Antiproliferative and antiinvasive effects of carboxyamido-triazole on breast cancer cell lines

Surgery

Volumn 122, Issue 2, 1997, Pages 372-379

  Lambert, Paul A ^b   Somers, Kenneth D ^b   Kohn, Elise C ^b   Perry, Roger R ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; CALCIUM CHANNEL BLOCKING AGENT; MATRIX METALLOPROTEINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0030772486     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6060(97)90029-5     Document Type: Conference Paper

References (25)

1. Liotta LA. Tumor invasion and metastases: role of the extracellular matrix. Cancer Res 1986;46:1-7.
2. Fidler IJ. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 1978;38:2651-60.
3. Kohn EC, Jacobs W, Kim YS, Alessandro WG, Stetler-Stevenson WG, Liotta LA. Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression. J Biol Chem 1994;269:21505-11.
4. Kohn EC, Liotta LA. L651582: A novel antiproliferative and antimetastatic agent. J Natl Cancer Inst 1990;82:54-60.
5. Felder CC, Ma AL, Liotta LA, Kohn EC. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther 1991;257:967-71.
6. Kohn EC, Alessandro R, Spoonster J, Wersto RP, Liotta LA. Angiogenesis: role of calcium-mediated signal transduction. Proc Natl Acad Sci (USA) 1995;92:1307-11.
7. Rodland KD, Wersto RP, Hobson S, Kohn EC. Thapsigargin-induced gene expression in non-excitable cells is dependent on calcium influx. Mol Endocrinol 1997;11:281-91.
8. Kohn EC, Felder CC, Jacobs W, Holmes KA, Day A, Freer R, et al. Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res 1994;54:935-42.
9. Kohn EC, Sandeen MA, Liotta LA. In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. Cancer Res 1992;52:3208-12.
10. Volpe DA, Cole K, Sandeen MA, Kohn EC. In vitro and in vivo myelotoxicity of CAI to human and murine hematopoietic progenitor cells. Am J Hematol 1995;50:277-82.
11. Kohn EC, Reed E, Sarosy G, Christian M, Link CJ, Cole K, et al. Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res 1996;56:569-73.
12. Kang Y, Perry RR. Modulatory effects of tamoxifen and recombinant human α-interferon on doxorubicin resistance. Cancer Res 1993;53:3040-5.
13. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semi-automated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987;47:936-42.
14. Perry RR, Greaves BR, Raspberry U, Barranco SC. Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in-vitro. Cancer Res 1992;52:4608-12.
15. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, et al. A rapid in vitro assay for quantitating the invasion potential of tumor cells. Cancer Res 1987;47:3239-45.
16. Thompson EW, Shima TB, Reich R, Graf J, Albini A, Martin GR, et al. Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens. Cancer Res 1988;48:6764-8.
17. Brown PD, Levy AT, Margulies IMK, Liotta LA, Stetler-Stevenson WG. Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res 1990;50:6184-91.
18. Bradley G, Juranka PF, Ling V. Mechanism of multidrug resistance. Biochim Biophys Acta 1998;948:87-128.
19. Coopman PJ, Bracke ME, Lissitzky JC, DeBruyne GK, van Roy FM, Foidart JM, et al. Influence of basement membrane molecules on directional migration of human breast cell lines in vitro. J Cell Sci 1991;98:395-401.
20. Siegal GP, Barsky SH, Terranova VP, Liotta LA. Stages of neoplastic transformation of human breast tissue as monitored by dissolution of basement membrane components. Invasion Metastasis 1981;1:54-6.
21. Burtin P, Chananel G, Foidart JM, Martin E. Antigens of basement membrane in the peritumoral stroma in human colon adenocarcinomas: an immunofluorescence study. Int J Cancer 1982;30:13-8.
22. Wasilenko WJ, Palad AJ, Somers KD, Blackmore PF, Kohn EC, Rhim JS, et al. Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Int J Cancer 1996;68:259-64.
23. Ura H, Bonfil RD, Reich R, Reddel R, Pfeifer A, Harris CC. Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res 1990;50:4121-30.
24. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-36.
25. Azzam HS, Arand G, Lippman ME, Thompson EW. Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. J Natl Cancer Inst 1993;85:1758-64.