Cytotoxic Mannich bases of 1-arylidene-2-tetralones

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 4, 2003, Pages 313-324

  Dimmock, J R ^a   Padmanilayam, M P ^a   Das, U ^a   Zello, G A ^a   Sharma, R K ^b   Shrivastav, A ^b   Selvakumar, P ^b   Pasha, M K ^b   Nienaber, K H ^c   Lee, J S ^c   Allen, T M ^d   Santos, C L ^d   Balzarini, J ^e   De Clercq, E ^e  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b SASKATCHEWAN CANCER AGENCY   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

2 tetralones; Cytotoxicity; Mannich bases; N myristoyltransferase

Indexed keywords

1 ARYLIDENE 2 TETRALONE DERIVATIVE; ALKENE DERIVATIVE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DNA; MANNICH BASE; MELPHALAN; PROTEIN N MYRISTOYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STANDARD; THYMUS; TUMOR CELL LINE;

ACYLTRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; LEUKEMIA L1210; LEUKEMIA P388; LEUKEMIA, T-CELL; MANNICH BASES; MICE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TETRALONES;

ANIMALIA; MURINAE;

EID: 12444317554     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636031000121929     Document Type: Article

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