DNA binding ligands with improved in vitro and in vivo potency against drug-resistant Staphylococcus aureus

Journal of Medicinal Chemistry

Volumn 47, Issue 18, 2004, Pages 4352-4355

  Hu, Wenhao ^a   Bürli, Roland W ^a   Kaizerman, Jacob A ^a   Johnson, Kirk W ^a   Gross, Matthew I ^a   Iwamoto, Mari ^a   Jones, Peter ^a   Lofland, Denene ^a   Difuntorum, Stacey ^a   Chen, Hsiu ^a   Bozdogan, Bülent ^b   Appelbaum, Peter C ^b   Moser, Heinz E ^a  

^a Genesoft Pharmaceuticals Inc   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYPIPERIDINE; ANTIINFECTIVE AGENT; BENZOTHIOPHENE; DISTAMYCIN A; LIGAND; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PERITONITIS; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG DOSE; DRUG POTENCY; DRUG RESISTANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; DISTAMYCINS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; KINETICS; LIGANDS; METHICILLIN; MICE; PERITONITIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SURVIVAL RATE; VANCOMYCIN;

EID: 4143052371     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049712g     Document Type: Article

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