Low activities of intestinal lactase suppress the early phase absorption of soy isoflavones in Japanese adults

Clinical Nutrition

Volumn 27, Issue 2, 2008, Pages 248-253

  Tamura, Akiko ^a,b   Shiomi, Takuya ^a   Hachiya, Sachiko ^a   Shigematsu, Norihiro ^a   Hara, Hiroshi ^b  

^a Central Research Development Laboratory Fancl Corporation   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Breath hydrogen; Equol; Isoflavones; Lactase; Lactose malabsorption

Indexed keywords

DAIDZEIN; GENISTEIN; GLUCOSIDE; ISOFLAVONE DERIVATIVE; LACTASE; LACTOSE;

ADULT; ARTICLE; BIOAVAILABILITY; CORRELATION ANALYSIS; DEGLYCOSYLATION; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FEMALE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; HYDROGEN BREATH TEST; INTESTINE ABSORPTION; INTESTINE TRANSIT TIME; JAPANESE; LACTOSE INTOLERANCE; LARGE INTESTINE; MALE; NORMAL HUMAN; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; SMALL INTESTINE; SOYBEAN MILK;

ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BREATH TESTS; FEMALE; GASTROINTESTINAL TRANSIT; GENISTEIN; GLUCOSIDES; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; ISOFLAVONES; JAPAN; LACTASE; LACTOSE INTOLERANCE; MALE; SOY MILK;

EID: 41349117163     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2007.12.001     Document Type: Article

References (29)

1. Setchell K.D., and Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J Nutr 129 (1999) S758-S767
2. Setchell K.D., Brown N.M., and Lydeking-Olsen E. The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132 (2002) 3577-3584
3. Setchell K.D., and Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 78 (2003) S593-S609
4. Horn-Ross P.L., John E.M., Canchola A.J., Stewart S.L., and Lee M.M. Phytoestrogen intake and endometrial cancer risk. J Natl Cancer 95 (2003) 1158-1164
5. Akaza H., Miyanaga N., Takashima N., et al. Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents. Jpn J Clin Oncol 34 (2004) 86-89
6. Ozasa K., Nakao M., Watanabe Y., et al. Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men. Cancer Sci 95 (2004) 65-71
7. Arai Y., Watanabe S., Kimira M., Shimoi K., Mochizuki R., and Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130 (2000) 2243-2250
8. Yamamoto S., Sobue T., Sasaki S., et al. Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in Japanese population in comparison with dietary records and blood and urine isoflavones. J Nutr 131 (2001) 2741-2747
9. Nagata C., Shimizu H., Takami R., Hayashi M., Takeda N., and Yasuda K. Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women. Osteoporos Int 13 (2002) 200-204
10. Ozasa K., Nakao M., Watanabe Y., et al. Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC study. J Epidemiol 15 (2005) S196-S202
11. Setchell K.D., Brown N.M., Zimmer-Nechemias L., et al. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 76 (2002) 447-453
12. Nemeth K., Plumb G.W., Berrin J.G., et al. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 42 (2003) 29-42
13. Rowland I., Faughnan M., Hoey L., Wahala K., Williamson G., and Cassidy A. Bioavailability of phyto-oestrogens. Br J Nutr 89 (2003) S45-S58
14. Day A.J., Canada F.J., Diaz J.C., et al. Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 468 (2000) 166-170
15. Ogata Y., and Yao T. Hypolactasia in Japanese Chron's patients. Nippon Shokakibyo Gakkai Zasshi (J Jpn Soc Gastroenterol) 89 (1992) 2655-2663 [Japanese]
16. Kondo T., Liu F., and Toda Y. Milk is a useful test meal for measurement of small bowel transit time. J Gastroenterol 29 (1994) 715-720
17. Vesa T.H., Marteau P., and Korpela R. Lactose intolerance. J Am Coll Nutr 19 (2000) S165-S175
18. Rosado J.L., and Solomons N.W. Sensitivity and specificity of the hydrogen breath-analysis test for detecting malabsorption of physiological doses of lactose. Clin Chem 29 (1983) 545-548
19. Carroccio A., Montalto G., Cavera G., and Notarbatolo A. Lactose intolerance and self-reported milk intolerance: relationship with lactose maldigestion and nutrient intake. Lactase deficiency study group. J Am Coll Nutr 17 (1998) 631-636
20. Miyanaga N., Akaza H., Takashima N., et al. Higher consumption of green tea may enhance equol production. Asian Pac J Cancer Prev 4 (2003) 297-301
21. Johnson A.O., Semenya J.G., Buchowski M.S., Enwonwu C.O., and Scrimshaw N.S. Correlation of lactose maldigestion, lactose intolerance, and milk intolerance. Am J Clin Nutr 57 (1993) 399-401
22. Suarez F.L., and Savaiano D.A. Lactose digestion and tolerance in adult and elderly Asian-Americans. Am J Clin Nutr 59 (1994) 1021-1024
23. Hosoya N., and Mutou Y. Shouka Kyusyu. 3rd ed. (Digestion absorption). [Japanese] (2003), Daiichi Shuppan, Tokyo
24. Cummings J.H., Macfarlane G.T., and Englyst H.N. Prebiotic digestion and fermentation. Am J Clin Nutr 73 (2001) S415-S420
25. Hertzler S.R., and Savaiano D.A. Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance. Am J Clin Nutr 64 (1996) 232-236
26. Kleessen B., Sykura B., Zunft H.J., and Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 65 (1997) 1397-1402
27. Steer T.E., Johnson I.T., Gee J.M., and Gibson G.R. Metabolism of the soybean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebiotics. Br J Nutr 90 (2003) 635-642
28. Morton M.S., Arisaka O., Miyake N., Morgan L.D., and Evans B.A. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J Nutr 132 (2002) 3168-3171
29. Zubik L., and Meydani M. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am J Clin Nutr 77 (2003) 1459-1465