Le MT, Ethier J-F, Dyson M, Findlay JK 2002 Expression and localization of activin receptors, Smads, and βglycan to the postnatal rat ovary. Endocrinology 143:1423-1433
16. Fuller PJ, Zumpe ET, Chu S, Mamers P, Burger HG 2002 Inhibin-activin receptor subunit gene expression in ovarian tumors. J Clin Endocrinol Metab 87:1395-1401
17. B subunit mRNA in cultured human granulosaluteal cells. Mol Hum Reprod 7:319-323
18. Liu J, Kosma V-M, Vänttinen T, Hydén-Granskog C, Voutilainen R 2002 Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells. Mol Hum Reprod 8:136-141
19. Laitinen MPE, Anttonen M, Ketola I, Wilson DB, Ritvos O, Butzow R, Heikinheimo M 2000 Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors. J Clin Endocrinol Metab 85:3476-3483
20. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP 1998 Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4:844-847
21. Voutilainen R, Tapanainen J, Chung B, Matteson KJ, Miller WL 1986 Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17α-hydroxylase/17,20-lyase) in cultured human granulosa cells. J Clin Endocrinol Metab 63:202-207
22. Schipper I, Fauser BCJM, van Gaver EBO, Zarutskie PW, Dahl KD 1993 Development of a human granulosa cell culture model with follicle stimulating hormone responsiveness. Hum Reprod 8:1380-1386
23. A-subunit mRNA and secretion of dimeric inhibin A in cultured human granulosa-luteal cells. Mol Hum Reprod 2:815-822
24. Liu J, Heikkilä P, Kahri AI, Voutilainen R 1996 Expression of the steroidogenic acute regulatory protein mRNA in adrenal tumors and cultured adrenal cells. J Endocrinol 150:43-50
25. Moren A, Ichijo H, Miyazono K 1992 Molecular cloning and characterization of the human and porcine transforming growth factor-β type III receptors. Biochem Biophys Res Commun 189:356-362
26. Arnheim N 1979 Characterization of mouse ribosomal gene fragments purified by molecular cloning. Gene 7:83-96
27. Voutilainen R, Franks S, Mason HD, Martikainen H 1996 Expression of insulin-like growth factor (IGF), IGF-binding protein, and IGF-receptor messenger ribonucleic acids in normal and polycystic ovaries. J Clin Endocrinol Metab 81:1003-1008
28. Duncan WC 2000 The human corpus luteum: remodelling during luteolysis and maternal recognition of pregnancy. Rev Reprod 5:12-17
29. 2 in cultured granulosa-luteal cells. Mol Hum Reprod 8:992-997
30. Zosmer A, Elder MG, Sullivan MHF 2002 The production of progesterone and 5,6-epoxyeicosatrienoic acid by human granulosa cells. J Steroid Biochem Mol Biol 81:369-376
31. Pangas SA, Rademaker AW, Fishman DA, Woodruff TK 2002 Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary. J Clin Endocrinol Metab 87:2644-2657
32. Choi YL, Kim HS, Ahn G 2000 Immunoexpression of inhibin α subunit, inhibin/activin βA subunit and CD99 in ovarian tumors. Arch Pathol Lab Med 124:563-569
33. Strauss III JF, Steinkampf MP 1995 Pituitary-ovarian interactions during follicular maturation and ovulation. Am J Obstet Gynecol 172:726-735
34. Vänttinen T, Liu J, Hydén-Granskog C, Voutilainen R 2002 Biphasic regulation of activin A secretion by gonadotropins in cultured human ovarian granulosa-luteal cells leads to decreasing activin:inhibin ratios during continuing gonadotropin stimulation. J Endocrinol 172:557-563
35. Harris TE, Squires PE, Michael AE, Bernal AL, Abayasekara DR 2001 Human granulosa-lutein cells express functional EP1 and EP2 prostaglandin receptors. Biochem Biophys Res Commun 285:1089-1094
36. 2 and different growth factors. Biol Reprod 53:1508-1516
37. Tsuchida K, Arai KY, Kuramoto Y, Yamakawa N, Hasegawa Y, Sugino H 2000 Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-β family. J Biol Chem 275:40788-40796
38. Sidis Y, Tortoriello DV, Holmes WE, Pan Y, Keutmann HT, Schneyer AL 2002 Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin. Endocrinology 143:1613-1624
39. Richards JS, Russell DL, Robker RL, Dajee M, Alliston TN 1998 Molecular mechanisms of ovulation and luteinization. Mol Cell Endocrinol 145:47-54