메뉴 건너뛰기




Volumn 90, Issue 3, 1999, Pages 766-771

Clinical isoflurane metabolism by cytochrome P450 2E1

Author keywords

CYP2E1; Drug interactions; Enflurane; Halothane; Isoniazid; Sevoflurane; Toxicity

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2E1; DISULFIRAM; FENTANYL; FLUORIDE; ISOFLURANE; PROPOFOL; SUXAMETHONIUM; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

EID: 0032965115     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199903000-00019     Document Type: Article
Times cited : (58)

References (38)
  • 1
    • 0021166824 scopus 로고
    • Isoflurane: A comparison of its metabolism by human and rat hepatic cytochrome P-450
    • Bradshaw JJ, Ivanetich KM: Isoflurane: A comparison of its metabolism by human and rat hepatic cytochrome P-450. Anesth Analg 1984; 63:805-13
    • (1984) Anesth Analg , vol.63 , pp. 805-813
  • 2
    • 0023848847 scopus 로고
    • Potential metabolic basis for enflnrane hepatitis and tlie apparent cross-sensitization between enflurane and halothane
    • Christ DD, Satoh H, Kenna JG, Pohl LR: Potential metabolic basis for enflnrane hepatitis and tlie apparent cross-sensitization between enflurane and halothane. Drug Metab Dispos 1988; 16:135-40
    • (1988) Drug Metab Dispos , vol.16 , pp. 135-140
  • 3
    • 0023152896 scopus 로고
    • Hepatic dysfunction after isoflurane anesthesia
    • Stocking RK, Blitt CD, Cohen PJ, Merin RG: Hepatic dysfunction after isoflurane anesthesia. Anesth Analg 1987; 66:147-53
    • (1987) Anesth Analg , vol.66 , pp. 147-153
  • 4
    • 0026671668 scopus 로고
    • Postoperative elevation of serum transaminases following isoflurane anesthesia
    • Gunza JT, Pashayan AG: Postoperative elevation of serum transaminases following isoflurane anesthesia. J Clin Anesth 1992; 4:336-41
    • (1992) J Clin Anesth , vol.4 , pp. 336-341
  • 5
    • 0029803964 scopus 로고    scopus 로고
    • Isoflurane hepatotoxicity: A case report and review of the literature
    • Sinha A, Clatch RJ, Stuck G, Blumenthal SA, Patel SA: Isoflurane hepatotoxicity: A case report and review of the literature. Am J Gastroenterol 1996; 91:2406-9
    • (1996) Am J Gastroenterol , vol.91 , pp. 2406-2409
  • 6
    • 0024267822 scopus 로고
    • Evidence for expression in human liver of halothane-induced neoantigens by antibodies in sera from patients with halothane hepatitis
    • Kenna JG, Neuberger J, Williams R: Evidence for expression in human liver of halothane-induced neoantigens by antibodies in sera from patients with halothane hepatitis. Hepatology 1988; 8:1635-41
    • (1988) Hepatology , vol.8 , pp. 1635-1641
  • 7
    • 0028030973 scopus 로고
    • Ilyin GP, Rissel M, Malledant Y, Tanguy M, Guillouzo A: Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane. Biochem Pharmacol 1994; 48:561-7
    • (1994) Biochem Pharmacol , vol.48 , pp. 561-567
  • 8
  • 9
    • 0027220076 scopus 로고
    • Mechanisms of halothane toxicity: Novel insights
    • Gut J, Christen U, HuwylerJ: Mechanisms of halothane toxicity: Novel insights. Pharmacol Ther 1993; 58:133-55
    • (1993) Pharmacol Ther , vol.58 , pp. 133-155
  • 10
    • 0023769618 scopus 로고
    • Biotransformation of isoflurane: Urinary and serum fluoride ion and organic fluorine
    • Davidkova T, Kikuchi H, Fujii K, Mukaida K, Sato N, Kawachi S, Morio M: Biotransformation of isoflurane: Urinary and serum fluoride ion and organic fluorine. ANESTHESIOLOGY 1988; 69:218-22
    • (1988) ANESTHESIOLOGY , vol.69 , pp. 218-222
  • 11
    • 0030868233 scopus 로고    scopus 로고
    • The role of cytochrome P450 3A4 in alfcntanil clearance: Implications for interindividual variability in disposition and perioperative drug interactions
    • Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle TA, Cox K: The role of cytochrome P450 3A4 in alfcntanil clearance: Implications for interindividual variability in disposition and perioperative drug interactions. AXESTIIESIOLOGY 1997; 87:36-50
    • (1997) AXESTIIESIOLOGY , vol.87 , pp. 36-50
    • Kharasch, E.D.1    Russell, M.2    Mautz, D.3    Thummel, K.E.4    Kunze, K.L.5    Bowdle, T.A.6    Cox, K.7
  • 14
    • 0029984604 scopus 로고    scopus 로고
    • Identification of the enzyme responsible for oxidative halothane metabolism: Implications for prevention of halothane hepatitis
    • Kharasch ED, Hankins D, Mautz D, Thummel KE: Identification of the enzyme responsible for oxidative halothane metabolism: Implications for prevention of halothane hepatitis. Lancet 1996; 347:1367-71
    • (1996) Lancet , vol.347 , pp. 1367-1371
    • Kharasch, E.D.1    Hankins, D.2    Mautz, D.3    Thummel, K.E.4
  • 15
    • 0027417453 scopus 로고
    • Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1
    • Thummcl KE, Kharasch ED, Podoll T, Kunze K: Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1. Drug Metab Dispos 1993; 21:350-7
    • (1993) Drug Metab Dispos , vol.21 , pp. 350-357
    • Thummcl, K.E.1    Kharasch, E.D.2    Podoll, T.3    Kunze, K.4
  • 16
    • 0027515708 scopus 로고
    • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane
    • Kharasch ED, Thummel KE: Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane. A.NESTHESIOLOGY 1993; 79:795-807
    • (1993) A.NESTHESIOLOGY , vol.79 , pp. 795-807
    • Thummel Ke, K.E.D.1
  • 18
    • 0027159323 scopus 로고
    • Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1
    • Kharasch ED, Thummel K, Mhyre J, Lillibridge J: Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1. Clin Pharmacol Ther 1993; 53:643-50
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 643-650
    • Kharasch, E.D.1    Thummel, K.2    Mhyre, J.3    Lillibridge, J.4
  • 19
    • 0026035519 scopus 로고
    • Role of human P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich FP, Kirn D-H, Iwasaki M: Role of human P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem ResToxicol 1991; 4:168-79
    • (1991) Chem ResToxicol , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kirn, D.-H.2    Iwasaki, M.3
  • 21
    • 0030953275 scopus 로고    scopus 로고
    • Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography
    • Hankins DC, Kharasch ED: Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography. J Chromatogr B 1997; 692: 413-8
    • (1997) J Chromatogr B , vol.692 , pp. 413-418
    • Kharasch Ed, H.D.C.1
  • 23
    • 0016252246 scopus 로고
    • Renal effects and metabolism of isoflurane in man
    • Mazze RI, Cousins MJ, Darr GA: Renal effects and metabolism of isoflurane in man. A.NESTHESIOLOGY 1974; 40:536-42
    • (1974) A.NESTHESIOLOGY , vol.40 , pp. 536-542
    • Mazze, R.I.1    Cousins, M.J.2    Darr, G.A.3
  • 25
    • 0026744568 scopus 로고
    • Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialk} lamines and tobacco-related nitrosamines in human liver microsomes
    • Yamazaki H, Inui Y, Yun OH, Guengerich FP, Shimada T: Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialk} lamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis 1992; 13:1789-94
    • (1992) Carcinogenesis , vol.13 , pp. 1789-1794
    • Yamazaki, H.1    Inui, Y.2    Yun, O.H.3    Guengerich, F.P.4    Shimada, T.5
  • 26
    • 0027270458 scopus 로고
    • High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans
    • Camus A-M, Geneste O, Honkakoski P, Bereziat J-C, Henderson CJ, Wolf CR, Bartsch II, Lang MA: High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans. Mol Carcinogen 1993; 7:268-75
    • (1993) Mol Carcinogen , vol.7 , pp. 268-275
    • Camus, A.-M.1    Geneste, O.2    Honkakoski, P.3    Bereziat, J.-C.4    Henderson, C.J.5    Wolf, C.R.6    Bartsch, I.I.7    Lang, M.A.8
  • 27
    • 0028340688 scopus 로고
    • Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1
    • Duescher RJ, Elfarra AA: Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1. Arch Biochem Biophys 1994; 311:342-9
    • (1994) Arch Biochem Biophys , vol.311 , pp. 342-349
    • Elfarra Aa, D.R.J.1
  • 28
    • 0027219159 scopus 로고
    • Retroviral mediated expression of human cytochrome P4502A6 in C3H/10T1/2 cells confers transformabilit}- By 4 methylnitrosamino H3-pyridyl l-butanone (NNK)
    • Tiano HF, Hosokawa M, Chulada PC, Smith PB, Wang R-L, Gonzalez FJ, Crespi CL, Langenbach R: Retroviral mediated expression of human cytochrome P4502A6 in C3H/10T1/2 cells confers transformabilit}- by 4 methylnitrosamino H3-pyridyl l-butanone (NNK). Carcinogenesis 1993; 14:1421-7
    • (1993) Carcinogenesis , vol.14 , pp. 1421-1427
    • Tiano, H.F.1    Hosokawa, M.2    Chulada, P.C.3    Smith, P.B.4    Wang, R.-L.5    Gonzalez, F.J.6    Crespi, C.L.7    Langenbach, R.8
  • 29
    • 0028174881 scopus 로고
    • Evaluation of triacetyloleandomycin, a-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450
    • ChangTKH, Gonzalez FJ, Waxman DJ: Evaluation of triacetyloleandomycin, a-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch Biochem Biophys 1994; 311:437-42
    • (1994) Arch Biochem Biophys , vol.311 , pp. 437-442
    • Chang, T.K.H.1    Gonzalez, F.J.2    Waxman, D.J.3
  • 30
    • 0030056594 scopus 로고    scopus 로고
    • Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
    • Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsui M: Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica 1996; 26: 681-93
    • (1996) Xenobiotica , vol.26 , pp. 681-693
    • Ono, S.1    Hatanaka, T.2    Hotta, H.3    Satoh, T.4    Gonzalez, F.J.5    Tsutsui, M.6
  • 32
    • 33847515396 scopus 로고
    • Human cytochrome P450 enzymes, Cytochrome P450: Structure, Mechanism and Biochemistry
    • Guengerich FP: Human cytochrome P450 enzymes, Cytochrome P450: Structure, Mechanism and Biochemistry. Edited by Ortiz de Montellano PR. New York, Plenum Press, 1995, pp 473535
    • (1995) Edited by Ortiz De Montellano PR. New York, Plenum Press , pp. 473535
    • Guengerich, F.P.1
  • 34
    • 0028925110 scopus 로고
    • Human kidney niethoxyflurane and sevoflurane metabolism: Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
    • Kharasch ED, Hankins DC, Tliummel KE: Human kidney niethoxyflurane and sevoflurane metabolism: Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. ANESTIIESIOLOGY 1995; 82:689-99
    • (1995) ANESTIIESIOLOGY , vol.82 , pp. 689-699
    • Kharasch, E.D.1    Hankins, D.C.2    Tliummel, K.E.3
  • 36
    • 0031026584 scopus 로고    scopus 로고
    • Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators
    • O'Shea D, Kim RB, Wilkinson GR: Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators. Br J Clin Pharmacol 1997; 43:99-103
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 99-103
    • O'Shea, D.1    Kim, R.B.2    Wilkinson, G.R.3
  • 37
    • 0030802792 scopus 로고    scopus 로고
    • Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization
    • Chien JY, Tliummel KE, Slattery JT: Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization. Drug Metab Dispos 1997; 25:1165-74
    • (1997) Drug Metab Dispos , vol.25 , pp. 1165-1174
    • Chien, J.Y.1    Tliummel, K.E.2    Slattery, J.T.3
  • 38
    • 0020657226 scopus 로고
    • Enflurane, isoflurane, and methoxyflurane metabolism in rat hepatic microsomes from ethanol-treated animals
    • Van Dyke RA: Enflurane, isoflurane, and methoxyflurane metabolism in rat hepatic microsomes from ethanol-treated animals. AXESTHESIOLOCY 1983; 58:221-4
    • (1983) AXESTHESIOLOCY , vol.58 , pp. 221-224
    • Van Dyke, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.