Experimental molecular and stem cell therapies in cardiac electrophysiology

Annals of the New York Academy of Sciences

Volumn 1123, Issue , 2008, Pages 224-231

  Gepstein, Lior ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Arrhythmias; Cell therapy; Electrophysiology; Gene therapy; Heart failure; Human embryonic stem cells; Ion channels; Pacemaker; Stem cells

Indexed keywords

ADENOVIRUS VECTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC NUCLEOTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNH2; POTASSIUM CHANNEL KIR2.1; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.4; UNCLASSIFIED DRUG;

BRADYCARDIA; CELL DIFFERENTIATION; CONFERENCE PAPER; DIASTOLE; DNA MODIFICATION; EMBRYONIC STEM CELL; GENE EXPRESSION; GENETIC ENGINEERING; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HEART REPOLARIZATION; HUMAN; LONG QT SYNDROME; MESENCHYMAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; SINUS NODE; STEM CELL GENE THERAPY; STEM CELL TRANSPLANTATION; TACHYCARDIA; TRANSGENE; VIRAL GENE THERAPY;

EID: 41149107383     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1420.025     Document Type: Conference Paper

References (50)

1. ISNER, J.M. 2002. Myocardial gene therapy. Nature 415: 234-239.
2. HAJJAR, R.J. et al. 2000. Prospects for gene therapy for heart failure. Circ. Res. 86: 616-621.
3. LAFLAMME, M.A. & C.E. MURRY. 2005. Regenerating the heart. Nat. Biotechnol. 23: 845-856.
4. DIMMELER S., A.M. ZEIHER & M.D. SCHNEIDER. 2005. Unchain my heart: the scientific foundations of cardiac repair. J. Clin. Invest. 115: 572-583.
5. REINLIB, L. & L. FIELD. 2000. Cell transplantation as future therapy for cardiovascular disease? A workshop of the National Heart, Lung, and Blood Institute. Circulation 101: E182-187.
6. KUSUMOTO, F.M. & N. GOLDSCHLAGER. 1996. Cardiac pacing. N. Engl. J. Med. 334: 89-97.
7. GEPSTEIN, L. 2005. Stem cells as biological heart pacemakers. Expert Opin. Biol. Ther. 5: 1531-1537.
8. ROSEN, M.R. et al. 2004. Genes, stem cells and biological pacemakers. Cardiovasc. Res. 64: 12-23.
9. EDELBERG, J.M., W.C. AIRD & R.D. ROSENBERG. 1998. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J. Clin. Invest. 101: 337-343.
10. MIAKE, J., E. MARBAN & H.B. NUSS. 2002. Biological pacemaker created by gene transfer. Nature 419: 132-133.
11. PLOTNIKOV, A.N. et al. 2004. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation 109: 506-512.
12. QU, J., A.N. PLOTNIKOV, et al. 2003. Expression and function of a biological pacemaker in canine heart. Circulation 107: 1106-1109.
13. MIAKE, J., E. MARBAN & H.B. NUSS. 2003. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J. Clin. Invest. 111: 1529-1536.
14. KASHIWAKURA, Y. et al. 2006. Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation 114: 1682-1686.
15. POTAPOVA, I. et al. 2004. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ. Res. 94: 952-959.
16. VALIUNAS, V. et al. 2004. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J. Physiol. 555: 617-626.
17. PLOTNIKOV, A.N. et al. 2007. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation 116: 706-713.
18. KEHAT, I. et al. 2004. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22: 1282-1289.
19. THOMSON, J.A. et al. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
20. KEHAT, I. et al. 2001. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. 108: 407-414.
21. MUMMERY, C. et al. 2003. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 107: 2733-2740.
22. XU, C. et al. 2002. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ. Res. 91: 501-508.
23. KEHAT, I. et al. 2002. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ. Res. 91: 659-661.
24. SNIR, M. et al. 2003. Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 285: H2355-2363.
25. SATIN, J. et al. 2004. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J. Physiol. 559: 479-496.
26. HE, J.Q. et al. 2003. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ. Res. 93:32-39.
27. XUE, T. et al. 2005. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 111: 11-20.
28. CHO, H.C., Y. KASHIWAKURA & E. MARBAN. 2007. Creation of a biological pacemaker by cell fusion. Circ. Res. 100: 1112-1115.
29. HOPPE, U.C. et al. 1999. Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circ. Res. 84: 964-972.
30. JOHNS, D.C. et al. 1995. Adenovirus-mediated expression of a voltage-gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver). A novel strategy for modifying excitability. J. Clin. Invest. 96: 1152-1158.
31. NUSS, H.B. et al. 1996. Reversal of potassium channel deficiency in cells from failing hearts by adenoviral gene transfer: a prototype for gene therapy for disorders of cardiac excitability and contractility. Gene Ther. 3: 900-912.
32. NUSS, H.B., E. MARBAN & D.C. JOHNS. 1999 Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. J. Clin. Invest. 103: 889-896.
33. JOHNS, D.C., E. MARBAN & H.B. NUSS. 1999. Virus-mediated modification of cellular excitability. Ann. N.Y. Acad. Sci. 868: 418-422.
34. MAZHARI, R. et al. 2002. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. J. Clin. Invest. 109: 1083-1090.
35. ENNIS, I.L. et al. 2002. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility. J. Clin. Invest. 109: 393-400.
36. KIKUCHI, K. et al. 2005. Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation 111: 264-270.
37. DONAHUE, J.K. et al. 2000. Focal modification of electrical conduction in the heart by viral gene transfer. Nat. Med. 6: 1395-1398.
38. SASANO, T. et al. 2006. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat. Med. 12: 1256-1258.
39. GAUDESIUS, G. et al. 2003. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ. Res. 39: 421-428.
40. ROOK, M.B. et al. 1992. Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs. Am. J. Physiol. 263: C959-977.
41. FAST, V.G. et al. 1996. Anisotropic activation spread in heart cell monolayers assessed by high- resolution optical mapping. Role of tissue discontinuities. Circ.Res. 79: 115-127.
42. FELD, Y. et al. 2002. Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability. Circulation 105: 522-529.
43. ABRAHAM, M.R. et al. 2005. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ. Res. 97: 159-167.
44. RUBART, M. et al. 2003. Physiological coupling of donor and host cardiomyocytes after cellular transplantation. Circ. Res. 92: 1217-1224.
45. RUBART, M. et al. 2004. Spontaneous and evoked intracellular calcium transients in donor-derived myocytes following intracardiac myoblast transplantation. J. Clin. Invest. 114: 775-783.
46. HALBACH, M. et al. 2007. Electrophysiological maturation and integration of murine fetal cardiomyocytes after transplantation. Circ. Res. 101: 484-492.
47. HALBACH, M. et al. 2006. Ventricular slices of adult mouse hearts - a new multicellular in vitro model for electrophysiological studies. Cell Physiol. Biochem. 18: 1-8.
48. SMITS, P.C. et al. 2003. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J. Am. Coll. Cardiol. 42: 2063-2069.
49. ZHANG, Y.M. et al. 2002. Stem cell-derived cardiomyocytes demonstrate arrhythmic potential. Circulation 106: 1294-1299.
50. CASPI, O. et al. 2007. Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J. Am. Coll. Cardiol. 50: 1884-1893.