Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sites

Cell and Tissue Research

Volumn 332, Issue 1, 2008, Pages 81-88

  Singh, Ashok K ^a,c   Patel, Jilpa ^c   Litbarg, Natalia O ^d   Gudehithlu, Krishnamurthy P ^a   Sethupathi, Perianna ^c   Arruda, Jose A L ^a,b   Dunea, George ^a,c  

^a Department of Ambulatory and Community Health   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c HEKTOEN INSTITUTE OF MEDICINE   (United States)

^d LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Nanog; Oct 4; Omentum; Rat (Sprague Dawley); Stem cells; WT 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR6; DEXTRAN DERIVATIVE; OCTAMER TRANSCRIPTION FACTOR 4; POLYDEXTRAN; STAGE SPECIFIC EMBRYO ANTIGEN 1; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; VASCULOTROPIN; WT1 PROTEIN;

ADULT STEM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; EMBRYO CELL; ENGRAFTMENT; NONHUMAN; OMENTUM; ORGAN INJURY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SPRAGUE DAWLEY RAT; STROMA CELL; TISSUE INJURY; TISSUE REGENERATION; TISSUE REPAIR;

ADULT STEM CELLS; ANIMALS; ANTIGENS, CD15; ANTIGENS, DIFFERENTIATION; CELL CULTURE TECHNIQUES; CELL MOVEMENT; CELL SEPARATION; CELLS, CULTURED; CHEMOKINE CXCL12; DEXTRANS; GRANULATION TISSUE; INJECTIONS, INTRAPERITONEAL; KIDNEY; OMENTUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; REPERFUSION INJURY; STEM CELL TRANSPLANTATION; STROMAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WT1 PROTEINS;

RATTUS;

EID: 41049096751     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-007-0560-x     Document Type: Article

References (42)

1. Andrews PW, Matin MM, Bahrami AR, Damjanov I, Gokhale P, Draper JS (2005) Embryonic stem (ES) cells and embryonal carcinoma (EC) cells. Opposite sides of the same coin. Biochem Soc Trans 33:1526-1530
2. Cannaday JE (1948) Some uses of undetached omentum in surgery. Am J Surg 76:502-505
3. Chambers I, Smith A (2004) Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23:7150-7160
4. Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 13:643-655
5. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, Deans RJ, Keating A, Prockop DJ, Horwitz EM (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315-317
6. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic β-cells are formed by self-duplication rather then stem-cell differentiation. Nature 429:41-46
7. Fatima B, Pinho M, Hurtado SP, El-Cheikh MC, Borojevic R (2005) Hematopoietic progenitors in the adult mouse omentum: permanent production of B lymphocytes and monocytes. Cell Tissue Res 319:91-102
8. Goldsmith HS (1994) Brain and spinal cord revascularization by omental transposition. Neurol Res 16:159-162
9. Goldsmith HS (1997) Omental transposition to the brain for Alzheimer's disease. Ann N Y Acad Sci 826:323-336
10. Goldsmith HS (2004) The evolution of omentum transposition: from lymphedema to spinal cord, stroke and Alzheimer's disease. Neurol Res 26:586-593
11. Gerrard L, Zhao D, Clark AJ, Cui W (2005) Stably transfected human embryonic stem cell clones express OCT-4 specific green fluorescent protein and maintain self-renewal and pluripotency. Stem Cells 23:124-133
12. Grove JE, Bruscia E, Krause DS (2004) Plasticity of bone marrow-derived stem cells. Stem Cells 22:487-500
13. Gudehithlu KP, Ahmed N, Yu H, Litbarg NO, Garber SL, Arruda JAL, Dunea G, Singh AK (2005) Antagonism of VEGF results in microvessel attrition and disorganization of wound tissue. J Lab Clin Med 145:194-203
14. Hatano S-Y, Tada M, Kimura H, Shinpei Y, Kono T, Nakano T, Suemori H, Nakatsuji N, Tada T (2005) Pluripotency competence of cells associated with Nanog activity. Mech Dev 122:67-79
15. Hatch HM, Zheng D, Jorgensen ML, Petersen BE (2002) SDF-1α/CXCR-4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured livers in rats. Cloning Stem Cells 4:339-351
16. Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P (2005) Hematology: basic principals and practice, 4th edn. Churchill-Livingston, Philadelphia
17. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzales XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg S, Low WC, Largaespada DA, Verfaillie CM (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-49
18. Kayali AG, Gunst KV, Campbell IL, Stotland A, Kritzik M, Guoxun L, Flodstrom-Tullberg M, Zhang Y-Q, Sarvetnick N (2003) The stromal cell-derived factor-1α (SDF-1α)/CXCR-4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol 163:859-869
19. Kerkis I, Kerkis A, Dozortsev D, Stukart-Parsons GC, Massironi SMG, Periera LV, Caplan AI, Cerruti HF (2006) Isolation and characterization of a population of immature dental pulp stem cells expressing Oct-4 and other embryonic stem cell markers. Cell Tissue Organs 184:105-116
20. Kreisberg JL, Hoover RL, Karnovsky MJ (1978) Isolation and characterization of rat glomerular epithelial cells in vitro. Kidney Int 14:21-30
21. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R (1993) WT-1 is required for early kidney development. Cell 74:679-691
22. Kuwana M, OkazakiY, Kodama H, Izumi K, Yasuoka H, Ogawa Y, Kawakami Y, Ikeda Y (2003) Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 74:833-845
23. Lee RH, Seo MJ, Reger RL, Spees JL, Pulin AA, Olson SD, Prockop DJ (2006) Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/SCID mice. Proc Natl Acad Sci USA 103:17438-17443
24. Liebermann-Meffert D (2000) The greater omentum: anatomy, embryology, and surgical applications. Surg Clin North Am 80: 275-293
25. Litbarg NO, Gudehithlu KP, Sethupathi P, Arruda JAL, Dunea G, Singh AK (2007) Activated omentum becomes rich in factors that promote healing and tissue regeneration. Cell Tissue Res 328:487-497
26. Lu F-Z, Fujino M, Kitazawa Y, Uyama T, Hara Y, Funeshima N, Jiang J-Y, Umezawa A, Li X-K (2005) Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood. J Lab Clin Med 146:271-278
27. Oliver JA, Maarouf O, Cheema FH, Martens TP, Al-Awqati Q (2004) The renal papilla is a niche for adult kidney stem cells. J Clin Invest 114:795-804
28. Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y (2001) Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104:233-245
29. Park KM, Chen M, Bonventre JV (2001) Prevention of kidney/reperfusion- induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 276:11870-11876
30. Peled A, Petit I, Kollet O, Magid M, Popomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, Lidor O, Alon R, Zipori D, Lapidot T (1999) Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283:845-848
31. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D (1990) The candidate Wilms' tumor gene is involved in genitourinary development. Nature 346:194-197
32. Ruhne M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler JG, Klapper W, Ulrichs K, Hutchinson JA, Soria B, Parwaresch RM, Heeckt P, Kremer B, Fandrich F (2005) Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 128:1774-1786
33. Sam R, Wanna L, Gudehithlu KP, Garber S, Dunea G, Arruda JAL, Singh AK (2006) Glomerular epithelial cells transform to myofibroblasts: early but not late removal of TGF-β reverses transformation. Transl Res 148:142-148
34. Singh AK, Gudehithlu KP, Pegoraro AA, Singh GK, Basheerudin K, Robey RB, Arruda JAL, Dunea G (2004) Vascular factors in glucose treated mesangial cells and diabetic glomeruli. Changes in vascular factors impair endothelial cell growth and matrix. Lab Invest 84:597-606
35. Singh AK, Gudehithlu KP, Litbarg, N, Sethupathi P, Arruda JAL, Dunea G (2007a) Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochem Biophys Res Commun 355:258-262
36. Singh AK, Gudehithlu KP, Patri S, Litbarg N, Sethupathi P, Arruda JAL, Dunea G (2007b) Impaired integration of endothelial progenitor cells in capillaries of diabetic wounds is reversible with VEGF infusion. Transl Res 149:282-291
37. Solter D, Knowles BB (1978) Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci USA 75:5565-5569
38. Sudo K, Kanno M, Miharada Ogawa S, Hiroyama T, Saijo K, Nakamura Y (2007) Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like populations. Stem Cells 25:1610-1617
39. Taylor G, Lehrer MS, Jensen PJ, Sun TT, Lavker RM (2000) Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 102:451-461
40. Togel F, HuZ, Weiss K, Isaac J, Lange C, Westenfelder C (2005) Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Renal Physiol 289:F31-F42
41. Vernik J, Singh AK (2007) Omentum: power to heal and regenerate. Int J Artif Organs 30:95-99
42. Zhao Y, Huang Z, Lazzarini P, Wang Y, Di A, Chen M (2007) A unique human blood-derived cell population displays high potential for producing insulin. Biochem Biophys Res Commun 360:205-211