The role of dendritic cells in asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 4, Issue 1, 2004, Pages 39-44

  Holt, Patrick G ^a   Upham, John W ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Allergy; Antigen presenting cells; Asthma; Dendritic cells; Immune tolerance

Indexed keywords

ANTIGEN; B7 ANTIGEN; CD86 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLERGY; ANTIGEN PRESENTING CELL; ASTHMA; ATOPY; CELL ACTIVITY; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CELL POPULATION; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DENDRITIC CELL; EOSINOPHILIA; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LUNG ALVEOLUS CELL; LYMPH NODE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY SYSTEM; REVIEW; SENSITIZATION; TH1 CELL; TH2 CELL;

ASTHMA; DENDRITIC CELLS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; RESPIRATORY SYSTEM; T-LYMPHOCYTES;

EID: 4143085893     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200402000-00009     Document Type: Review

References (51)

1. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol 2000; 106:1033-1042.
2. Ying S, Durham SR, Corrigan CJ, et al. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995; 12:477-487.
3. Humbert M, Menz G, Ying S, et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20:528-533.
4. Holt PG, Schon-Hegrad MA, Oliver J, et al. A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium. Int Arch Allergy Appl Immunol 1990; 91:155-159.
5. Stumbles PA, Upham JW, Holt PG. Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract. APMIS 2003; 111:741-755.
6. Holt PG, Degebrodt A, O'Leary C, et al. T cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages. Clin Exp Immunol 1985; 62:586-593.
7. Stumbles PA, Thomas JA, Pimm CL, et al. Resting respiratory tract dendritic cells preferentially stimulate Th2 responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med 1998; 188:2019-2031.
8. Holt PG, Haining S, Nelson DJ, Sedgwick JD. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 1994; 153:256-261.
9. Nelson DJ, McMenamin C, McWilliam AS, et al. Development of the airway intraepithelial dendritic cell network in the rat from class II MHC (la) negative precursors: differential regulation of la expression at different levels of the respiratory tract. J Exp Med 1994; 179:203-212.
10. McWilliam AS, Nelson D, Thomas JA, Holt PG. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J Exp Med 1994; 179:1331-1336.
11. Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (la)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991; 173:1345-1356.
12. Legge KL, Braciale TJ. Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection. Immunity 2003; 18:265-277. Respiratory viral infection induces a rapid but transient migration of dendritic cells from the lungs to regional lymph nodes.
13. McWilliam AS, Marsh AM, Holt PG. Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells. J Virol 1997; 71:226-236.
14. Lambrecht BN, Carro-Muino I, Vermaelen K, Pauwels RA. Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats. Am J Respir Cell Mol Biol 1999; 20:1165-1174.
15. McWilliam AS, Napoli S, Marsh AM, et al. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J Exp Med 1996; 184:2429-2432.
16. Holt PG, Stumbles PA. Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: the respiratory tract as a paradigm. J Allergy Clin Immunol 2000; 105:421-429.
17. Stampfli MR, Wiley RE, Neigh GS, et al. GM-CSF transgene expression in the airways allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998; 102:1704-1714.
18. Yamamoto N, Suzuki S, Shirai, A, et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur J Immunol 2000; 30:316-326.
19. Lambrecht BN, De Veerman M, Coyle AJ, et al. Myloid dendritic cells induce Th2 responses to inhaled antigen leading to eosinophilic airway inflammation. J Clin Invest 2000; 106:551-559.
20. Lambrecht BN, Salomon B, Klatzmann D, Pauwels RA. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol 1998; 160:4090-4097.
21. Moller GM, Overbeek SE, Van Helden-Meeuwsen CG, et al. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy 1996; 26:517-524.
22. Tunon-de-lara JM, Redington AE, Bradding P, et al. Dendritic cells in normal and ashmatic airways: expression of the α subunit of the high affinity immunoglobulin E receptor (FcεRI-α). Clin Exp Allergy 1996; 26:648-655.
23. Jahnsen F, Moloney ED, Hogan T, et al. Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 2001; 56:823-826.
24. Hammad H, Charbonnier AS, Duez C, et al. Th2 polarization by Der p 1-pulsed monocyte-derived dendritic cells is due to the allergic status of the donors. Blood 2001; 98:1135-1141.
25. Reider N, Reider D, Ebner S, et al. Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production. J Allergy Clin Immunol 2002; 109:89-95.
26. Bellinghausen I, Brand U, Knop J, Salonga J. Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors. J Allergy Clin Immunol 2000; 105:988-996.
27. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14:353-356.
28. Miyazaki S, Tsuda H, Sakai M, et al. Predominance of Th2-promoting dendritic cells in early human pregnancy decidua. J Leukoc Biol 2003; 74:514-522. The majority of dendritic cells in the normal human placenta are myeloid, rather than plasmacytoid, and they preferentially induce Th2 differentiation by naïve T cells. This may contribute to the Th2 skewed environment of pregnancy.
29. Holt PG, Macaubas C. Development of long term tolerance versus sensitization to environmental allergens during the perinatal period. Curr Opin Immunol 1997; 9:782-787.
30. Hagendorens MM, Ebo DG, Schuerwegh AJ, et al. Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children. Clin Exp Allergy 2003; 33:633-639. Numbers of circulating plasmacytoid dendritic cells are lower in allergic asthmatic children compared with healthy children. Numbers of myeloid dendritic cells were similar in both groups, but were correlated with eosinophil counts in the allergic children.
31. Matsuda H, Suda T, Hashizume H, et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma. Am J Respir Crit Care Med 2002; 166:1050-1054. Numbers of circulating plasmacytoid dendritic cells are higher in adults with asthma than in healthy controls, in contrast to the findings of Hagendorens et al. [30]. Numbers of myeloid dendritic cells were similar in both asthmatic and control groups.
32. Novak N, Tepel C, Koch S, et al. Evidence for a differential expression of the FcεR1γ chain in dendritic cells of atopic and nonatopic donors. J Clin Invest 2003; 111:1047-1056. Important study comparing high-affinity IgE receptor expression on dendritic cells from atopic and nonatopic individuals. FcεR1α is expressed on dendritic cells from both groups, but differential expression of the γ chain on dendritic cells from atopics is associated with sustained expression of FcεR1.
33. Kalinski P, Hilkens CM, Snijders A, et al. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159:28-35.
34. Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol 2003; 170:4457-4464. Production of IL-6 by lung dendritic cells negatively regulates IL-12 synthesis and inhibits Th1 development. This may partly explain the propensity of lung dendritic cells to induce Th2 differentiation.
35. Schipf A, Heilmann A, Boue L, et al. Th2 cells shape the differentiation of developing T cell responses during interactions with dendritic cells in vivo. Eur J Immunol 2003; 33:1697-1706. Th2 cells within lymph nodes can skew bystander Th1 cells towards a Th2 phenotype.
36. Hammad H, Lambrecht BN, Pochard P, et al. Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7. J Immunol 2002; 169:1524-1534. Transfer of human dendritic cells from atopic donors into severe combined immune deficiency mice will selectively induce Th2 polarized immunity and allergic inflammation in the mice.
37. Holt PG, Sedgwick JD. Suppression of IgE responses following antigen inhalation: a natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today 1987; 8:14-15.
38. Akbari O, Freeman GJ, Meyer EH, et al. Antigen-specific regulatory T cells develop via ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002; 8:1024-1032. Important study showing that lung dendritic cells can induce regulatory T cells and that regional lymph node dendritic cells can transfer antigen-specific tolerance to recipient animals. Both the development and function of T regulatory cells are dependent on IL-10 and ICOS-ICOS ligand interactions.
39. Lagranderie M, Nahori M-A, Balazuc A-M, et al. Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production. Immunology 2003; 108:352-364. Intranasal delivery of BCG induces recruitment into the lungs of dendritic cells and macrophages that produce high levels of IL-12 and induce long-lived Th1 cells.
40. Kuipers H, Hijdra D, de Vries VC, et al. Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells. J Immunol 2003; 171:3645-3654. Lipopolysaccharide exposure reduces airway eosinophilia and Th2 cytokine production, but surprisingly, this is not dependent on IL-12.
41. Eisenbarth SC, Piggott DA, Huleatt JW, et al. Lipopolysaccharide- enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-1651. The ability of lipopolysaccharide to alter Th1/Th2 switching is dose dependent. Low-dose inhaled lipopolysaccharide favours Th2 responses, whereas high-dose inhaled lipopolysaccharide favours Th1 responses.
42. Cates EC, Gajewska BU, Goncharova S, et al. Effect of GM-CSF on immune, inflammatory, and clinical responses top ragweed in a novel mouse model of mucosal sensitization. J Allergy Clin Immunol 2003; 111:1076-1086. This study examines the role of GM-CSF in mucosal sensitization to a clinically relevant allergen, using an experimental system that is not dependent on intraperitoneal adjuvant.
43. Stewart GA, Holt PG. Immunogenicity and tolerogenicity of a major house dust mite allergen, Der p 1 from Dermatophagoides pteronyssinus, in mice and rats. Int Arch Allergy Appl Immunol 1987; 83:44-51.
44. Ghaemmaghami AM, Gough L, Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level. Clin Exp Allergy 2002; 32:1468-1475. The enzymatic properties of the mite allergen Der p 1 cleave CD40 from the surface of dendritic cells, reducing their ability to synthesize IL-12, and enhancing Th2 cytokine production. It will be interesting to see if these effects differ in dendritic cells from allergic compared with nonallergic individuals.
45. Charbonnier AS, Hammad H, Gosset P, et al. Der p 1-pulsed myeloid and plasmatoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response. J Leukoc Biol 2003; 73:91-99. Compares the effects of Der p 1 on circulating dendritic cell subsets.
46. Upham JW, Denburg JA, O'Byrne PM. Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects. Clin Exp Allergy 2002; 32:818-823.
47. Nelson DJ, McWilliam AS, Haining S, Holt PG. Modulation of airway intraepithelial dendritic cells following exposure to steroids. Am J Respir Crit Care Med 1995; 151:475-481.
48. van Rijt LS, Prins J-B, Leenen PJ, et al. Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31 (hl) Ly-6C (neg) bone marrow precursors in a mouse model of asthma. Blood 2002; 100:3663-3671. Inhaled allergen induces an increase in airway dendritic cells associated with expansion of myeloid dendritic cell precursors.
49. Hwang J, Yen D, Tschernig T, et al. Interleukin-13 and interferon modulations of dendritic cell migration in the lungs. Chest 2003; 123:439S-445S. Intranasal challenge of mice with IL-13 and IFNγ led to increased numbers of airway dendritic cells and increased migration of dendritic cells to regional lymph nodes.
50. Holt PG, Oliver J, Bilyk N, et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 1993; 177:397-407.
51. Huh JC, Strickland DH, Jahnsen FL, et al. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T-cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 2003; 198:19-30. First study to dissect out the differential effects of inhaled allergen on airway versus parenchymal lung dendritic cells. Cognate interactions between antigen loaded dendritic cells and memory T cells leads to rapid maturation of dendritic cell function within 2 h of allergen exposure.