Expression of folate receptor α in the mammalian retinol pigmented epithelium and retina

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 5, 1999, Pages 840-848

  Smith, Sylvia B ^a   Kekuda, Ramesh ^a   Gu, Xiaolin ^a   Chancy, Christy ^a   Conway, Simon J ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FOLIC ACID; MESSENGER RNA; VITAMIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CHOROID VASCULARIZATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MAMMAL; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA NEUROEPITHELIAL LAYER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, NORTHERN; CARRIER PROTEINS; DNA PRIMERS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; PIGMENT EPITHELIUM OF EYE; RATS; RECEPTORS, CELL SURFACE; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0033025110     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Hewitt AT, Adler R. The retinal pigment epithelium and interphotoreceptor matrix: structure and specialized functions. In: Ogden TE, Schachat AP, eds. Retina. Vol 1. St. Louis: CV Mosby; 1997: 58-71.
2. Peyman GA, Bok D. Peroxidase diffusion in the normal and laser-coagulated primate retina. Invest Ophthalmol. 1972;11:35-45.
3. Hudspeth AJ, Yee AG. The intercellular functional complexes of retinal pigment epithelia. Invest Ophthalmol. 1973;12:354-365.
4. Saari JC. Retinoids in photosensitive systems. In: Sporn MB, Roberts AB, Goodman DS, eds. The Retinoids: Biology, Chemistry, and Medicine 2nd edition. New York: Raven Press; 1994:351-386.
5. Kisliuk RL. The biochemistry of folates. In: Sirotnak FM, Ensminger WD, Burchall JJ, Montgomery JA, eds. Folate Antagonists as Therapeutic Agents: Vol 1, Biochemistry, Molecular Actions and Synthetic Design. Academic Press: New York: 1984:2-53.
6. Blakley RL, Benkovic SJ. Folates and Pterins: Chemistry and Biochemistry of Folates. Vol. 1. New York: John Wiley & Sons; 1984.
7. Golnik KC, Schaible ER. Folate-responsive optic neuropathy. J. Neuroophthalmol. 1994;14:163-169.
8. Knox DL, Chen MF, Guilarte TR, Dang CV, Burnette J. Nutritional amblyopia: folic acid, vitamin B-12, and other vitamins. Retina. 1982;2:288-293.
9. Miller NR. The optic nerve. Curr Opin Neurol. 1996;9:5-15.
10. Sadun AA, Martone JF, Muci-Mendoza R, et al. Epidemic optic neuropathy in Cuba. Arch Ophthalmol. 1994;112:691-699.
11. Bittner V, Rogers WJ, Weiner DH, Kronenberg MW, Greenberg B, McIntyre KM. Optic and peripheral neuropathy in Cuba. JAMA. 1994;271:662-664.
12. Sadun A, Rubin R. Residual psychophysical deficits following recovery from the Cuban epidemic of optic neuropathy. In: Lakshminarayan V. ed. Basic and Clinical Applications of Vision Science. Dordrecht: Kluwer: 1997:231-234.
13. 5-methyltetrahydrofolate uptake in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1997;38:1578-1587.
14. Antony AC. Folate receptors. Annu Rev Nutr. 1996;16:501-521.
15. Anderson RG, Kamen BA, Rothberg KG, Lacey SW. Potocytosis: sequestration and transport of small molecules by caveolae. Science, 1992;255:410-411.
16. Anderson RG. Caveolae: where incoming and outgoing messengers meet. Proc. Natl Acad Sci USA. 1993;90:10909-10913.
17. Schron CM, Washington C Jr, Blitzer BL. The transmembrane pH gradient drives uphill folate transport in rabbit jejunum: direct evidence for folate/hydroxyl exchange in brush border membrane vesicles. J. Clin Invest. 1985;76:2030-2033.
18. Horne DW, Reed KA, Hoefs J, Said HM. 5-Methyltetrahydrofolate transport in basolateral membrane vesicles from human liver. Am J Clin Nutr. 1993;58:80-81.
19. Prasad PD, Ramamoorthy S, Moc AJ, Smith CH, Leibach FH, Ganapathy V. Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta. 1994; 1223:71-75.
20. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V. Molecular cloning of the human placental folate transporter. Biochem Biophys Res Commun. 1995;206:681-687.
21. +-ATPase. Exp Eye Res. 1980;3:351-60.
22. + -ATPase in retinal pigment epithelium is linked to a reversal of the ankyrin-fodrin submembrane cytoskeleton. J. Cell Biol. 1991;112:863-872.
23. Kelley LK, Smith CH, King BF. Isolation and partial characterization of the basal cell membrane of human placental trophoblast Biochim Biophys Acta. 1983;734:91-98.
24. Smith SB, Duncan T, Kutty G, Kutty RK, Wiggert B. Increase in retinyl palmitate concentration in eyes and livers and the concentration of interphotoreceptor retinoid-binding protein in eyes of vitiligo mutant mice. Biochem J. 1994;300:63-68.
25. Blakely RD, Clark JA, Rudnick G, Amara SG, Vaccinia-T7 RNA polymerase expression system: evaluation for the expression cloning of plasma membrane transporters. Anal Biochem. 1991;194:302-308.
26. Ramamoorthy S, Leibach FH, Mahesh VB, et al. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J. 1994;300:893-900.
27. Cowen KH, Jolivet JA. A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates. J Biol Chem. 1984;259:10793-10800.
28. Dixon KH, Mulligan T, Chung KN, Elwood PC, Cowan KH. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells. J Biol Chem. 1992;267:24140-24147.
29. Prasad PD, Mahesh VB, Leibach FH, Ganapathy V. Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochem Biophys Acta. 1994;1222:309-314.
30. Brigle KE, Westin EH, Houghton MT, Goldman ID. Characterization of two cDNAs encoding folate binding proteins from L1210 murine leukemia cells: increased expression associated with a genomic rearrangement. J Biol Chem. 1991;266:17243-17249.
31. Weitman SD, Lark RH, Coney LR, et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res. 1992;52:3396-3401.
32. Braissant O, Wahli W. A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNA on tissue sections. Biochemica. 1998;1:10-16.
33. Ratnam M, Marquardt H, Duhring JL, Freisheim JH. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry, 1989;28:8249-8254.
34. Shen F, Wu M, Ross JF, Miller D, Ratnam M. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry. 1995;34:5660-5665.
35. Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project. JAMA. 1997;277:1775-1781.
36. Guba SC, Fink LM, Fonseca V. Hyperhomocysteinemia: an emerging and important risk factor for thromboembolic and cardiovascular disease. Am J Clin Pathol. 1996;106:709-722.
37. Lentz SR, Malinow MR, Piegors DJ, Bhopatkar-Teredesai M, Faraci FM, Heistad DD. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys. Arterioscler Thromb Vasc Biol. 1997;17:2930-2934.
38. Legnani C, Palareti G, Grauso F, et al. Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Va1 MTHFR) in patients with inherited thrombophilic coagulation defects. Arterioscler Thromb Vasc Biol. 1997;17:2924-2929.