Folic acid transport via high affinity carrier-mediated system in human retinoblastoma cells

International Journal of Pharmaceutics

Volumn 355, Issue 1-2, 2008, Pages 210-219

  Kansara, Viral ^a   Paturi, Durga ^a   Luo, Shuanghui ^a   Gaudana, Ripal ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Cellular translocation; Folate receptor (FR); Folic acid; Human retinoblastoma cell line (Y 79); Uptake mechanism

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CALMODULIN; CHLORIDE ION; COLCHICINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOLATE RECEPTOR; FOLIC ACID; METHOTREXATE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; SODIUM ION; VITAMIN;

ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG INHIBITION; DRUG TRANSPORT; ENDOCYTOSIS; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; RETINOBLASTOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE DEPENDENCE;

ANTIMETABOLITES; CELL LINE, TUMOR; CELL MEMBRANE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DATA INTERPRETATION, STATISTICAL; DRUG CARRIERS; ENERGY TRANSFER; ENZYME INHIBITORS; FOLIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MEMBRANE TRANSPORT PROTEINS; PROTEIN KINASE C; RETINAL NEOPLASMS; RETINOBLASTOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TEMPERATURE; VITAMINS;

EID: 41349108210     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.12.008     Document Type: Article

References (41)

1. Benns J.M., Maheshwari A., Furgeson D.Y., Mahato R.I., and Kim S.W. Folate-PEG-folate-graft-polyethylenimine-based gene delivery. J. Drug Target 9 (2001) 123-139
2. Birn H., Spiegelstein O., Christensen E.I., and Finnell R.H. Renal tubular reabsorption of folate mediated by folate binding protein 1. J. Am. Soc. Nephrol. 16 (2005) 608-615
3. Bisseling T.M., Steegers E.A., van den Heuvel J.J., Siero H.L., van de Water F.M., Walker A.J., Steegers-Theunissen R.P., Smits P., and Russel F.G. Placental folate transport and binding are not impaired in pregnancies complicated by fetal growth restriction. Placenta 25 (2004) 588-593
4. Bridges C.C., El-Sherbeny A., Ola M.S., Ganapathy V., and Smith S.B. Transcellular transfer of folate across the retinal pigment epithelium. Curr. Eye Res. 24 (2002) 129-138
5. Brigle K.E., Spinella M.J., Westin E.H., and Goldman I.D. Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. Biochem. Pharmacol. 47 (1994) 337-345
6. Brzezinska A., Winska P., and Balinska M. Cellular aspects of folate and antifolate membrane transport. Acta Biochim. Pol. 47 (2000) 735-749
7. Duvvuri S., Majumdar S., and Mitra A.K. Drug delivery to the retina: challenges and opportunities. Expert Opin. Biol. Ther. 3 (2003) 45-56
8. Feschenko M.S., Stevenson E., and Sweadner K.J. Interaction of protein kinase C and cAMP-dependent pathways in the phosphorylation of the Na, K-ATPase. J. Biol. Chem. 275 (2000) 34693-34700
9. Friedman D.L., Himelstein B., Shields C.L., Shields J.A., Needle M., Miller D., Bunin G.R., and Meadows A.T. Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma. J. Clin. Oncol. 18 (2000) 12-17
10. Golnik K.C., and Schaible E.R. Folate-responsive optic neuropathy. J. Neuroophthalmol. 14 (1994) 163-169
11. Horne D.W., Reed K.A., and Said H.M. Transport of 5-methyltetrahydrofolate in basolateral membrane vesicles of rat liver. Am. J. Physiol. 262 (1992) G150-G158
12. Itoh T., Ono K., Koido K.I., Li Y.H., and Yamada H. Stereoselectivity of the folate transporter in rabbit small intestine: studies with amethopterin enantiomers. Chirality 13 (2001) 164-169
13. Kansara V., Luo S., Balasubrahmanyam B., Pal D., and Mitra A.K. Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system. Int. J. Pharm. 312 (2006) 43-52
14. Kansara V., Pal D., Jain R., and Mitra A.K. Identification and functional characterization of riboflavin transporter in human-derived retinoblastoma cell line (Y-79): mechanisms of cellular uptake and translocation. J. Ocul. Pharmacol. Ther. 21 (2005) 275-287
15. Kumar C.K., Moyer M.P., Dudeja P.K., and Said H.M. A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. J. Biol. Chem. 272 (1997) 6226-6231
16. Kyritsis A.P., Tsokos M., Triche T.J., and Chader G.J. Retinoblastoma-origin from a primitive neuroectodermal cell?. Nature 307 (1984) 471-473
17. Leamon C.P., and Low P.S. Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discov. Today 6 (2001) 44-51
18. McFall R.C., Sery T.W., and Makadon M. Characterization of a new continuous cell line derived from a human retinoblastoma. Cancer Res. 37 (1977) 1003-1010
19. Miotti S., Facheris P., Tomassetti A., Bottero F., Bottini C., Ottone F., Colnaghi M.I., Bunni M.A., Priest D.G., and Canevari S. Growth of ovarian-carcinoma cell lines at physiological folate concentration: effect on folate-binding protein expression in vitro and in vivo. Int. J. Cancer 63 (1995) 395-401
20. Nabokina S.M., Ma T.Y., and Said H.M. Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells. Am. J. Physiol. Cell Physiol. 287 (2004) C142-C148
21. Prasad P.D., Ramamoorthy S., Leibach F.H., and Ganapathy V. Molecular cloning of the human placental folate transporter. Biochem. Biophys. Res. Commun. 206 (1995) 681-687
22. Ross J.F., Chaudhuri P.K., and Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 73 (1994) 2432-2443
23. Sabharanjak S., and Mayor S. Folate receptor endocytosis and trafficking. Adv. Drug Deliv. Rev. 56 (2004) 1099-1109
24. Said H.M. Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annu. Rev. Physiol. 66 (2004) 419-446
25. Seme M.T., Summerfelt P., Henry M.M., Neitz J., and Eells J.T. Formate-induced inhibition of photoreceptor function in methanol intoxication. J. Pharmacol. Exp. Ther. 289 (1999) 361-370
26. Shen F., Wu M., Ross J.F., Miller D., and Ratnam M. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry 34 (1995) 5660-5665
27. Shields C.L., Honavar S.G., Meadows A.T., Shields J.A., Demirci H., Singh A., Friedman D.L., and Naduvilath T.J. Chemoreduction plus focal therapy for retinoblastoma: factors predictive of need for treatment with external beam radiotherapy or enucleation. Am. J. Ophthal. 133 (2002) 657-664
28. Shinoda T., Takagi A., Maeda A., Kagatani S., Konno Y., and Hashida M. In vivo fate of folate-BSA in non-tumor- and tumor-bearing mice. J. Pharm. Sci. 87 (1998) 1521-1526
29. Sierra E.E., Brigle K.E., Spinella M.J., and Goldman I.D. Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells. Biochem. Pharmacol. 50 (1995) 1287-1294
30. Sirotnak F.M., and Tolner B. Carrier-mediated membrane transport of folates in mammalian cells. Annu. Rev. Nutr. 19 (1999) 91-122
31. Smith S.B., Huang W., Chancy C., and Ganapathy V. Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 257 (1999) 279-283
32. Smith S.B., Kekuda R., Gu X., Chancy C., Conway S.J., and Ganapathy V. Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina. Invest. Ophthalmol. Vis. Sci. 40 (1999) 840-848
33. Spinella M.J., Brigle K.E., Sierra E.E., and Goldman I.D. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. J. Biol. Chem. 270 (1995) 7842-7849
34. Theti D.S., and Jackman A.L. The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clin. Cancer Res. 10 (2004) 1080-1089
35. Tombran-Tink J., Li A., Johnson M.A., Johnson L.V., and Chader G.J. Neurotrophic activity of interphotoreceptor matrix on human Y79 retinoblastoma cells. J. Comp. Neurol. 317 (1992) 175-186
36. van Steenis J.H., van Maarseveen E.M., Verbaan F.J., Verrijk R., Crommelin D.J., Storm G., and Hennink W.E. Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. J. Control Rel. 87 (2003) 167-176
37. Verwei M., van den Berg H., Havenaar R., and Groten J.P. Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells. Eur. J. Nutr. 44 (2005) 242-249
38. Wang X., Shen F., Freisheim J.H., Gentry L.E., and Ratnam M. Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates. Biochem. Pharmacol. 44 (1992) 1898-1901
39. Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski Jr. V.R., and Kamen B.A. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res. 52 (1992) 3396-3401
40. Yoo H.S., and Park T.G. Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate. J. Control Rel. 100 (2004) 247-256
41. Yorek M.A., Dunlap J.A., Spector A.A., and Ginsberg B.H. Effect of ethanolamine on choline uptake and incorporation into phosphatidylcholine in human Y79 retinoblastoma cells. J. Lipid Res. 27 (1986) 1205-1213