Inhibition of angiogenesis in liver metastases by carboxyamidotriazole (CAI)

Angiogenesis

Volumn 2, Issue 4, 1998, Pages 373-379

  Luzzi, Keith J ^a   Varghese, Hemanth J ^a   MacDonald, Ian C ^a   Schmidt, Eric E ^a   Kohn, Elise C ^c   Morris, Vincent L ^a   Marshall, Kathryn E ^a   Chambers, Ann F ^a,b   Groom, Alan C ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON REGIONAL CANCER PROGRAM   (Canada)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Anti cancer therapeutics; Metastasis; Signal transduction

Indexed keywords

EID: 0000240266     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009259521092     Document Type: Article

References (26)

1. Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971; 285, 1182-1186.
2. Liotta LA, Kleinerman J, Seidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 1974; 34, 997-1004.
3. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1995; 1, 27-31.
4. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998; 49, 407-424.
5. Kohn EC, Liotta LA. L651582: A novel antiproliferative and antimetastasis agent. J Natl Cancer Inst 1990; 82, 54-60.
6. Felder CC, Ma AL, Liotta LA, Kohn EC. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther 1991; 257, 967-971.
7. Hupe DJ, Bolez R, Cohen CJ, et al. The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. J Biol Chem 1991; 266, 10136-10142.
8. Kohn EC, Sandeen MA, Liotta LA. In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. Cancer Res 1992; 52, 3208-3212.
9. Kohn EC, Figg WD, Sarosy GA, et al. Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations. J Clin Oncol 1997; 15, 1985-1993.
10. Christian MC, Pluda JM, Ho PTC, et al. Promising new agents under development by the Division of Cancer Treatment, Diagnosis, and Centers of the National Cancer Institute. Sem Oncol 1997; 24, 219-240.
11. Kohn EC, Felder CC, Jacobs W, et al. Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res 1994; 54, 935-942.
12. Kohn EC, Alessandro R, Spoonster J, et al. Angiogenesis: role of calcium-mediated signal transduction. Proc Natl Acad Sci USA 1995; 92, 1307-1311.
13. Chambers AF, MacDonald IC, Schmidt EE, et al. Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev 1995; 14, 279-301.
14. Koop S, Schmidt EE, MacDonald IC, et al. Independence of metastatic ability and extravasation: Metastatic ras-transformed and control fibroblasts extravasate equally well. Proc Natl Acad Sci USA 1996; 93, 11080-11084.
15. Fidler IJ. Selection of successive tumor lines for metastasis. Nature 1973; 242, 148-149.
16. Koop S, MacDonald IC, Luzzi K, et al. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res 1995; 55, 2520-2523.
17. Morris VL, MacDonald IC, Koop S, et al. Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis. Clin Exp Metastasis 1993; 11, 377-390.
18. Wylie S, MacDonald IC, Varghese HJ, et al. The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells. Clin Exp Metastasis 1999; 17, 111-117.
19. Weibel ER. Volume 1: Practical methods for biological morphometry; and Volume 2: Theoretical foundations. In: Stereological Methods. New York: Academic Press, 1979 (Vol. 1), 1980 (Vol. 2).
20. Weibel ER. Volume 1: Practical methods for biological morphometry; and Volume 2: Theoretical foundations. In: Stereological Methods. New York: Academic Press, 1979 (Vol. 1), 1980 (Vol. 2).
21. Barbareschi M, Weidner N, Gasparini G, et al. Microvessel density quantification in breast carcinomas. Assessment by light microscopy vs. a computer-aided image analysis system. Appl Immunohistochem 1995; 3, 75-84.
22. Chosay JG, Fisher MA, Farhood A, et al. Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation. Am J Physiol 1998; 274 (Gastrointest Liver Physiol 37), G776-G782.
23. Chosay JG, Fisher MA, Farhood A, et al. Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation. Am J Physiol 1998; 274 (Gastrointest Liver Physiol 37), G776-G782.
24. Booth CJ, Sundberg JP. Hemangiomas and hemangiosarcomas in inbred laboratory mice. Lab Animal Sci 1995; 45, 497-502.
25. Tanigaki Y, Saeki Y, Matsuhisa T, et al. Antiangiogenic substance(s) in a tumor cell line with low metastatic potential originating from the BALB/c mouse liver. Invasion Metastasis 1995; 15, 70-80.
26. Lenzi R, Alpini G, Liu MH, et al. Von Willebrand factor antigen is not an accurate marker of rat and guinea pig liver endothelial cells. Liver 1990; 10, 372-379.