Antagonism of vascular endothelial growth factor results in microvessel attrition and disorganization of wound tissue

Journal of Laboratory and Clinical Medicine

Volumn 145, Issue 4, 2005, Pages 194-203

  Gudehithlu, Krishnamurthy P ^b   Ahmed, Naila ^b   Wu, Henry ^b   Litbarg, Natalia O ^b   Garber, Sandra L ^b   Arruda, Jose A L ^b   Dunea, George ^b   Singh, Ashok K ^a  

^a Hektoen Institute for Medical Research   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; RECEPTOR BLOCKING AGENT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENCAPSULATION; EXTRACELLULAR MATRIX; FOREIGN BODY GRANULOMA; HISTOLOGY; IMPLANTATION; INTERSTITIAL FLUID; MICROVASCULATURE; MODEL; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SENSITIVITY ANALYSIS; SUBCUTANEOUS TISSUE; TUBE; WOUND; WOUND HEALING;

ANIMALS; EXTRACELLULAR MATRIX; GRANULOMA, FOREIGN-BODY; MALE; MICROCIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 18844402882     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lab.2005.02.007     Document Type: Article

References (25)

1. P. Carmeliet, V. Ferreira, G. Brier Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth factor allele Nature 380 1996 435 439
2. N. Ferrara, M.K. Carver, D. Chen Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Nature 380 1996 439 442
3. V. Eremina, M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases J Clin Invest 111 2003 707 716
4. T.R. Howdieshell, C. Riegner, V. Gupta, D. Callaway, K. Grembowicz, M.D. Sathyanarayana Normoxic wound fluid contains high levels of vascular endothelial growth factor Ann Surg 228 1998 707 715
5. H. Kampfer, J. Pfeilschifter, S. Frank Expressional regulation of angiopoietin-1 and -2 and the Tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing a comparative study of normal and impaired repair Lab Invest 81 2001 361 373
6. T. Asahara, D. Chen, T. Takahashi, K. Fujikawa, M. Kearney, M. Magner Tie-2 receptor ligands angiopoietin-1 and angiopoietin-2 modulate VEGF induced postnatal neovascularization Circ Res 83 1998 233 240
7. M.L. Springer, A.S. Chen, P.E. Kraft, M. Bednarski, H.M. Blau VEGF gene delivery to muscle potential role for vasculogenesis in adults Mol Cell 2 1998 549 558
8. J. Hasan, G.C. Kayson VEGF antagonists Expert Opin Biol Ther 1 2001 703 718
9. J. Folkman Models of anti-cancer therapy. Angiogenesis inhibitors: a new class of drugs Cancer Biol Ther 2 Suppl 1 2003 S127 S133
10. P.J. McConahey, F.J. Dixon A method of trace iodination of proteins for in vivo studies Int Arch Appl Immunol 29 1996 185 189
11. A.S. Teixeira, S.P. Andrade Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine Life Sci 64 1999 655 662
12. Y. Li, K. Metori, K. Koike, F. Kita, Q.M. Che, T. Sato Granuloma maturation in the rat is advanced by the oral administration of Eucommia ulmoides OLIVER leaf Biol Pharm Bull 23 2000 60 65
13. M.C. Rodriguez, M.P. Saiz, T. Carbonell, M.T. Mitjavila Local and systemic responses to iron dextran injected in a granuloma pouch in the rat J Lab Clin Med 134 1999 42 48
14. E. Bailey, M.J. Bottomley, S. Westwell, J.H. Pringle, P.N. Fumess, J. Feehally Vascular endothelial growth mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by non-isotopic in-situ hybridization J Clin Pathol 52 1999 735 738
15. A.K. Singh, K.P. Gudehithlu, A.A. Pegoraro, G.K. Singh, K. Basheeruddin, R.B. Robey Vascular factors altered in glucose-treated mesangial cells and diabetic glomeruli. Changes in vascular factors impair endothelial cell growth and matrix Lab Invest 84 2004 597 606
16. K. Shulman, S. Rosen, K. Tognazzi, E.J. Manseau, L.F. Brown Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases J Am Soc Nephrol 7 1996 661 666
17. D.-H. Kang, A.H. Joly, S.-W. Oh, C. Hugo, D. Kerjaschi, K.L. Gordon Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1 J Am Soc Nephrol 12 2001 1434 1437
18. Y. Wada, T. Morioka, Y. Oyanagi-Tanaka, J. Yao, Y. Suzuki, F. Gejyo Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis Kidney Int 61 2002 432 443
19. A. Rivard, M. Silver, D. Chen, M. Kearney, M. Magner, B. Annex Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF Am J Pathol 154 1999 355 363
20. P. Schratzberger, D.H. Walter, K. Rittig, F.H. Bahlmann, R. Pola, C. Curry Reversal of experimental diabetic neuropathy by VEGF gene transfer J Clin Invest 107 2001 1083 1092
21. J.G. Klekamp, K. Jarzecka, E.A. Perkett Exposure to hyperoxia decreases the expression of vascular endothelial growth factor and its receptors in adult rat lungs Am J Pathol 154 1999 823 831
22. D.-K. Kang, J. Hughes, M. Mazzali, G.F. Schreiner, R.J. Johnson Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function J Am Soc Nephrol 12 2001 1448 1457
23. L. Benjamin, E. Keshet Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal Proc Natl Acad Sci U S A 94 1997 8761 8766
24. L. Benjamin, D. Golijanin, A. Itin, D. Pode, E. Keshet Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal J Clin Invest 103 1999 159 165
25. S.E. Maynard, J.-Y. Min, J. Merchan, K.H. Lim, J. Li, S. Mondal Excess placental soluble fms-like tyrosine kinase 1 (sFlt 1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J Clin Invest 111 2003 649 658