Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells

European Journal of Nutrition

Volumn 44, Issue 4, 2005, Pages 242-249

  Verwei, Miriam ^a   Van Den Berg, Henk ^a,b   Havenaar, Robert ^a   Groten, John P ^a  

^a TNO   (Netherlands)

^b The Netherlands Nutrition Centre   (Netherlands)

Author keywords

Bioavailability; Caco 2; Folate; Folate binding protein; Intestinal transport

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CAFFEINE; FOLATE BINDING PROTEIN; FOLIC ACID; MANNITOL;

ARTICLE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; MONOLAYER CULTURE; PROTEIN BINDING;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CARRIER PROTEINS; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, GEL; FOLIC ACID; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; RECEPTORS, CELL SURFACE; TETRAHYDROFOLATES; TIME FACTORS;

BOVINAE;

EID: 20444491137     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-004-0516-9     Document Type: Article

References (38)

1. Fishman SM, Christian P, West KP (2000) The role of vitamins in the prevention and control of anaemia. Public Health Nutr 3:125-150
2. Wald N, Sneddon J, Frost C, Stone R (1991) MRC Vitamin Study Group Prevention of neural tube defects. Results of the Medical Research Council Vitamin Study. Lancet 338:131-137
3. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM (1995) Folate levels and neural tube defects. J Am Med Assoc 247:1698-1702
4. Rampersaud GC, Bailey LB, Kauwell GPA (2002) Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners. J Am Diet Assoc 102:1273-1282
5. Boushey CJ, Beresford AA, Omen GS, Motulsky AG (1996) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J Am Med Assoc 274:1049-1057
6. Graham IA, O'Allaghan P (2000) The role of folic acid in the prevention of cardiovascular disease. Curr Opin Lipidol 11:577-587
7. De Bree A, Van Dusseldorp M, Brouwer IA, Van het Hof KH, Steegers-Theunissen RP (1997) Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr 51:643-660
8. Konings EJM, Roomans H, Dorant E, Goldbohm R, Saris W, van den Brandt P (2001) Folate intake of the Dutch population based newly established liquid chromatography data for foods. Am J Clin Nutr 73:765-776
9. Swiatlo N, O'Conner DL, Andrews J, Picciano MF (1990) Relative folate bioavailability from diets containing human, bovine and goat milk. J Nutr 120:172-177
10. Ghitis J (1967) The folate binding in milk. Am J Clin Nutr 20:1-4
11. Wagner C (1985) Folate Binding Proteins. Nutr Rev 43:293-299
12. Salter DN, Scott KJ, Slade H, Andrews P (1981) The preparation and properties of folate-binding protein from cow's milk. Biochem J 193:469-476
13. Holm J, Hansen SI (2001) Binding of radiolabeled folate and 5-methyltetrahydrofolate to cow's milk folate binding protein at pH 7.4 and 5.0. Relationship to concentration and polymerization equilibrium of the purified protein. Biosci Rep 21:733-743
14. Verwei M, Arkbåge K, Havenaar R, van den Berg H, Witthöft C, Schaafsma G (2003) Folic acid and 5-Methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model. J Nutr 133:2377-2383
15. Arkbåge K, Verwei M, Havenaar R, Witthöft C (2003) Addition of folate-binding protein lowers the bioaccessibility of folic acid and 5-methyltetrahydrofolate from fortified yogurt as studied in a dynamic in vitro gastrointestinal model. J Nutr 133:3678-3683
16. 4 folate as studied in a dynamic in vitro gastrointestinal model. J Nutr 134:31-37
17. Said HM, Grishan FK, Murrell JE (1985) Ontogenesis of the intestinal transport of 5-methyltetrahydrofolate in the rat. Am J Physiol 249:567-571
18. Said HM, Strum WB (1983) A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum. J Pharmacol Exp Ther 226:95-99
19. Selhub J, Powell GM, Rosenberg IH (1984) Intestinal transport of 5-methyltetrahydrofolate. Am J Physiol 246:G515-G520
20. Said HM, Grishan FK, Redha R (1987) Folate transport by human intestinal brush-border membrane vesicles. Am J Physiol 252:229-236
21. Colman N, Hettiarachchy N, Herbert V (1981) Detection of a milk factor that facilitates folate uptake by intestinal cells. Science 211:1427-1429
22. Salter D, Blakeborough P (1988) Influence of goat's-milk folate-binding protein on transport of 5-methyltetrahydrofolate in neonatal-goat small intestinal brush-border-membrane vesicles. Br J Nutr 59:497-507
23. Said HM, Horne DW, Wagner C (1986) Effect of human folate binding protein on folate intestinal transport. Archiv Biochem Biophys 251:114-120
24. Tani M, Fushiki T, Iwai K (1983) Influence of folate binding protein from bovine milk on the absorption of folate in gastrointestinal tract of rat. Biochim Biophys Acta 757:274-281
25. Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749
26. Hillgren KM, Kato A, Borchardt RT (1995) In vitro systems for studying intestinal drug absorption. Med Res Rev 15:82-109
27. Vincent ML, Russell RM, Sasak V (1985) Folic acid uptake characteristics of a human colon carcinoma cell line Caco2. A newly described cellular model for small intestinal epithelium. Human Nutrition: Clinical Nutrition 39C:355-360
28. Artusson P, Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Com 175:880-885
29. Yazdanian M, Glynn SL, Wright JL, Hawi A (1998) Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm Res 15:1490-1494
30. Yee S (1997) In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man - fact or myth. Pharm Res 14:763-766
31. Grès M-C, Julian B, Bourrié M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G (1998) Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharm Res 15:726-733
32. Rubas W, Jezyk N, Grass GM (1993) Comparison of the permeability characteristics of human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm Res 10:113-118
33. Van den Berg H, Finglas PM, Bates C (1994) FLAIR intercomparison on serum and red cell folate. Int J Vitam Nutr Res 64:288-293
34. Faassen F, Kelder J, Lenders J, Onderwater R, Vromans H (2003) Physicochemical properties and transport of steroids across Caco-2 cells. Pharm Res 20:177-186
35. Duizer E, Penninks AH, Stenhuis WH, Groten JP (1997) Comparison of permeability characteristics of the human colonic Caco-2 and rat small intestinal IEC-18 cell lines. J Contr Rel 49:39-49
36. Forssén KM, Jägerstad MI, Wigertz K, Witthöft CM (2000) Folates and dairy products: a critical update. J Am Coll Nutr 19:1005-1105
37. Shane B (1995) In: Bailey LB (ed) Folate in Health and Disease, Marcel Dekker, Inc., New York, pp 1-22
38. Cichowicz DJ, Shane B (1987) Mammalian folylpoly-γ-glutamate synthetase. 2. substrate specificity and kinetic properties. Biochem 26:513-521