DNA binding ligands with in vivo efficacy in murine models of bacterial infection: Optimization of internal aromatic amino acids

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2067-2072

  Bürli, Roland W ^a   Kaizerman, Jacob A ^a   Duan, Jian Xin ^a   Jones, Peter ^a   Johnson, Kirk W ^a   Iwamoto, Mari ^a   Truong, Kiet ^a   Hu, Wenhao ^a   Stanton, Timothy ^a   Chen, Alfred ^a   Touami, Sofia ^a   Gross, Matthew ^a   Jiang, Vernon ^a   Ge, Yigong ^a   Moser, Heinz E ^a  

^a Genesoft Pharmaceuticals Inc   (United States)

Author keywords

Antibiotics; DNA ligands; Lead optimization; MRSA

Indexed keywords

AROMATIC AMINO ACID; DNA; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PERITONITIS; BACTERICIDAL ACTIVITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISEASE MODEL; DNA BINDING; DRUG EFFICACY; DRUG PURIFICATION; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGAND BINDING; LUNG INFECTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS, AROMATIC; ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DNA; LIGANDS; LUNG DISEASES; MICE; PERITONITIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); MURINAE; POSIBACTERIA;

EID: 11144353762     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.047     Document Type: Article

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