Stereoselectivity of the folate transporter in rabbit small intestine: Studies with amethopterin enantiomers

Chirality

Volumn 13, Issue 3, 2001, Pages 164-169

  Itoh, Tomoo ^a   Ono, Kiyoko ^a   Koido, Kei Ichi ^a   Li, Yin Hua ^a   Yamada, Hideo ^a,b  

^a KITASATO UNIVERSITY   (Japan)

^b MUSASHINO UNIVERSITY   (Japan)

Author keywords

Absorption; Brush border; Membrane vesicles; Methotrexate; Transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; CARRIER PROTEIN; DEXTRO AMETHOPTERIN; FOLIC ACID; METHOTREXATE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG UPTAKE; ENANTIOMER; INTESTINE BRUSH BORDER MEMBRANE; MALE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMALL INTESTINE ABSORPTION; STEREOCHEMISTRY; TRANSPORT KINETICS;

ANIMALS; CARRIER PROTEINS; COLD; FOLIC ACID; FOLIC ACID ANTAGONISTS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINE, SMALL; JEJUNUM; MALE; METHOTREXATE; MICROVILLI; OSMOLAR CONCENTRATION; RABBITS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0035114521     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-636X(2001)13:3<164::AID-CHIR1015>3.0.CO;2-Z     Document Type: Article

References (16)

1. Jamali F, Mehvar R, Pasutto FM. Enantioselective aspects of drug action and disposition: therapeutic pitfalls. J Pharm Sci 1989;78:695-715.
2. Tucker GT, Lennard MS. Enantiomer specific pharmacokinetics. Pharm Ther 1990;45:309-329.
3. Notterman DA, Drayer DE, Metakis L, Reidenberg MM. Stereoselective renal tubular secretion of quinidine and quinine. Clin Pharmacol Ther 1986;40:511-517.
4. Hsyu P-H, Giacomini KM. Stereoselective renal clearance of pindolol in humans. J Clin Invest 1985;76:1720-1726.
5. Ott RJ, Hui AC, Wong FM, Hsyu P, Giacomini KM. Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles. Biochem Pharmacol 1991;41:142-145.
6. Ott RJ, Giacomini KM. Stereoselective interactions of organic cations with the organic cation transporter in OK cells. Pharm Res 1993;10:1169-1173.
7. Higaki K, Kadono K, Goto S, Nakano M. Stereoselective renal tubular secretion of an organic anion in the isolated perfused rat kidney. J Pharmacol Exp Ther 1994;270:329-335.
8. Itoh T, Ishida M, Onuki Y, Tsuda Y, Shimada H, Yamada H. Stereoselective renal tubular secretion of carbenicillin. Antimicrob Agents Chemother 1993;37:2327-2332.
9. Itoh T, Nakaura H, Koyano S, Tsuda Y, Yamada H. Stereoselective renal secretion of carbenicillin in rabbits: role of the organic anion transporter at the renal brush border membrane. Chirality 1998;10:349-357.
10. Tamai I, Ling H, Timbul S, Nishikido J, Tsuji A. Stereospecific absorption and degradation of cephalexin. J Pharm Pharmacol 1988:40:320-324.
11. Yoshikawa T, Muranushi N, Yoshida M, Oguma T, Hirano K, Yamada H. Transport characteristics of ceftibuten (7432-S), a new oral cephem, in rat intestinal brush-border membrane vesicles: proton-coupled and Stereoselective transport of ceftibuten. Pharm Res 1989;6:302-307.
12. Muranushi N, Horie K, Masuda K, Hirano K. Characteristics of ceftibuten uptake into Caco-2 cells. Pharm Res 1994;11:1761-1765.
13. Wenzel U, Thwaites DT, Daniel H. Stereoselective uptake of β-lactam antibiotics by the intestinal peptide transporter. Br J Pharmacol 1995;116:3021-3027.
14. Ogihara T, Tamai I, Takanaga H, Sai Y, Tsuji A. Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells. Pharm Res 1996;13:1828-1832.
15. Tsuji A, Tamai I. Review: carrier-mediated intestinal transport of drugs. Pharm Res 1996;13:963-977.
16. Smith ME, Matty AJ, Blair JA. The transport of pteroylglutamic acid across the small intestine of the rat. Biochim Biophys Acta 1970;219:37-46.